| Sunday Evening | Keynote Speakers |
- Alexander M. Cruickshank Lecture
Dr. Gregory Verdine, Harvard University
"Deciphering the Epigenetic Code: Toward a Molecular Understanding of DNA Damage Recognition and Removal"
- Phil Hanawalt, Stanford University
"Controlling DNA Excision-Repair Under Stress, or Not"
- Jean-Marc Egly, Institut de Genetique et de Biologie Moleculaire et Cellulaire
"TFIIH, From Transcription and DNA Repair to Clinic"
- John Tainer, The Scripps Research Institute
"A Unified Structural Biology for DNA Repair: Double-Strand Break and Base-Excision Repair Processes"
| Monday Morning | Mouse Models and DNA Repair Defects |
Chair: Errol Friedberg, University of Texas SW Medical Center
"What Mutant Mice Have Taught Us About Global and Transcription-Coupled NER"
- Jan Hoeijmakers, Erasmus University
"DNA Damage Repair: From Living Cells to Mouse Mutants and Human Patients"
- Kiyoji Tanaka, Osaka University
"Skin Carcinogenesis and Developmental Abnormality in DNA Excision Repair-Deficient Mice"
- Raju Kucherlapati, Yeshiva University, Einstein College of Medicine
"The Role of DNA Mismatch Repair Genes in Cancer and Fertility"
- Larry Thompson, Lawrence Livermore National Laboratory
"XRCC1 helps embryos develop by preventing DNA from getting stranded"
- Frederick Alt, HHMI/Children's Hospital, Boston
"Impaired V(D)J Recombination, IgH Class Switching, and Genomic Stability in NHEJ-Deficient Mice"
| Monday Evening | Cellular Responses to Genotoxic Stress |
Chair: Leona Samson, Harvard University School of Public Health
"Complex Cellular Responses to Alkylating Agents"
- Albert Fornace, National Institutes of Health
"The Role for p53-Effector Genes in Global Genomic Repair"
- Carol Prives, Columbia University
"The Roles and Regulation of p53"
- Carl Anderson, Brookhaven National Laboratory
"p53 Posttranslational Modifications: Breaking the Code?
- Stephen Friend, Rosetta Informatics
"Genomic Sensor Pads and Pattern Recognition: Impacting Both the Discovery and Development of Drugs"
- Graham Walker, Massachusetts Institute of Technology
"Closing the Circle: Perspectives on Cellular Responses to DNA Damage"
| Tuesday Morning | Mechanisms of Recombinational and Double-Strand Break Repair |
Chair: Sue Jinks-Robertson, Emory University
"Repair/Bypass of Spontaneous DNA Damage in Yeast"
- Tom Petes, University of North Carolina at Chapel Hill
"Genetic Regulation of Genome Stability in Yeast"
- Christine Richardson, Memorial SLoan-Kettering Cancer Research Center
"Double-strand break repair and chromosomal translocations"
- Patrick Sung, University of Texas Health Science Center at San Antonio
"Mechanisms of RAD52 Group Recombination Factors"
- Richard Fishel, Thomas Jefferson University
"Switching on DNA Repair"
- John Petrini, University of Wisconsin Medical School
"The Mre11 Complex: Linking DNA Recombination and Replication to the Suppression of Malignancy"
| Tuesday Evening | Mechanisms and Pathways in Bulky Lesion Repair |
Chair: Richard Wood, Imperial Cancer Research Center
"Is There a Human NER Repairosome?"
- Gerd P. Pfeifer, City of Hope
"Damage, Repair, and Mutagenesis of Bulky DNA Lesions"
- Miria Stefanini, Istituto di Genetica Biochimica ed Evoluzionistica
"The Repair/Transcription Factor TFIIH: New Insights into the Alterations Resulting in Xeroderma Pigmentosum and Trichothiodystrophy"
- Hanspeter Naegeli, University of Zurich
"Recognition of Bulky Lesions by the Human Nucleotide Excision Repair System"
- Jaap Brouwer, Leiden University
"Transcription Coupled Excision Repair of UV Damage in S. cerevisiae"
- Bennett Van Houten, NIEHS, NIH
"Structure-Function Studies of UvrB, a Protein with a Helicase Fold Adapted for Repair"
| Wednesday Morning | Postreplication Repair of Mismatches and Loops |
Chair: Paul Modrich, Duke University Medical Center
"Mismatch Repair: Exonuclease Involvement and Function in Suppression of Gene Duplications in Human Cells"
- Thomas Kunkel, NIEHS, NIH
"Functional Analysis of Yeast MutS and MutL Homologues"
- Peggy Hsieh, NIDDK, NIH
"Signaling Downstream Events in DNA Mismatch Repair"
- Wei Yang, NIDDK, NIH
"Mechanism of Mismatch Recognition and Repair"
- Titia Sixma, Netherlands Cancer Institute
"Crystal Structures of MutS Bound to a G:T Mismatch; an Asymetric ATPase?"
- Michael Liskay, Oregon Health Sciences University
"MutL Protein Functions During Eukaryotic MMR"
| Wednesday Evening | Lesion Bypass and Novel DNA Polymerases |
Chair: Fumio Hanaoka, Osaka University
"The XPV Gene and Its Product"
- Robert Fuchs, Cancerogenese et Mutagenese Moleculaire et Structurale
"Traffic of DNA Polymerases During Translesion Synthesis"
- Roger Woodgate, NICHD, NIH
"Enzymatic Properties of Human DNA Polymerase i"
- Zvi Livneh, Weizmann Institute of Science
"Lesion Bypass by DNA Polymerase V: Why are Accessory Proteins Needed?"
- Luis Blanco, Universidad Autonoma Madrid
"DNA Polymerases Lambda and Mu, Two Novel Eukaryotic DNA Polymerases Likely Involved in DNA Repair and Variability"
- Myron Goodman, University of Southern California
"Biochemical Basis of SOS-Induced 'Error-Prone' Repair: A 'Cowcatcher' Model for SOS Lesion-Targeted Mutations in E. coli Involving DNA Polymerase V, a Sloppier Copier"
| Thursday Morning | Pathway Coordination in Repair of Oxidatively Damaged DNA and Repair of Mitochondrial DNA |
Chair: Susan Wallace, University of Vermont Medical School
"Complexities of Oxidative Damage Repair"
- Alain Sarasin, Institut de Recherches sur le Cancer
"Transcription-Coupled Repair of 8-Oxo-Guanine in Various Human Diseases"
- Steven Leadon, University of North Carolina at Chapel Hill
"Transcription-Coupled Repair of Oxidative DNA Damage: A Multifunctional Signaling Pathway"
- Daniel Bogenhagen, SUNY, Stony Brook
"DNA Pol Gamma and Mutagenesis of Mitochondrial DNA"
- Sankar Mitra, University of Texas Medical Branch
"Interaction Among Base Excision Repair Proteins in Repair of Oxidative DNA Damage"
- Priscilla Cooper, Lawrence Berkeley National Laboratory
"Pathway Interactions Mediated by XPG Complexes in Transcription-Coupled Repair of Oxidative Damage"
| Thursday Evening | Initiation and Coordination of Endogenous Lesion Repair |
Chair: Tomas Lindahl, Imperial Cancer Research Center
"Removal of Uracil from the Mammalian Genome"
- Erling Seeberg, University of Oslo
"Structure/Function Analysis of DNA Glycosylases with Emphasis on the Human Ogg1 Protein"
- Eugenia Dogliotti, Istituto Superiore Di Sanita
"Base Excision Repair Pathways at Oxidized Bases"
- Yoshihiro Matsumoto, Fox Chase Cancer Center"Replication-Associated Base Excision Repair"
- Tom Ellenberger, Harvard Medical School
"Solutions to the Big Problem of Detecting Small Changes in DNA"
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