SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Drugs and Drug Resistance |
| Discussion Leader: Xin-zhuan Su (NIH) |
7:40 pm - 8:10 pm | Tim Anderson (Texas Biomedical Research Institute
"Malaria genomics in a public health crisis"
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8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Elizabeth Winzeler (University of California)
"Using genomics to discover chemically-validated targets for an eradication agenda"
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8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Grazia Camarda (Istituto Superiore Di Sanita)
"Development of a Plasmodium falciparum in vitro screening assay for gametocytocidal compounds"
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9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Pradip Rathod (University Of Washington)
"Parasite mutagenesis pathways that can challenge malaria eradication strategies"
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9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Virulence Mechanisms |
9:00 am - 9:10 am | Discussion Leader: Alexandra Rowe (University of Edinburgh) |
9:10 am - 9:40 am | Kevin Kain (University of Toronto)
"Endothelial-pathogen interactions at the interface of severe malaria"
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9:40 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Hernando del Portillo (CRESIB)
"Role of reticulocyte-derived exosomes in Plasmodium vivax malaria"
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10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Group Photo / Coffee Break |
10:50 am - 11:05 am | Sue Pierce (NIH, NIAID)
"Tipping the scale in severe malaria: the interplay of host genes and the environment in mouse models"
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11:05 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Lars Hviid (University of Copenhagen)
"The role of non-specific IgM binding in PfEMP1-mediating resetting"
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11:25 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Michelle Wykes (Queensland Institute of Medical Research)
"Restoration of protection against malaria in mice without PD-1"
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11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Sarah Hochman (Albert Einstein College Of Medicine)
"Fatal Pediatric Cerebral Malaria Pathology Reveals Intravascular Inflammation and Coagulation that is Exacerbated by HIV-1 Co-infection"
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12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Ioannis Vakonakis (University Of Oxford)
"A molecular model of knob and PfEMP1 localization on the erythrocyte surface"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Mosquito Stages |
5:30 pm - 5:40 pm | Discussion Leader: Marcelo Jacobs-Lorena (John Hopkins Bloomberg School of Health) |
5:40 pm - 6:10 pm | Carolina Barillas-Mury (NIAID)
"Malaria Transmission: a tale of mosquito immune activation and Plasmodium immune evasion"
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6:10 pm - 6:20 pm | Discussion |
6:20 pm - 6:40 pm | George Dimopoulos (Johns Hopkins Bloomberg School of Public Health)
"Exploiting transmission bottlenecks in the mosquito vector"
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6:40 pm - 6:50 pm | Discussion |
6:50 pm - 7:20 pm | Oliver Billker (Wellcome Trust Sanger Institute)
"Regulation of sexual development through signal transduction and transcription" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Host Cell Invasion |
9:00 am - 9:10 am | Discussion Leader: Louis H. Miller (NIAID) |
9:10 am - 9:40 am | Chetan Chitnis (ICGEB)
"Signaling pathways for regulation of microneme release during erythrocyte invasion by malaria parasites"
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9:40 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Julian Rayner (Wellcome Trust Sanger Institute)
"Receptor-ligand interactions during Plasmodium falciparum erythrocyte invasion"
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10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:10 am | Paul Gilson (Burnet Institute)
"A hierarchy of receptor-ligand interactions in malaria parasite invasion and their association with deformation, calcium influx and dehydration of host erythrocytes"
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11:10 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Mike Blackman (National Institute for Medical Research)
"Advances in understanding of malaria parasite egress from its host cell"
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11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Bruce Russell (Vivax Malaria Laboratory)
"Vivax Invasion and Development in Human Reticulocytes"
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12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Martin Boulanger (University of Victoria)
"Structural and biochemical characterization of Plasmodium falciparum 12 (Pf12) reveals a unique inter-domain organization and the potential for an antiparallel arrangement with Pf41"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Liver Stage |
5:30 pm - 5:40 pm | Discussion Leader: Maria Mota (University of Lisbon) |
5:40 pm - 6:10 pm | Photini Sinnis (Johns Hopkins Bloomberg School of Public Health)
"Late liver stages: a role for falcipain-1 in hepatic merozoite infectivity"
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6:10 pm - 6:20 pm | Discussion |
6:20 pm - 6:40 pm | Sangeeta Bhatia (Massachusetts Institute of Technology)
"Hepatic Tissue Engineering for Modeling Liver Stage Malaria"
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6:40 pm - 6:50 pm | Discussion |
6:50 pm - 7:05 pm | Stefan Kappe (Seattle BioMed)
"Plasmodium vivax infection in mice with humanized livers"
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7:05 pm - 7:10 pm | Discussion |
7:10 pm - 7:25 pm | Miles Davenport (UNSW, Centre For Vascular Research)
"Does blood stage P. falciparum suppress liver stage infection?"
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7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Whole Genome Analyses |
9:00 am - 9:10 am | Discussion Leader: Jane Carlton (New York University) |
9:10 am - 9:40 am | Dyann Wirth (Harvard School of Public Health)
"Harnessing genomics and genome biology to understand malaria biology" |
9:40 am - 9:50 am | Discussion |
9:50 am | Coffee Break |
10:30 am - 11:00 am | Dominic Kwiatkowksi (Wellcome Trust Sanger Institute)
"Watching the parasite genome evolve and trying to do something about it" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Zybnek Bozdek (Nanynag Technological University)
"Transcriptome analyses of artemisinin resistant malaria emerging in the Greater Mekong Region" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Karine Le Roch (University of California)
"The spatial organization of the Plasmodium genome throughout its infectious cycle" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Lia Chappell (Wellcome Trust Sanger Institute)
"Directional, amplification-free RNA-seq of a Plasmodium knowlesi in vivo time course" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Heather Painter (Lewis-Sigler Institute)
"Real-time Global Transcriptional Dynamics of Plasmodium falciparum Throughout Intraerythrocytic Development" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Immunity |
5:30 pm - 5:40 pm | Discussion Leader: Jean Langhorne (MRC National Institute for Medical Research) |
5:40 pm - 6:00 pm | Kevin Marsh (Nuffield Dept of Clinical Medicine)
"Naturally acquired immunity to malaria in endemic populations"
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6:00 pm - 6:10 pm | Discussion |
6:10 pm - 6:30 pm | Eleanor Riley (LSHTM)
"Generation and maintenance of humoral immunity to malaria"
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6:30 pm - 6:40 pm | Discussion |
6:40 pm - 7:00 pm | Bill Heath (University of Melbourne)
"Antigen presentation and development of T cell memory in murine malaria"
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7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:25 pm | Christian Engwerda (Queensland Institute of Medical Research)
"The regulation of CD4+ T cell responses during malaria"
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7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
9:00 am - 12:30 pm | Malaria Vaccine Development |
9:00 am - 9:10 am | Discussion Leader: Robert Sauerwein (Radboud University Nijmegen Medical Centre) |
9:10 am - 9:40 am | Marcel Tanner (Swiss Tropical Institute)
"Status of RTS,S as malaria vaccine" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:05 am | Simon Draper (University of Oxford)
"Malaria Vaccine Development against the Blood-Stage" |
10:05 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:00 am | Anja Scholzen (Radboud University Nijmegen Medical Centre)
"Immune signatures induced by Chloroquine Prophylaxis and Sporozoite immunization in human volunteers" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Michael Good (Griffith University)
"Strategies for developing and testing chemically attenuated blood stage parasites as vaccines" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | Toshihiro Horii (Osaka University)
"Phase 1b Randomized Trial and Follow-Up Study in Uganda of the Blood-Stage Malaria Vaccine Candidate BK-SE36" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Mary Galinski (Emory University)
"Malaria Host-Pathogen Interaction Center - MaHPIC" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Physiology and Biochemistry of Malaria |
5:30 pm - 5:40 pm | Discussion Leader: Daniel Goldberg (Howard Hughes Medical Institute) |
5:40 pm - 6:10 pm | Andy Waters (University of Glasgow)
"Inducible, iterative and rapid protein inactivation in Plasmodium"
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6:10 pm - 6:20 pm | Discussion |
6:20 pm - 6:40 pm | Sylke Muller (University of Glasgow)
"Plasmodium falciparum phosphoenolpyruvate carboxylase identified as a key enzyme in redox maintenance and energy generation"
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6:40 pm - 6:50 pm | Discussion |
6:50 pm - 7:05 pm | Sujaan Das (MRC National Institute For Medical)
"Functional analysis of Plasmodium falciparum merozoite surface protein 1"
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7:05 pm - 7:10 pm | Discussion |
7:10 pm - 7:25 pm | Andrew Tobin (University of Leicester)
"Progress towards targeting the malaria kinome"
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7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |