Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Technology and Drug Development
Discussion Leaders: Debakshi Mullick (Weizmann Institute of Science, Israel) and Kristina Burrack (University of Minnesota, USA)
3:15 pm - 3:25 pm
Maria Penzo (London School of Hygiene and Tropical Medicine, United Kingdom)
"High-Throughput Screening to Develop New Inhibitors Against the Plasmodium falciparum Cyclic GMP-Dependent Protein Kinase"
3:25 pm - 3:30 pm
Discussion
3:30 pm - 3:40 pm
Maria Bernabeu (Center for Infectious Disease Research, USA)
"3D Brain Microvessel Models for the Study of Cerebral Malaria Pathogenesis"
3:40 pm - 3:45 pm
Discussion
3:45 pm - 3:55 pm
Thao-Thy Pham (Rega Institute for Medical Research, KU Leuven, Belgium)
"Improved Method for Quantification of Malaria Parasite Sequestration in Tissues"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Host-Parasite Interactions
Discussion Leaders: Omar Janha (University of Glasgow, United Kingdom) and Peter Crompton (National Institute of Allergy and Infectious Diseases, NIH, USA)
5:30 pm - 5:40 pm
Dora Posfai (Duke University, USA)
"Aquaporin-3 an Essential Host Protein for the Development of Liver Stage Malaria"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
Katharine Collins (QIMR Berghofer Medical Research Institute, Australia)
"Human to Mosquito Transmission of Plasmodium falciparum and Plasmodium vivax During Controlled Human Malaria Infection"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
E. Nicole Arroyo (University of Washington, USA)
"The CD4+ T Cell Response to Murine Malaria Is Dominated by a Long-Lasting Tfh Phenotype"
6:10 pm - 6:20 pm
Discussion
6:20 pm - 6:30 pm
Katherine Cumnock (Stanford University, USA)
"Metabolically Identified Interventions Alter Malaria Severity and Outcome"
6:30 pm - 6:35 pm
Discussion
6:35 pm - 6:45 pm
Paulo Bettencourt (University of Oxford / The Jenner Institute, United Kingdom)
"Plasmodium falciparum NF135 Immunopeptidome in Humanized Mice"
6:45 pm - 6:55 pm
Discussion
6:55 pm - 7:05 pm
Lila Farrington (University of California, San Francisco, USA)
"Frequent Malaria Drives the Up-Regulation of CD16 and Markers of Cytotoxicity on Vd2 T Cells"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
Omar Sheriff (Nanyang Technological University, Singapore)
"Elucidating Protein Interactions Responsible for Host Cell Modification in Plasmodium falciparum Infected RBCs"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Parasite Biology
Discussion Leaders: David Khoury (University of New South Wales, Australia) and Kirsten Hanson (University of Texas at San Antonio, USA)
9:00 am - 9:10 am
Anna Barcons-Simon (Institut Pasteur, France)
"The Trans-Acting GC-Rich Non-Coding RNA Regulates Monoallelic var Gene Expression in Plasmodium falciparum "
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Nanika Coetzee (University of Pretoria, South Africa)
"Exploiting the Epigenomic and Proteomic Complexity of Plasmodium falciparum Gametocytogenesis"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Marta Walczak (Stanford University, USA)
"Atg8, How Plasmodium Borrows Autophagy Machinery for Apicoplast Biogenesis"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Hao Yang (Australian National University, Australia)
"Role of Human Hydroxymethylbilane Synthase (hHMBS) in the Plasmodium falciparum "
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Kristina Burrack (University of Minnesota, USA)
"IL-15 Complex-Stimulated NK Cells Protect Mice from Cerebral Malaria"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Anush Chiappino-Pepe (Ecole Polytechnique Federale de Lausanne, Switzerland)
"Identifying and Targeting Key Cellular Mechanisms for Proliferation in Plasmodium Parasites: A Combined Experimental and Computational Strategy"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Hilde von Grüning (University of Pretoria, South Africa)
"Toward CRISPR-Cas9 Evaluation of Putative Cell Cycle Regulators of the Plasmodium falciparum Parasite"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Ana Sanchez-Azqueta (University of Glasgow, United Kingdom)
"Targeting Protein Kinases in Malaria - The Potential of Inhibition of PfCLK3"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Malaria Pathogenesis
Discussion Leaders: Leen Vandermosten (KU Leuven, Belgium) and Geoffrey Hart (University of Minnesota, USA)
1:30 pm - 1:40 pm
Pamela Odorizzi (University of California, San Francisco, USA)
"Investigating the Impact of In Utero Malaria Exposure on CD4+ T Cell Immunity in Infants"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
Olivia Swann (Centre for Immunity, Infection and Evolution, United Kingdom)
"Neighbouring Polymorphisms in Complement Receptor 1 (CR1) Have Opposing Associations with Cerebral Malaria in Two Discrete African Case-Control Studies"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
Christine Hopp (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Longitudinal Analysis of Plasmodium falciparum -Specific Atypical and Classical Memory B Cell Responses to Natural Malaria Infection in Children and Adults"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:25 pm
Sarah Boudova (University of Maryland School of Medicine, USA)
"Chronic Placental Malaria Alters Fetal Cytokine Profiles"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
