| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | KEYNOTE PRESENTATIONS |
| 7:30 pm - 8:30 pm | Stephen Elledge (Harvard)
"Sensing and Responding to DNA Damage" |
| 8:30 pm - 9:30 pm | Eugene Koonin (NIH)
"Origin and Evolution of Eukaryotic DNA Repair" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | WHAT'S NEW IN EXCISION REPAIR I |
| Chair: Richard Wood (Univ. of Pittsburgh) |
| 9:00 am - 9:40 am | James Ford (Stanford)
"Regulation of Human Nucleotide Excision Repair
by the p53 Tumor Suppressor Gene" |
| 9:40 am - 10:20 am | Hans Krokan (Norwegian Univ. of Science and Tech.)
"Base Excision Repair of Damaged DNA in Preformed
Subsets of Repairosomes" |
| 10:20 am - 10:40 am | Coffee Break |
| 10:40 am - 11:20 am | Simon Reed (Univ. of Wales)
"An ECS Type Ubiquitin Ligase Regulates UV Radiation Survival
Independently of Proteolysis"
|
| 11:20 am - 12:00 pm | Stuart Clarkson (Univ. of Geneva)
"XPG Protein and Apoptosis" |
| 12:10 pm - 12:30 pm | Richard Wood (Univ of Pittsburgh)
Discussion Leader |
| 12:30 pm | Photo / Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | WHAT'S NEW IN EXCISION REPAIR II |
| Chair: Tomas Lindahl (Cancer UK) |
| 7:30 pm - 8:00 pm | Laura Niedernhofer (Univ. of Pittsburgh)
"Crosslinks, Cancer and Aging" |
| 8:00 pm - 8:30 pm | Sankar Mitra (UT Galveston)
"Subpathways in Repair of Oxidized Bases in
Mammalian Genomes" |
| 8:30 pm - 9:00 pm | Richard Cunningham (SUNY)
"Exclusion of Non-Canonical Purines from DNA" |
| 9:00 pm - 9:30 pm | Tomas Lindahl (Cancer UK)
Discussion Leader |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | STRAND BREAK REPAIR I |
| Chair: Steve West (Cancer UK) |
| 9:00 am - 9:40 am | Alan D'Andrea (Dana Farber Cancer Ctr.)
"The Fanconi Anemia/BRCA Pathway in the Damage Response" |
| 9:40 am - 10:20 am | Simon Boulton (Univ. of London)
"Elucidating the Function of BRCA2 in C. elegans" |
| 10:20 am - 10:40 am | Coffee Break |
| 10:40 am - 11:20 am | Yilun Liu (Cancer UK)
"Holliday Junction Processing in Mammalian Cells" |
| 11:20 am - 12:00 pm | Martin Brown (Stanford)
"Genomic Approaches in Yeast to Discover New Genes
Involved in DNA Repair and Genomic Instability" |
| 12:00 pm - 12:30 pm | Steve West (Cancer UK)
Discussion Leader |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | STRAND BREAK REPAIR II |
| Chair: Rodney Rothstein (Columbia) |
| 7:30 pm - 8:00 pm | Sunichi Takeda (Kyoto Univ.)
"A Direct Role For TLS Polymerases in Homologous Recombination" |
| 8:00 pm - 8:30 pm | John Petrini (Memorial Sloan-Kettering)
"Genetic Analysis of the DNA Damage Response" |
| 8:30 pm - 9:00 pm | Christine Richardson (Columbia)
"DNA Recombination and Repair Pathways in Differentiated Cell Lineages" |
| 9:00 pm - 9:30 pm | Rodney Rothstein (Columbia)
Discussion Leader |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DNA DAMAGE AND REPAIR IN IMMUNE MECHANISMS |
| Chair: Michael Neuberger (Kings College) |
| 9:00 am - 9:40 am | Myron Goodman (USC)
"Mutational Specificity and Mechanism of AID, Mutant AID and a Cohort Apobec3G DNA Deaminase" |
| 9:40 am - 10:20 am | Fred Alt (Harvard)
"AID Modifications and Cofactors Direct Deamination Activity to Somatic Hypermutation" |
| 10:20 am - 10:40 am | Coffee Break |
| 10:40 am - 11:20 am | Michael Lieber (USC)
"Non-B DNA Structures at Physiologic and Pathologic Chromosomal Break Sites" |
| 11:20 am - 12:00 pm | Ned Landau (Salk Institute)
"HIV Vif: Defeating Innate Immunity" |
| 12:00 pm - 12:30 pm | Michael Neuberger (Kings College)
Discussion Leader |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | TELOMERES AND DNA DAMAGE RESPONSES |
| Chair: Elizabeth Blackburn (UCSF) |
| 7:30 pm - 8:00 pm | Tom Petes (Univ. of North Carolina)
"Chromosome Fragile Sites in Yeast" |
| 8:00 pm - 8:30 pm | TBA |
| 8:30 pm - 9:00 pm | M. Stephen Meyn (University of Toronto) |
| 9:00 pm - 9:30 pm | Elizabeth Blackburn (UCSF)
Discussion Leader |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DNA DAMAGE CHECKPOINT RESPONSES |
| Chair: Tony Carr (Univ. of Sussex) |
| 9:00 am - 9:40 am | Yossi Shiloh (Tel Aviv Univ.)
"Ataxia-Telangiectasia: Further Expansion of the ATM-Mediated Damage Response" |
| 9:40 am - 10:20 am | Michael Kastan (St. Jude)
"Signaling to and from ATM after DNA Damage" |
| 10:20 am - 10:40 am | Coffee Break |
| 10:40 am - 11:20 am | John Diffley (Cancer UK)
"Regulation of DNA Replication During the Cell Cycle and in Response to DNA Damage" |
| 11:20 am - 12:00 pm | David Lydall (Univ. of Manchester)
"Telomeres, Nucleases and Checkpoint Pathways in Budding Yeast" |
| 12:00 pm - 12:30 pm | Tony Carr (Univ. of Sussex)
Discussion Leader |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | PROTEIN MODIFICATIONS IN BIOLOGICAL RESPONSES TO DNA DAMAGE |
| Chair: Alan Lehmann (Univ. of Sussex) |
| 7:30 pm - 7:55 pm | Jesper Svejstrup (Cancer UK)
"Contending with RNA Polymerase Stalled at DNA Damage" |
| 7:55 pm - 8:20 pm | Primo Scharr (Univ. of Basel)
"Regulatory Protein-Modifications in Mammalian
Base Excision Repair" |
| 8:20 pm - 8:45 pm | Stephan Jentsch (Max Planck Inst.)
“Role of Ubiquitin and SUMO in DNA Repair" |
| 8:45 pm - 9:10 pm | Yoshihiro Nakatani (Harvard)
"Signal Transduction Mechanisms Induced
by UV-Damaged DNA" |
| 9:10 pm - 9:30 pm | Alan Lehmann (Univ. of Sussex)
Discussion Leader |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
