| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Presentations |
| 7:30 - 7:40 pm | Introductory remarks |
| 7:40 - 8:30 pm | Alan Lehmann, University of Sussex
"Replication of damaged DNA in mammalian cells: new solutions to an old problem" |
| 8:30 - 9:20 pm | Alan D'Andrea, Dana-Farber Cancer Institute
"The Fanconi Anemia/BRCA Pathway in the DNA damage response" |
| 9:30 - 11:00 pm | Chair's Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | RECOGNITION OF DNA DAMAGE |
| 9:00 - 9:30 am | Greg Verdine, Harvard University
"Structural insights into recognition and repair of lesions in DNA" |
| 9:30 - 10:00 am | Deborah Barnes, Cancer Research UK
"Endogenous DNA damage, repair and the immune system - insights from knockout mice" |
| 10:00 - 10:40 am | Coffee break |
| 10:40 - 11:20 am | Jan Hoeijmakers, Erasmus University
"The role of HR23 proteins in regulating nucleotide excision repair" |
| 11:20 - 11:50 am | Jean Gautier, Columbia University
"DNA damage and DNA replication" |
| 11:50 - 12:20 pm | Sam Wilson, National Institute of Environmental Health Sciences
Discussion Leader |
| 12:30 pm | Lunch |
| 4:00 - 5:30 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | REPAIR OF DNA BASE LESIONS |
| 7:30 - 8:00 pm | Jeffrey Miller, University of California, Los Angeles
"Cancer in knockout mice with combinations of oxidative repair and mismatch repair deficiencies" |
| 8:00 - 8:30 pm | Sheila David, University of Utah
"Functional consequences of inherited MYH variants associated with colorectal cancer" |
| 8:30 - 9:00 pm | Murat Saparbaev, Institut Gustave-Roussy
Characterization of the enzyme involved in nucleotide incision repair pathway" |
| 9:00 - 9:30 pm | Tomas Lindahl, Cancer Research UK
Discussion Leader |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ENCOUNTER OF DNA & RNA POLYMERASES WITH DAMAGE |
| 9:00 - 9:30 am | Sue Jinks-Robertson, Emory University
"Bypass of spontaneous DNA damage by yeast translesion DNA polymerases" |
| 9:30 - 10:00 am | Jesper Svejstrup, Cancer Research UK
"Contending with damage-stalled RNA polymerase II" |
| 10:00 - 10:30 am | Coffee break |
| 10:30 - 11:00 am | Kiyoji Tanaka, Osaka University
"Composition and function of the CSA and XAB2 protein complexes" |
| 11:00 - 11:40 am | Late-breaking developments from poster session |
| 11:40 - 12:20 pm | Graham Walker, Massachusetts Institute of Technology
Discussion Leader |
| 12:30 pm | Lunch |
| 4:00 - 5:30 pm | Poster session I, continued |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SENSITIVITY TO DNA REPLICATION BLOCKS AND DNA CROSS-LINKS |
| 7:30 - 8:00 pm | William Kaufmann, University of North Carolina
"Mechanisms of inhibition of DNA replication by solar UV irradiation" |
| 8:00 - 8:30 pm | Clare McGowan, The Scripps Research Institute
"The role of human Mus81 in DNA repair" |
| 8:30 - 9:00 pm | Steven Brill, Rutgers University
"Sgs 1 and overlapping pathways for replication fork restart in yeast" |
| 9:00 - 9:30 pm | Randy Legerski, M.D. Anderson Cancer Center
Discussion Leader
"Toward reconstitution of mammalian interstrand cross-link repair in vitro" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | RECOMBINATION, DSB, AND MISMATCH REPAIR |
| 9:00 - 9:30 am | Michael Lieber, University of Southern California School of Medicine
"Nonhomologous DNA end-joining in the repair of pathologic and physiologic double-strand breaks" |
| 9:30 - 10:00 am | Cynthia McMurray, Mayo Clinic
"Hijacking mismatch repair to cause CAG expansion mutations in Huntington's Disease" |
| 10:00 - 10:30 am | Coffee Break |
| 10:30 - 11:00 am | Jim Haber, Brandeis University
"Studying DNA repair in yeast to learn about cancer-associated chromosome rearrangements" |
| 11:00 - 11:40 am | Late-breaking developments from poster session |
| 11:40 - 12:20 pm | Patrick Sung, UT Health Science Center, San Antonio
Discussion Leader
"Homologous recombination: Mediators and Regulators" |
| 12:30 pm | Lunch |
| 3:00 - 3:45 pm | Informal, optional presentation - The NIH peer review process and
grantsmanship -- Victor Fung (SRA, Chemical Pathology Study Section), and Richard Pelroy (Program Director) |
| 4:00 - 5:30 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | RECOMBINATION & DSB REPAIR |
| 7:30 - 8:00 pm | Ed Egelman, University of Virginia Health Sciences Center
"Structure/Function relationships in protein-DNA complexes active in DNA recombination, replication and repair" |
| 8:00 - 8:30 pm | Shunichi Takeda, Kyoto University
"Functional interactions between homologous DNA recombination and translesion DNA synthesis in postreplicational repair" |
| 8:30 - 9:00 pm | Roland Kanaar, Erasmus University
"Mechanisms of mammalian DNA double-strand break repair" |
| 9:00 - 9:30 pm | John Tainer, Scripps Research Institute
Discussion Leader
"Recombination and double-strand break repair: Unifying molecular structures with biology" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | REGULATION AND SIGNALING IN DNA REPAIR |
| 9:00 -9:30 am | Thomas Begley, Massachusetts Institute of Technology
"Complex responses to damaging agents" |
| 9:30 - 10:00 am | Daniel Figeys, MDS-Proteomics
"Application of proteomics to drug discovery" |
| 10:00 - 10:30 am | Coffee break |
| 10:30 - 11:00 am | Paul Russell, The Scripps Research Institute
"DNA damage response mechanisms: Lessons from fission yeast" |
| 11:00 - 11:40 am | Late-breaking developments from poster session |
| 11:40 - 12:20 pm | Phil Hanawalt, Stanford University
Discussion Leader |
| 12:30 pm | Lunch |
| 4:00 - 5:15 pm | Poster session II, continued |
| 5:15 - 6:00 pm | Business meeting for all participants |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CONTROL OF ACCESS TO CHROMATIN |
| 7:30 - 8:00 pm | Genevieve Almouzni, Institut Curie
"From nucleosome to heterochromatin: formation and maintenance in the context of the cell cycle and DNA damage" |
| 8:00 - 8:30 pm | Andre Nussenzweig, National Institutes of Health
"DNA damage detection and repair: roles in lymphocyte development and genome stability" |
| 8:30 - 9:00 pm | Steve Jackson, Wellcome/CRC Institute
"Early events in the DNA damage response" |
| 9:00 - 9:30 pm | Michael Smerdon, Washington State University
Discussion Leader |
| 9:30 - 11:30 pm | Closing social gathering, Geoff Stradling quartet in Lobby Bar |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
