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Lysosomes and Endocytosis (GRS)

Gordon Research Seminar

Physiology, Functions and Interactions of the Endo-Lysosomal System in Health and Disease

June 18 - 19, 2022

Chairs Roni Levin Konigsberg and Nadia Füllbrunn

Proctor Academy

204 Main Street

Andover, New Hampshire, United States

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Lysosomes and Endocytosis aims to serve as an inclusive platform to foster networking and collaboration between researchers. The main goal of the GRS is to enable trainees (e.g., graduate students and postdocs) to present their work, to discuss current trends, and to exchange ideas prior to the beginning of the GRC.

The meeting will focus on the life cycle and physiology of lysosomes and their diverse functions in cellular processes. Additionally, the main topics will include the interactions of lysosomes with other organelles, the association of lysosomes with diverse diseases and, the role of lysosomes and endocytosis in cell metabolism.

The GRS will also include a mentoring session, in which our mentors (faculty invitees) will discuss topics including job applications and beginning an academic career as principal investigators. Of note, this discussion will include critical topics such as diversity and inclusion in academia, and alternative career options for trainees in the life sciences.

Related Meeting

This GRS will be held in conjunction with the "Lysosomes and Endocytosis" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Keynote Session: Organelle Dynamics and Remodeling Discussion Leader: Destiny Schultz (Mayo Clinic, United States)
3:45 pm - 3:50 pm	Introduction by Discussion Leader
3:50 pm - 4:05 pm	Suzanne Pfeffer (Stanford University School of Medicine, United States) "Spatial Control of Rab GTPase Phosphorylation by Pathogenic LRRK2 Kinase"
4:05 pm - 4:10 pm	Discussion
4:10 pm - 4:25 pm	Mike Henne (University of Texas Southwestern Medical Center, United States) "Liquid-Crystalline Lipid Phase Transitions in Lipid Droplets Selectively Remodel the LD Proteome"
4:25 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Endocytosis and Inter-Organelle Communication and Dynamics Discussion Leader: Junyi Zou (University of Chicago, United States)
7:30 pm - 7:45 pm	Jonathan Striepen (University of Colorado Boulder, United States) "Coronin 1C Restricts Endosomal Branched Actin to Organize ER Contact and Endosome Fission"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	Deborah Salvi Mesa (European Institute of Oncology (IEO), Italy) "Interorganelle Contact Sites Regulate EGFR Endocytosis"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	Zinia D'Souza (University of Arkansas for Medical Sciences, United States) "EnSNAREing the Golgi Tethering and Fusion Machinery"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	Mariana Jimenez (Vanderbilt University, United States) "P4-ATPases Require Retromer for Their Localization"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	Ewan MacDonald (Institut Curie/NCBS, France) "EGF-Induced Desialylation Controls Glycolipid-Lectin Dependent Endocytosis"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	Rebecca Cabral-Dias (Ryerson University, Canada) "Fyn is Recruited to Clathrin Coated Pits and Regulates SHIP2 Recrutiment and Akt Signaling"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	The Life-Cycle of Lysosomes: Functions in Health and Disease Discussion Leader: Claudio Bussi (The Francis Crick Institute, United Kingdom)
9:00 am - 9:15 am	Pallavi Mathur (Institut Curie, France) "Transcription Factor EB Regulates Phosphatidylinositol-3-Phosphate Levels on Endomembranes and Alters Lysosome Positioning in the Bladder Cancer Model"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	Meenakshi Bhardwaj (De Montfort University, United Kingdom) "Cytoplasmic sphingolipids reactivate Lysosomes in Neurodegenerative diseases"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	Jie Li (New York University School of Medicine, United States) "SKP1 Phosphorylation Regulates the Switch Between Autophagy and Unconventional Secretion"
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	Julia Heiby (Leibniz Institute on Aging – Fritz Lipmann Institute (FLI), Germany) "Mapping the Composition of Lysosomes in Different Cell Types of the Brain"
10:15 am - 10:20 am	Discussion
10:20 am - 10:35 am	Jonathan Stahl-Meyer (The Danish Cancer Society, Denmark) "Non-lethal lysosomal leakage in chromosome segregation"
10:35 am - 10:40 am	Discussion
10:40 am - 10:55 am	Katherine Surridge (University of Bristol, United Kingdom) "Coupling of Nutrient Signalling and Lysosome Transport by the FLCN-FNIP Complex"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Technologies to Study the Endo-Lysosomal System Discussion Leader: Eugenia Almacellas (Molecular Cell Biology of Autophagy Laboratory, The Francis Crick Institute, United Kingdom)
1:30 pm - 1:45 pm	Anand Saminathan (Harvard Medical School, Boston Children Hospital, United States) "Endosome Fission Triggers Transient Endosomal Membrane Damage-Repair"
1:45 pm - 1:50 pm	Discussion
1:50 pm - 2:05 pm	Frances Hundley (Harvard Medical School, United States) "Spatial Snapshots of a Amyloid Precursor Protein Intramembrane Processing Via Early Endosome Proteomics"
2:05 pm - 2:10 pm	Discussion
2:10 pm - 2:25 pm	G. Aditya Kumar (University of Michigan, United States) "Clathrin-Coated Pits Represent Membrane Domains With a Distinct Lipid Order"
2:25 pm - 2:30 pm	Discussion
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

Contributors

Funding for this conference was made possible (in part) by 1R13CA271460-01 from the National Cancer Institute, the National Center for Advancing Translational Sciences, the National Institute on Aging, the National Institute on Allergy and Infectious Diseases and the Eunice Kennedy Shriver National Institute of Child Health & Human Development National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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Conference History Lysosomes and Endocytosis

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