Genome Maintenance: From Molecules and Mechanisms to Humans and Therapies

Exposures to environmental and endogenous DNA damaging agents produce thousands to over a million DNA lesions and chemical modifications to the genome per cell every day. Perturbations in the cellular pathways that respond to DNA damage are linked to myriad human diseases across nearly every cell and organ type. Conversely, dysfunction in DNA damage responses presents new vulnerabilities that are being leveraged to selectively target tumors in a more efficacious and less toxic manner. This GRC will bring together researchers at all levels including principal investigators, lead scientists, postdoctoral fellows and graduate students from academia, government and industry, to share and discuss the latest cutting-edge research on mechanisms of genome maintenance and roles in human health.

A diverse group of invited speakers will present new ideas, approaches, and discoveries at the forefront of DNA mammalian repair research. Additionally, several talks will be selected from the abstract submissions, and highly interactive poster sessions will provide opportunities for sharing and discussing research. This GRC will continue a strong tradition of inclusivity by welcoming young scientists, women, and underrepresented members of the scientific community in a format that engages all participants in discussion through an open and interactive atmosphere of scientific exchange.

Applications from scientists interested in all aspects of DNA metabolism and genome maintenance from fundamental mechanisms to clinical interventions are encouraged to apply. Trainees are encouraged to attend this GRC and the associated GRS.