SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
5:30 pm | Welcome Reception on the Cloisters Lawn |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Welcome / Introductory Comments by GRC Site Staff |
7:45 pm - 9:30 pm | DRUG TARGETS AND MECHANISMS OF DRUG RESISTANCE |
| Discussion Leader: Tim Wells (Medicines for Malaria Venture, Geneva) |
7:45 pm - 8:10 pm | David Fidock (Albert Einstein College of Medicine, New York) "Recent insights into mechanisms of P. falciparum resistance to anti-malarial drugs" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Yongyuth Yuthavong (National Centre for Biotechnology, Bangkok) "Plasmodium DHFR as a paradigm for target-based drug development" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Margaret Philips (Texas Southwestern, Dallas) "Targeting malarial dihydroorotate dehydrogenase" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | MOLECULAR MECHANISMS OF HEPATOCYTE INVASION BY MALARIA PARASITES |
| Discussion Leader: Robert Menard (Institut Pasteur, Paris) |
9:00 am - 9:30 am | Volker Heussler (Bernard Nocht Institute for Tropical Medicine, Hamburg) "Live and let die: Manipulation of host hepatocytes by Plasmodium parasites" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Stefan Kappe (Seattle Biomedical Research Institute, Seattle) "Aspects of hepatocyte infection and intra-hepatocytic development" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break / Group Photo |
11:00 am - 11:30 am | Maria Mota ((Instituto de Medicina Molecular, Lisbon) "The impact of blood stage infection on Plasmodium development inside hepatocytes" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Robert Menard (Institut Pasteur, Paris) "Revisiting the pre-erythrocytic phase of rodent malaria" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | TRANSMISSION OF PARASITES FROM HOST TO VECTOR |
| Discussion Leader: Robert Sinden (Imperial College, London) |
7:30 pm - 7:55 pm | Elena Levashina (Institute of Molecular Biology, Strasbourg) "Mosquito immune responses to malaria parasites: complement-like cascade and beyond" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Ken Vernick (Institut Pasteur, Paris) "Genetic and functional dissection of natural mosquito defenses against malaria parasite infection" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Oliver Billker (The Wellcome Trust Sanger Institute, Cambridge) "Signal transduction pathways regulating parasite development in the mosquito" |
9:05 pm - 9:20 pm | Rita Tewari (University of Nottingham, Nottingham) "Signal transduction pathways regulating parasite development in the mosquito" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | MOLECULAR MECHANISMS OF ERYTHROCYTE INVASION BY MALARIA PARASITES |
| Discussion Leader: Tony Holder (National Institute of Medical Research, Mill Hill) |
9:00 am - 9:30 am | Michael Blackman (National Institute of Medical Research, Mill Hill) "Proteolytic processing of merozoite surface proteins: insights into function and regulation" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Jake Baum (Walter and Eliza Hall Institute of Medical Research, Melbourne) "Molecular mechanics of the invasion machinery during merozoite entry: old dogmas and new insights" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Pushkar Sharma (National Institute of Immunology, New Delhi) "Dissection of signaling pathways in blood stages of malaria parasite" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | David Sibley (Washington University, St. Louis) "Functional analyses of calcium-dependent kinases in Toxoplasma" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | MOLECULAR BASIS OF PATHOGENESIS |
| Discussion Leader: Patrick Duffy (Seattle Biomedical Research Institute, Seattle) |
7:30 pm - 7:50 pm | Pierre Buffet (Hôpital Pitié Salpêtrière, Paris) "New tools to study the retention of P. falciparum-infected erythrocytes in the human spleen" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Tony Holder (National Institute of Malaria Research, Mill Hill) "Merozoite proteins and malarial anemia" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Brendan Crabb (Burnet Institute, Melbourne) "A translocon of exported proteins in Plasmodium parasites" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Ali Salanti (University of Copenhagen, Copenhagen) "Towards a vaccine against placental malaria - Induction of VAR2CSA specific anti-adhesive antibodies" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | IMMUNITY TO MALARIA |
| Discussion Leader: Carole Long (National Institutes of Health, USA) |
9:00 am - 9:30 am | Fidel Zavala (John Hopkins University, Baltimore) "Functional properties of memory CD8+ T cells against malaria liver stages" |
9:30 am - 9:45 am | Discussion |
9:45 am -10:15 am | Eleanor Riley (London School of Tropical Medicine and Hygiene, London) "Regulating cellular immunity to malaria" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Dominic Kwiatkowski (Sanger Institute, Cambridge) "Immunity and genome variation" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Kevin Marsh (KEMRI - Wellcome Trust Programme, Kilifi) "Field studies of naturally acquired immunity to malaria: Helpful or confusing?" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | NOVEL APPROACHES TO MALARIA VACCINE DEVELOPMENT |
| Discussion Leader: Ashley Birkett (PATH Malaria Vaccine Initiative, Bethesda) |
7:30 pm - 7:50 pm | Johan Vekemans (GlaxoSmithKline Biologicals, Rixensart) "RTS,S/AS: Status and plans" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Adrian Hill (Jenner Institute, Oxford) "Towards more effective malaria vaccines" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Richard Pleass (University of Nottingham, Nottingham) "Engineering antibodies for novel vaccination approaches" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Ashley Birkett (PATH Malaria Vaccine Initiative, Bethesda) "The PATH Malaria Vaccine Initiative: Current portfolio status and future vaccine development strategies" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | PLASMODIUM GENOMES AND POST-GENOME BIOLOGY |
| Discussion Leader: Chris Newbold (Institute of Molecular Medicine, Oxford) |
9:00 am - 9:30 am | Sarah Volkman (Harvard School of Public Health, Boston) "Genome-wide analysis of genetic diversity in Plasmodium falciparum" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Jane Carlton (New York University, New York) "Towards a genetic diversity map of Plasmodium vivax" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Christian Doerig (Inserm U609, University of Glasgow, Scotland and Ecole Polytechnique Federale de Lausanne, Switzerland) "P. falciparum kinomics" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Amit Sharma (International Centre for Genetic Engineering & Biotechnology, New Delhi) "Structural biology of malaria parasite proteins: Insights and implications" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm | Reception on the Cloisters Lawn |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | CONTROL OF GENE EXPRESSION |
| Discussion Leader: Pradip Rathod (University of Washington, Seattle) |
7:30 pm - 7:55 pm | Artur Scherf (Institut Pasteur, Paris) "Genes expressed at the nuclear periphery, what is so special about it?" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Kirk Deitsch (Weill Medical College of Cornell University, New York) "Active transcription by RNA polymerase II and the maintenance of epigenetic memory in P. falciparum" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Andy Waters (University of Glasgow, Glasgow) "Another role for SIR2 in the biology of Plasmodium" |
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am | Departure |