Sunday, February 2: 7:30 PM - 8:45 PM

KEYNOTE ADDRESS

• 7:30 - M. C. Paterson - Opening remarks
• 7:45 - D. Bootsma - "30 years of DNA repair research: the past, the present and the future"

Monday, February 3: 9:00 AM- Noon

DNA LESION STRUCTURE / REPAIR PROTEIN RECOGNITION

• 9:00 - S. H. Wilson, Discussion Leader - Introduction
• 9:05 - J. A. Tainer - "Structural and mutational analysis of base-excision repair enzymes: DNA damage recognition and cleavage"
• 9:45 - B. van Houten - "The DNA damage recognition problem: principles and proteins of nucleotide excision repair"
• 10:40 - S. Wallace - "Oxidative DNA base lesions and the proteins that recognize them"
• 11:20 - M. J. Smerdon - "DNA damage and nucleosome stability"

Monday, February 3: 7:15 PM - 9:30 PM

DNA REPAIR PATHWAYS I

• 7:15 - E. C. Friedberg, Discussion Leader - Introduction
• 7:20 - S. H. Wilson - "Mechanisms of mammalian base excision repair"
• 8:00 - A. R. Lehmann - "Increasingly complex relationships between NER, transcription and human disorders"
• 8:40 - I. Mellon - "Connections between mismatch repair and transcription-coupled repair"
• 9:05 - P. K. Cooper - "Overlap between BER and NER in transcription-coupled repair of oxidative base damage in human cells"

Tuesday, February 4: 9:00 AM- 12:30 PM

DNA REPAIR PATHWAYS II

• 9:00 - P. C. Hanawalt, Discussion Leader - Introduction
• 9:05 - R. M. Liskay - "MutL homolog functions in yeast and mice"
• 9:45 - A. E. Tomkinson - "Cellular functions of mammalian DNA ligases"
• 10:40 - P. Sung - "Action mechanism of Rad proteins required for recombination and repair"
• 11:20 - J. H. J. Petrini - "The hMre11/hRad50 protein complex in recombinational DNA repair"
• 12:00 - R. Jessberger - "SMC (structural maintenance of chromosomes) proteins are components of a mammalian DNA recombinational repair activity"

Tuesday, February 4: 7:15 PM - 9:30 PM

DNA REPAIR/BIOLOGICAL DIVERSITY / ENVIRONMENTAL GENOTOXICITY

• 7:15 - R. B. Setlow, Discussion Leader - Introduction
• 7:20 - J. Hays - "Plant genetic-stability functions: photoreactivation and mismatch repair"
• 7:55 - A. Yasui - "Diversity of excision repair and photolyases for UV damage"
• 8:30 - B. M. Sutherland - "Nucleotide sequence - level photorepair and excision repair in human cells"
• 9:05 - R. Nairn - "UV-B-induced melanoma formation in Xiphorus hybrid fish involves a CDKN2 homologous gene"

Wednesday, February 5: 9:00 AM- 12:30 PM

OXIDATIVE DNA DAMAGE / HUMAN DEGENERATIVE DISEASES

• 9:00 - H. R. Warner, Discussion Leader - Introduction
• 9:05 - R. A. Floyd - "Reactive oxygen species and nitric oxide: influence on neurodegenerative processes"
• 9:45 - L. A. Loeb - "Mutagenesis by oxygen free radicals"
• 10:40 - G. L. Wilson - "Sequence specific repair of oxidative damage in mitochondrial DNA"
• 11:10 - G. M. Martin - "Werner helicase mutations and polymorphisms: relevance for the photobiology of aging"
• 11:50 - M. F. Lavin - "Role of the ATM protein in oxidative signalling"

Wednesday, February 5: 7:30 PM - 9:30 PM

REVIEW OF POSTERS

• 7:30 - V. A. Bohr, J.-M. Egly & F. J. Thoma - Topic A: Nucleotide excision repair/transcription-coupled repair/chromatin structure
• 8:10 - V. M. Maher, G. C. Walker & M. Weinfeld - Topic B: Base excision repair/mismatch repair/mutagenesis
• G. M. Adair, S. P. Lees-Miller & L. H. Thompson - Topic C: Recombination repair/double-strand break repair/DNA-PK

Thursday, February 6: 9:00 AM - 12:35 PM

GENOMIC SURVEILLANCE NETWORK I

• 9:00 - M. S. Meyn, Discussion Leader - Introduction
• 9:05 - J. R. Battista - "Are there DNA damage checkpoints in Deinococcus radiodurans"
• 9:30 - S. H. Friend - "Decoding chemoresponsiveness at the molecular level in yeast"
• 10:10 - W. F. Morgan - "DNA damage induced genomic instability"
• 10:50 - A. M. Carr - "Conservation of DNA checkpoints between yeasts and humans"
• 11:30 - P. M. O'Connor - "Mammalian DNA damage checkpoints: implications for cancer treatment"
• 12:10 - G. G. Poirier - "Potential roles of poly(ADP-ribose) polymerase in DNA repair and apoptosis"

Thursday, February 6: 7:15 PM - 9:30 PM

GENOMIC SURVEILLANCE NETWORK II

• 7:15 - J. E. Cleaver, Discussion Leader - Introduction
• 7:20 - C. W. Anderson - "DNA-PK and the cellular response to DNA damage"
• 8:00 - D. J. Chen - "Role of DNA-PK in double-strand break repair in mammalian cells"
• 8:25 - J. Groden - "New twists in Bloom's syndrome: role of the BLM gene product in DNA repair"
• 9:05 - M. Carreau - "In vivo studies of FAC function"