Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Drug Development and Resistance |
| Discussion Leader: Sirima Sodiomon Bienvenu (The National Center for Research and Training on Malaria, Burkina Faso) |
7:40 pm - 7:50 pm | Introduction by Discussion Leader |
7:50 pm - 8:05 pm | Arjen Dondorp (Mahidol University, Thailand) "Artemisinin Resistance" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:30 pm | Thierry Diagana (Novartis Institute for Tropical Diseases, Singapore) "Advances in Antimalarial Drug Discovery and Development" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:55 pm | Abdoulaye Djimde (University of Science and Technologies, Mali) "P. falciparum Resistance to Artemisinins: Any Worries
for Sub-Saharan Africa?" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Didier Leroy (Medicines for Malaria Venture, Switzerland) "Surmounting Drug Resistance with Next-Generation Antimalarials: Medicines for Malaria Venture's R&D Portfolio" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | (Molecular) Biology of Asexual and Sexual Stage Parasites |
| Discussion Leader: Andy Waters (Wellcome Trust Centre for Molecular Parasitology, United Kingdom) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Alexandra Rowe (University of Edinburgh, United Kingdom) "PfEMP1 Interactions with Erythrocyte and Endothelial Cell Receptors in Severe Malaria" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Matthias Marti (Harvard T.H. Chan School of Public Health, USA) "Mechanisms of Gametocyte Formation and Tissue Sequestration in Plasmodium falciparum" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:00 am | Tania De Koning-Ward (Deakin University, Australia) "Host Cell Remodelling by Malaria Parasites" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Pietro Alano (Institute of Public Health, Italy) "Plasmodium Falciparum Gametocyte Development and Interplay with the Human Host" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | Julian Rayner (Wellcome Trust Sanger Institute, United Kingdom) "Genome Scale Experimental Genetic Screening of Plasmodium Parasites" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | Poster Previews |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Immunology in the Lab and in the Field |
| Discussion Leader: James Beeson (Burnet Institute, Australia) |
6:00 pm - 6:20 pm | Introduction by Discussion Leader |
6:20 pm - 6:35 pm | Peter Crompton (National Institute of Allergy and Infectious Disease, NIH, USA) "T Follicular Helper Cell Response to Malaria: Potential Implications for Vaccine Design" |
6:35 pm - 6:45 pm | Discussion |
6:45 pm - 7:00 pm | James Beeson (Burnet Institute, Australia) "Defining Key Mechanisms of Human Immunity to Malaria to Advance Vaccine Development" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:25 pm | Yunshan Goh (Singapore Immunology Network, Singapore) "Breadth of the Humoral Response and Potential Vaccine Targets Following Experimental Plasmodium falciparum Sporozoite Inoculation in Humans" |
7:25 pm - 7:35 pm | Discussion |
7:35 pm - 7:50 pm | Douglas Golenbock (University of Massachusetts Medical School, USA) "Innate Immune Responses Against Plasmodium" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Models in Animals and Humans |
| Discussion Leader: Stefan Kappe (Seattle Biomedical Research Institute, USA) |
9:00 am - 9:15 am | Introduction by Discussion Leader |
9:15 am - 9:35 am | Stefan Kappe (Seattle Biomedical Research Institute, USA) "Bridging Animal Models and Human Malaria Research with Humanized Mice" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:05 am | Clemens Kocken (Biomedical Primate Research Centre, The Netherlands) "Non-Human Primate Models for P. vivax Malaria" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Else Bijker (Radboud University Nijmegen Medical Centre, The Netherlands) "Chemoprophylaxis and Sporozoites Immunization: A Valuable Model to Study Protective Immunity in Humans" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:30 am | Philip Spence (University of Edinburgh, United Kingdom) "Using Mosquitoes to Unlock Immunity to Malaria" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Sangeeta Bhatia (Massachusetts Institute of Technology, USA) "Engineered Hepatic Tissues for Modeling Liver Stage Malaria" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | James McCarthy (QIMR Berghofer Medical Research Institute, Australia) "Life Cycle Specific Transcripts in Plasmodium
falciparum Malaria" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Pregnancy Associated Malaria |
| Discussion Leader: Patrick Duffy (National Institute of Allergy and Infectious Disease, NIH, USA) |
6:00 pm - 6:10 pm | Introduction by Discussion Leader |
6:10 pm - 6:30 pm | Feiko Ter Kuile (Liverpool School of Tropical Medicine, United Kingdom) "SP Resistance and Alternative Strategies for the Control of Malaria in Pregnancy" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 7:00 pm | Alfredo Mayor (Barcelona Centre for International Health Research, Spain) "Targeting Pregnant Women to Asses Malaria Transmission" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:30 pm | Philippe Boeuf (Burnet Institute, Australia) "Mechanisms of Fetal Growth Restriction in Placental Malaria" |
7:30 pm - 7:40 pm | Discussion |
7:40 pm - 7:55 pm | Danny Milner (Brigham and Women's Hospital, USA) "Pediatric Cerebral Malaria Pathology from Autopsy to Genetics" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Vaccines Tested in Controlled Human Malaria Infections and in the Field |
| Discussion Leader: Salim Abdulla (Ifakara Health Institute, Tanzania) |
9:00 am - 9:15 am | Introduction by Discussion Leader |
9:15 am - 9:35 am | Johan Vekemans (GlaxoSmithKline Vaccines, Belgium) "Building on RTS,S: Towards an Improved Second Generation Malaria Vaccine" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Stephen Hoffman (Sanaria Inc., USA) "A Highly Effective PfSPZ Vaccine in Our Time: Progress, Challenges, and Timeline for Licensure" |
10:10 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 11:15 am | Adrian Hill (Jenner Institute, University of Oxford, United Kingdom) "Towards Multi-Component Subunit Vaccines for Malaria" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Simon Draper (Jenner Institute, University of Oxford, United Kingdom) "The Latest Developments of Vaccines Against the Blood-Stage Parasite" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Miguel Prudencio (Instituto de Medicina Molecular, Portugal) "Towards Clinical Evaluation of a Rodent Plasmodium-Based Vaccine Against Human Malaria" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Severe
Malaria and Pathophysiology
|
| Discussion Leader: Nick Anstey (Menzies School of Health Research, Australia) |
6:00 pm - 6:10 pm | Introduction by Discussion Leader |
6:10 pm - 6:30 pm | Andre Siqueira (National Institute of Infectious Diseases, Brazil) "The Clinical Burden of Vivax Malaria" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 7:00 pm | Mats Wahlgren (Karolinska Institutet, Sweden) "Roles of RIFINs and PfEMP1 in P. Falciparum Sequestration" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:30 pm | Maria Mota (Instituto de Medicina Molecular, Portugal) "Nutrient Sensing Modulates Plasmodium Virulence" |
7:30 pm - 7:40 pm | Discussion |
7:40 pm - 8:00 pm | Poster Previews |
8:00 pm | Dinner |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Transmission Stages in Humans and Mosquitoes |
| Discussion Leader: Chris Drakeley (London School of Hygiene and Tropical Medicine, United Kingdom) |
9:00 am - 9:15 am | Introduction by Discussion Leader |
9:15 am - 9:35 am | Elena Levashina (Max Planck Institute for Infection Biology, Germany) "Mosquito Factors that Restrict Plasmodium Development in the Mammalian Host" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:05 am | Teun Bousema (Radboud University Nijmegen Medical Centre, The Netherlands) "Defining the Human Infectious Reservoir for Malaria" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:35 am | Azra Ghani (Imperial College London, United Kingdom) "The Implications of the
P.falciparum Infectious Reservoir for Malaria Elimination Strategies" |
10:35 am - 10:45 am | Discussion |
10:45 am - 11:15 am | Coffee Break |
11:15 am - 11:30 am | Flaminia Catteruccia (Harvard T.H. Chan School of Public Health, USA) "Reproduction and Plasmodium Transmission by the Anopheles Vector" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Ingrid Felger (Swiss Tropical and Public Health Institute, Switzerland) "Transmission Dynamics of
P. falciparum and P. vivax - Molecular Approaches" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Alassane Dicko (University of Bamako, Mali) "Dose Escalation Study of Safety and Efficacy of Low Single-Dose Primaquine for Gametocytocidal Activity Against P. falciparum in Mali" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Biology of Sporozoites and Liverstages |
| Discussion Leader: Maria Mota (Instituto de Medicina Molecular, Portugal) |
6:00 pm - 6:10 pm | Introduction by Discussion Leader |
6:10 pm - 6:30 pm | John Harty (University of Iowa, USA) "CD8 T Cell Immunity to Plasmodium Liver Stage Infection" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 7:00 pm | Valerie Soulard (Centre d Immunologie et des Maladies Infectieuses, France) "Investigation of CD8 T-Cell Responses Against Plasmodium In Vitro and In Vivo" |
7:00 pm - 7:05 pm | Discussion |
7:05 pm - 7:25 pm | Justin Boddey (The Walter and Eliza Hall Institute, Australia) "An Inhibitor of Erythrocyte Invasion Blocks P. falciparum Invasion and Traversal of Hepatocytes" |
7:25 pm - 7:30 pm | Discussion |
7:30 pm - 7:40 pm | Marvin Duvalsaint (University of South Florida, USA) "Phytohormones and the Role of the Apicoplast in Dormancy in the Erythrocytic Stages of Plasmodium falciparum" |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Zenon Zenonos (Wellcome Trust Sanger Institute, United Kingdom) "Basigin Is a Druggable Target for Host Oriented Anti-Malarial Interventions" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |