Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Progress and Next Steps in Understanding the Parasite, Vector and Host
This session will be composed by lectures of leaders in the field that will put in perspective the past achievements and present challenges of malaria research, setting the tone for the entire conference and scientific discussions.
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Can a Pfs47-Based Vaccine Recruit the Mosquito Immune System to Disrupt Malaria Transmission?"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Dissecting Protective Immune Mechanisms Against PE Stages"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Understanding Red Blood Cell Infection and Pathogenicity"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Within the Mosquito Vector, Basic Biology
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Studying Anopheles -Plasmodium Interactions: From Basic Research to Applications for Malaria Control"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Environmental and Genetic Factors in Mosquito Resistance to Plasmodium "
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Regulation of Sexual Development in P. berghei "
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
"Photosensitized INA-Labelled Protein 1 (PhIL1) Is a Novel Component of the Inner Membrane Complex of All Invasive and Motile Stages of Plasmodium "
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"A Plasmodium ABC Transporter Plays an Essential Role in the Uptake of Lipid to the Developing Oocyst"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum "
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Beyond the Bench of the Plasmodium -Anopheles Interactions
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Sand Fly Molecules Controlling the Development of Transmissible Infections"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"An Ancient Plant and Animal Hormone Functions as a Transmission Blocking Therapeutic to Control Immunity to Erythrocytic and Sporogonic Stages of Plasmodium falciparum "
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
"Human to Mosquito Transmission of P. falciparum and P. vivax During Controlled Human Malaria Infection"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:45 pm
"Exploring Strategies for Plasmodium Suppression in the Mosquito"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Basic Biology of the Pre-Erythrocytic Stages
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Polarizing Challenges for Hepatocytes and Malaria"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"New Insights into Host Cell and Parasite Determinants of Plasmodium Sporozoite Entry into Hepatocytes"
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
"Establishment of Malaria Infection: Transmission Dynamics and Roadblocks"
10:55 am - 11:00 am
Discussion
11:00 am - 11:10 am
"O-Glycosylation of Sporozoite Thrombospondin Repeats Is Required for Liver Infection by Plasmodium falciparum "
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Perturbation of Plasmodium vivax Hypnozoite Formation, Growth and Reactivation In Vivo in a Human-Liver Chimeric Mouse"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Factors Defining the Ability of a Liver-Stage Malaria Antigen to Reactivate Protective CD8+ T Cell Responses"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Non-Classical Antibodies to Prevent Malaria Infection"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Phenotypic Analysis of KO Parasites for Genes Identified by High-Throughput Screening"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
The Pre-Erythrocytic Stages, Beyond the Bench
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"New Insights into Cell-Specific Innate Immunity"
6:30 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Preventing Pre-Erythrocytic Malaria Infection"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Why Don't We Make Better Antibody and B Cell Responses to the Circumsporozoite Protein?"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:45 pm
"Finding New Compounds that Kill Liver Stage Parasites"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Malaria Blood Stage Biology
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Killer Lymphocytes Recognize and Kill Blood Stage Falciparum Malaria and Other Protozoan Parasites"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Immune Regulation During Blood-Stage Plasmodium -Infection"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Mechanisms of Action of and Resistance to Artemisinins"
11:00 am - 11:05 am
Discussion
11:05 am - 11:25 am
"A New Invasion Pathway for Plasmodium vivax Entry into Reticulocytes"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Is HSP101 the PTEX Unfoldase?"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Phospho-Signalling Pathways in Malaria Parasite During Host Cell Invasion"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"A Functional Genetics Toolkit for Human Malarial Parasites"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Blood Stage Malaria Biology Moved Forward
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Using Systems Tools to Define Correlates of Humoral Immunity Against Malaria"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Toward Anti-Malarial Drugs Targeting Host Red Blood Cell Remodelling"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
"Plasmodium falciparum Dipeptidyl Aminopeptidase 3 Is Important for Efficient Attachment of Merozoites to Erythrocytes"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:45 pm
"Towards a Broadly-Neutralising Vaccine Against the P. falciparum Merozoite"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Emerging Themes in Pathogenesis and Host Defense
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Microbiota and Respiratory Disease"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Contributions of the Intestinal Microbiota to Severe Malaria"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Disease Tolerance as a Defence Strategy Against Malaria"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
"The Role of Antigen-Presenting Reticulocytes During Malaria"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Dietary Alterations Modulate the Establishment of Plasmodium Infection"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Toxoplasma gondii Infection Reprograms Monocyte Motility to Favor Migration Within 3D Substrates, Suggesting a Role in Enabling Tissue Dissemination"
11:50 am - 11:55 am
Discussion
11:55 am - 12:15 pm
"Plasmodium Products Persist in the Bone Marrow and Promote Chronic Bone Loss"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Enabling Tools for Malaria Research
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"From Single Molecules to Life: Quantitative Microscopy at the Nanoscale"
6:30 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Single Cell Profiling of Plasmodium Phenotypic Heterogeneity"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"How Bioengineering Can Help Us?"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Using the Unusual Reproductive Genetics of Plasmodium to Facilitate Phenotypic Analysis in the Parasite Liver Stages"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Brain-on-a-Chip: New Tools to Study Cerebral Malaria"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
General Discussion
7:55 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure