Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Scientific Challenges and Opportunities in the Face of Shifting Malaria Epidemiology
Although some countries are accelerating toward malaria elimination, the unprecedented decline in malaria cases and deaths since the turn of the century has stalled or even reversed in other regions. In light of this concerning trend, speakers in this session will share their perspectives on key questions, challenges and opportunities for the malaria research community.
Discussion Leader: Chandy John (Indiana University School of Medicine, USA)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Azra Ghani (Imperial College London, United Kingdom)
"Getting Back on Track: The Tools and Strategies Needed to Achieve Malaria Elimination and Eradication"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Rose Leke (University of Yaoundé I, Cameroon)
"What Can the Malaria Community Learn from the Polio Eradication Effort?"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Philip Welkhoff (Bill & Melinda Gates Foundation, USA)
"The Role of Prevention of Transmission, Improved Case Management, and Enhanced Surveillance for Both Burden Reduction and Eventual Elimination"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Antimalarial Drug Resistance and Drug Development
The emergence and spread of suboptimal responses to antimalarial drugs jeopardizes patient safety and hinders elimination efforts. This session will focus on cutting-edge advances in understanding and managing drug resistance and will also review promising new antimalarial drugs in the pipeline.
Discussion Leader: Susan Charman (Monash University, Australia)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Timothy Wells (Medicines for Malaria Venture, Switzerland)
"Medicines in the Control and Eradication of Malaria"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
Esther Schmitt (Novartis Pharma AG, Switzerland)
"Clinical Development of the Novel Antimalarial Agents Cipargamin (KAE609) and Ganaplacide (KAF156)"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Elizabeth Winzeler (University of California, San Diego, USA)
"Using the Malaria Drug Accelerator to Find New Targets for Malaria Elimination"
10:15 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
David Fidock (Columbia University Medical Center, USA)
"Recent Insights into the Molecular Basis of P. falciparum Resistance to Artemisinin-Based Combination Therapy Drugs"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
Laurent Dembele (University of Sciences, Techniques and Technologies of Bamako (USTTB), Mali)
"Toward Novel Antimalarials to Prevent the Spread of Artemisinin Resistant Parasites to Africa"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Adrianus Dondorp (Mahidol Oxford Tropical Medicine Research Unit, Thailand)
"Triple Artemisinin Combination Therapies: A New Paradigm for Treatment of Malaria?"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Zbynek Bozdech (Nanynag Technological University, Singapore)
"The Biology and Transcriptomic Profiles of Artemisinin-Resistant P. falciparum "
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Azra Ghani (Imperial College London, United Kingdom) and Faith Osier (Heidelberg University, Germany)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Improving Treatment for Patients with Severe Malaria
In-hospital case fatality rates for severe malaria remain unacceptably high. This session will highlight progress toward understanding malaria pathogenesis and the development of urgently needed interventions to improve patient outcomes.
Discussion Leader: Terrie Taylor (Michigan State University, USA)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:20 pm
Nicholas Anstey (Menzies School of Health Research, Australia)
"Glycocalyx Degradation and the Pathophysiology of Severe Falciparum Malaria"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:40 pm
Benoit Gamain (INSERM, France)
"Recent Molecular Insights into Pregnancy-Associated Malaria and Progress Toward a Vaccine"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:00 pm
Kathryn Maitland (Imperial College London, United Kingdom)
"Cotrimoxazole or Multi-Mineral Multi-Vitamins to Improve Post-Discharge Outcomes Following Severe Anaemia in African Children"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:20 pm
James Watson (Mahidol Oxford Tropical Medicine Research Unit, Thailand)
"Causal Pathways in Severe Falciparum Malaria"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:40 pm
Hans Ackerman (National Institute of Allergy and Infectious Diseases, NIH, USA)
"The Association of Blood Transfusion with Outcome in African Children with Severe Malaria: A Multicenter Observational Study"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
General Discussion: Defining the Role of Blood Transfusion in Severe Malaria
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Progress Toward Malaria Vaccines that Prevent Infection and Disease
Session in memory of Ruth Nussenzweig and Ogobara Doumbo . Malaria vaccines that protect against infection and disease are urgently needed. This session will focus on the current status of leading liver- and blood-stage malaria vaccine candidates and also highlight novel vaccine strategies.
Discussion Leaders: Robert Sauerwein (Radboud University Medical Center, The Netherlands) and Robert Seder (National Institute of Allergy and Infectious Diseases, NIH, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
Ashley Birkett (PATH's Malaria Vaccine Initiative, USA)
"Recent Developments with RTS,S"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
Simon Draper (Jenner Institute, University of Oxford, United Kingdom)
"Defining an Effective Antibody Response Against the RH5 Invasion Complex"
9:50 am - 10:00 am
Discussion
10:00 am - 10:25 am
Coffee Break
10:25 am - 10:40 am
Meta Roestenberg (Leiden University Medical Center / Radboud University Medical Center, The Netherlands)
"Whole Sporozoite Immune Responses, Immunity and Protection"
10:40 am - 10:50 am
Discussion
10:50 am - 11:05 am
Stefan Kappe (Seattle Children's Research Institute, USA)
"Next Generation Genetically Engineered Whole Parasite Vaccines"
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
Patrick Duffy (LMIV, National Institute of Allergy and Infectious Diseases, NIH, USA)
"Protection Against Heterologous Sporozoite Challenge with Two PfSPZ Chemoprophylaxis Vaccination Regimens"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Adrian Hill (University of Oxford, United Kingdom)
"Can Liver-Targeted Viral Vectors Compete with or Complement Anti-Sporozoite Subunit Vaccines?"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
General Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Informing Next-Generation Vaccines Through Advances in Plasmodium Biology and Immunology
The development of highly effective malaria vaccines remains challenging. This session will feature advances in Plasmodium biology and immunology that are informing malaria vaccine research—from the discovery of human monoclonal antibodies with unusual breadth and potency against Plasmodium parasites, to new insights into Plasmodium biology that could be exploited to improve vaccine efficacy.
Discussion Leaders: Marie Pancera (Fred Hutchinson Cancer Research Center / Vaccine Research Center, NIAID, NIH, USA) and Jean-Philippe Julien (The Hospital for Sick Children, Canada)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
Hedda Wardemann (German Cancer Research Center, Germany)
"Evolution of the Human B Cell Antibody Response to Plasmodium falciparum Circumsporozoite Protein"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
Robert Seder (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Mechanisms of Malaria Monoclonal Antibodies and Future Clinical Development"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:20 pm
Li Jin Chan (Walter and Eliza Hall Institute of Medical Research, Australia)
"Isolation and Characterization of Naturally Acquired Human Monoclonal Antibodies to Plasmodium vivax Adhesin PvRBP2b Reveals Functional Blocking Antibodies"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:45 pm
Antonio Lanzavecchia (Università Della Svizzera Italiana, Switzerland)
"Recent Insights into the Antibody Response to Malaria"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Approaches to Disrupting Malaria Transmission Through Vector Control
Vector control is an essential component of malaria control and elimination, yet current interventions are threatened by the emergence and spread of insecticide resistance. This session will include front-line research on the biology and epidemiology of insecticide resistance and the development of new approaches to disrupt malaria transmission.
Discussion Leader: Nafomon Sogoba (ICER-Mali / FMOS / University of Sciences, Techniques and Technologies of Bamako (USTTB), Mali)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:20 am
Thomas Churcher (Imperial College London, United Kingdom)
"Assessing the Efficacy of Novel Vector Control Tools in the Field and Why We Need Them"
9:20 am - 9:30 am
Discussion
9:30 am - 9:45 am
Sarah Moore (Swiss Tropical and Public Health Institute, Switzerland)
"Getting the Most from Core Vector Control Tools: The New Vector Control Product Pipeline"
9:45 am - 9:55 am
Discussion
9:55 am - 10:05 am
Bilgo Etienne (IRSS/Centre Muraz, Burkina Faso)
"A New Generation of Biological Insecticides: Genetically Engineering Fungi to Prevent Malaria Transmission in Burkina Faso"
10:05 am - 10:10 am
Discussion
10:10 am - 10:25 am
Douglas Paton (Harvard T.H. Chan School of Public Health, USA)
"Killing Parasites Within the Anopheles Female as a New Strategy for Malaria Control"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Carolina Barillas-Mury (National Institutes of Health, USA)
"Plasmodium Evasion of Mosquito Immunity Enhances Malaria Transmission"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Mercy Opiyo (Barcelona Institute for Global Health, Spain)
"The Protective Gap of Indoor Residual Spraying (IRS): Wall Modifications After Spraying Affects Actual Coverage and Hampers Malaria Elimination Efforts"
11:40 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Adriana Adolfi (University of California, Irvine, USA)
"Mosquito Population Modification and Malaria Control"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Exploiting Advances in Gametocyte Research to Disrupt Malaria Transmission
This session will focus on new discoveries in gametocyte epidemiology and biology that can be translated into interventions that reduce Plasmodium transmission in populations. The session will also cover advances in candidate transmission-blocking drugs and vaccines that are currently in clinical development.
Discussion Leaders: Linda Amoah (Noguchi Memorial Institute for Medical Research, University of Ghana, Ghana) and Patrick Duffy (LMIV, National Institute of Allergy and Infectious Diseases, NIH, USA)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
Matthias Marti (University of Glasgow, United Kingdom)
"Investigating Anti-Gametocyte Immunity as a Basis for Novel Transmission Blocking Interventions"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
Issaka Sagara (University of Sciences, Techniques and Technologies of Bamako (USTTB), Mali)
"Field Trials of Malaria Transmission Blocking Vaccines"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:20 pm
Zuleima Pava Imitola (QIMR Berghofer Medical Research Institute, Australia)
"Investigating Human to Mosquito Transmission of Artemisinin-Resistant P. falciparum Parasites in the Induced Blood Stage Malaria Model"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:45 pm
Teun Bousema (Radboud University Medical Center, The Netherlands)
"The Asymptomatic Reservoir: A Silent Threat?"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Genetic Epidemiological Surveillance of the Parasite and Vector
This session will review the latest advances in genetic epidemiological surveillance of the parasite and vector to detect, measure and track changes in malaria transmission, drug and insecticide resistance, 'diagnostic resistant' malaria, and the submicroscopic parasite reservoir.
Discussion Leaders: Abdoulaye Djimde (University of Sciences, Techniques and Technologies of Bamako, Mali) and Daniel Neafsey (Harvard T.H. Chan School of Public Health, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Ingrid Felger (Swiss Tropical and Public Health Institute, Switzerland)
"Insights into P. falciparum Infection Dynamics Gained by Deep Sequencing"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
Aimee Taylor (Harvard T.H. Chan School of Public Health, USA)
"Estimating Relatedness Between Malaria Parasites"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Alfred Ngwa (Medical Research Council Unit The Gambia at LSHTM, Gambia)
"Plasmodium falciparum Variation Spanning Three Decades and Across The Gambia"
10:15 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Silvia Portugal (Heidelberg University Hospital, Germany)
"The P. falciparum Dry Season Reservoir: A Long Game of Hide and Seek"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
Martin Donnelly (Liverpool School of Tropical Medicine, United Kingdom)
"Genomic Surveillance of Malaria Vector Control Campaigns in Sub-Saharan Africa"
11:40 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Olivo Miotto (Mahidol Oxford Tropical Medicine Research Unit, Thailand)
"Use of Genetic Epidemiology in Malaria Elimination in the Greater Mekong Subregion "
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Leveraging Scientific Advances to Reverse Resurgent Malaria and Accelerate Elimination
In this session leaders in the field will summarize major themes of the conference and facilitate a discussion of key areas in which scientific advances are needed to reverse resurgent malaria and accelerate elimination.
Discussion Leaders: Faith Osier (Heidelberg University, Germany) and Brendan Crabb (Burnet Institute, Australia)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Brian Greenwood (London School of Hygiene & Tropical Medicine, United Kingdom)
"Research into Practice: The Story of the Use of Antimalarials to Prevent Malaria in African Children"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Adrianus Dondorp (Mahidol Oxford Tropical Medicine Research Unit, Thailand)
"Eliminating Malaria in the Greater Mekong Subregion, the Cradle of Drug Resistance"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:40 pm
Dyann Wirth (Harvard T.H. Chan School of Public Health, USA)
"Malaria Research in the Era of Eradication: Opportunities and Challenges"
7:40 pm - 7:50 pm
Discussion
7:50 pm - 7:55 pm
General Discussion
7:55 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure