Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: The Role of the RalA-Exocyst Pathway in the Control of Glucose Transport
Discussion Leaders: Lois Weisman (University of Michigan, USA) and Zara Weinberg (University of Michigan, USA)
3:45 pm - 4:15 pm
Alan Saltiel (University of California, San Diego, USA)
"The Role of the RalA-Exocyst Pathway in the Control of Glucose Transport"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sorting to the Lysosome: Endocytosis and Autophagy
Discussion Leaders: David Katzmann (Mayo Clinic, USA) and Diana Valverde (Yale Graduate School of Arts and Sciences, USA)
7:30 pm - 7:45 pm
Devika Andhare (Indian Institute of Science Education and Research, India)
"Numb: A Membrane-Active, Clathrin Adaptor"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Giovanni Giangreco (University of Milan, Italy)
"Epsin3 Induces a Partial EMT State in Breast Cancer Through the Regulation of E-Cadherin Endocytosis"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Kem Sochacki (National Heart, Lung, and Blood Institute, NIH, USA)
"Assembling a Growing Clathrin Coated Pit from Super-Resolution Correlative Light and Electron Microscopy"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Reini van der Welle (University Medical Center Utrecht, The Netherlands)
"Complementary Mutations in the Multitasking HOPS Complex Component Vps41 Cause a Neurodegenerative Phenotype"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Amy Clippinger (Washington University in St. Louis, USA)
"ESCRT-III Subunit IST1 Promotes Remodeling Events at the Recycling Endosome and Trans-Golgi Network"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Anne Janssen (Utrecht University, The Netherlands)
"Studying Aggrephagy Using Chemically-Induced Protein Aggregates"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Escape from the Endo-Lysosomal System: Retrograde Trafficking and Recycling / Mentorship Component: Building Your Career
Discussion Leaders: Christopher Burd (Yale School of Medicine, USA) and Kate Tubbesing (Albany Medical College, USA)
9:00 am - 9:15 am
Natalya Leneva (Cambridge Institute for Medical Research, University of Cambridge, United Kingdom)
"The Architecture of the Membrane Assembled Retromer Coat"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Andrea Toth (Aarhus University, Denmark)
"The Endo-Lysosomal System of Brain Endothelial Cells In Vitro "
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Shanna Bowman (Children's Hospital of Philadelphia / University of Pennsylvania, USA)
"Investigation of AP-3 and BLOC-1 Mediated Sorting of VAMP7 and Syntaxin-13 SNARE Complexes into Endosomal Tubule Transport Carriers Toward Melanosomes"
9:55 am - 10:00 am
Discussion
10:00 am - 11:00 am
Panel Discussion
Building Your Career
Christopher Burd (Yale School of Medicine, USA)
David Katzmann (Mayo Clinic, USA)
Alan Saltiel (University of California, San Diego, USA)
Lois Weisman (University of Michigan, USA)
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
The Lysosome: Signaling and Human Disease
Discussion Leaders: Mengxiao Ma (Yale University, USA) and Christina Mikulka (Washington University School of Medicine, USA)
1:30 pm - 1:45 pm
Yilun Deng (University of Texas Health Science Center at San Antonio, USA)
"The TMEM127 Human Tumor Suppressor Is a Component of the mTORC1 Lysosomal Nutrient Sensing Complex"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Fernando Maeda (University of Maryland, USA)
"Plasma Membrane Wounding and Repair Triggered by BCR-Antigen Interaction Promotes B Cell Activation"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Charilaos Filippakis (Brigham & Women's Hospital / Harvard Medical School, USA)
"Targeting Tsc2-Deficient Cells by Simultaneously Disrupting Parallel Nutrient Uptake Pathways"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
