Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Antimalarial Drug Resistance and Drug Development
3:15 pm - 3:25 pm
"Drug Testing in Volunteer Infection Studies: The Importance of Blood-Stage Parasite Viability in the Investigation of Antimalarial Drug Efficacy"
3:25 pm - 3:30 pm
Discussion
3:30 pm - 3:40 pm
"Understanding Minimal Tool Properties Versus Operational Factors of New Malaria Interventions for Elimination: A Modelling Study"
3:40 pm - 3:45 pm
Discussion
3:45 pm - 3:55 pm
"Target Product Profiles for Malaria Medicines"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Informing Vaccine Development Through Advances in Plasmodium Biology and Immunology
5:30 pm - 5:40 pm
"Immunologic Profiles Defining Clinical States in Malaria"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
"Increased Magnitude and Breadth of Circulating TfH Activation in Adults Compared to Children with Malaria Is Associated with Higher Induction of Functional Antibodies"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
"Altered Immune Responses in Malaria-Exposed Individuals"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
"The Splenic Response to Blood-Stages of the Rodent Malaria Parasite, Plasmodium chabaudi Following Vector Transmission"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"A Hidden Biomass of Non-Phagocytosed Asexual and Sexual Stages of Plasmodium falciparum and P. vivax in the Human Spleen"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"Erythrocyte Remodeling in Plasmodium falciparum Parasites During the Dry Season"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Primary Porcine Hepatocytes as a Novel System for Plasmodium falciparum Infection"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"A Plasmodium falciparum ApiAP2 Factor that Controls Var and Gametocyte Related Gene Transcription"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Vaccine Development / Mentorship Component: Careers in Science
9:00 am - 9:10 am
"Engineered Antibodies Against Plasmodium Transmission from Man to Mosquito"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Characterization of Antimalarial Monoclonal Antibodies Reveals Synergistic Epitopes in the Plasmodium falciparum RH5-CyRPA-Ripr Invasion Complex"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Superior Antigen-Specific T Follicular Helper (Tfh) Cell Responses to Blood-Stage Malaria Antigen RH5 Are Induced with a Protein/AS01 Vaccine Platform as Compared to Heterologous Viral Vectors"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Development of Plasmodium vivax Vietnam-IV Blood Challenge Model Using Aotus Nancymaee Monkeys for Evaluation of Blood-Stage Vaccine Candidates"
9:55 am - 10:00 am
Discussion
10:00 am - 11:00 am
Panel Discussion
Careers in Science
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Understanding Malaria Transmission Dynamics
1:30 pm - 1:40 pm
"Investigating Human to Mosquito Transmission of Artemisinin-Resistant P. falciparum Parasites in the Induced Blood Stage Malaria Model"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
"Performance of Transmission-Blocking Monoclonal Antibodies in DMFA and SMFA and Insights from Single-Oocyst Sequencing"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
"Plasmodium falciparum Immature Gametocytes Development in Human Primary Erythroblasts"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:25 pm
"Field Efficacy of Biolarvicides Applied in Fish Ponds for Malaria Vector Control in a High Transmission Area in the Brazilian Amazon"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes