| SATURDAY |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | DNA Repair and Cancer Biology |
| Discussion Leader: Christiane Kuschal (NIH) |
| 3:45 pm - 4:05 pm | Carolina Quayle (University of São Paulo, Brazil)
"CPD removal induces skin pigmentation and prevents local deleterious effects induced by UVB skin irradiation of DNA repair-deficient XPA mice"
|
| 4:05 pm - 4:10 pm | Discussion |
| 4:10 pm - 4:25 pm | Shivam Mukherjee (Stony Brook University)
"Synthesis of Nitrogen Mustard DNA Interstrand Crosslink Analogs for Structural and Biological Studies" |
| 4:25 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Intersection Between Repair and DNA Damage Signaling |
| Discussion Leader: Gargi Ghosal (MD Anderson Cancer Center) |
| 7:30 pm - 7:50 pm | Frank Couch (Vanderbilt School of Medicine)
"ATR phosphorylates SMARCAL1 during replication stress to prevent aberrant fork processing"
|
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Rajashree Deshpande (University of Texas at Austin)
"Mre11-Rad50 regulates DNA tethering, end resection and ATM checkpoint signaling through ATP-driven Rad50 conformational changes"
|
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Meilen Munoz (Beckman Research Institute of City of Hope)
"RNF168 is important for defects in homologous recombination caused by loss of BRCA1"
|
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Valentyn Oksenych (Harvard Medical School)
"DNA-dependent protein kinase catalytic subunit is required for Signal End Joining during V(D)J recombination, in the absence of DNA Repair factor XLF"
|
| 9:20 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 10:00 am | DNA Repair in the Context of Chromatin |
| Discussion Leader: Dong Wang (University of California San Diego) |
| 9:00 am - 9:20 am | Pierre-Alexandre Vidi (Purdue University)
"The Nuclear Mitotic Apparatus Protein (NuMA) is essential for the accumulation of the ISWI ATPase SNF2h at DNA breaks"
|
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Francois Aymard (LBCMCP-CNRS)
"Transcription channels DNA double strand breaks to a RAD51-dependent repair pathway"
|
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 11:00 am | Recombination and Genome Stability |
| Discussion Leader: Himjyot Jaiswal (Karolinska Institute) |
| 10:00 am - 10:20 am | Hui Zhang (Emory University)
"SIRT2 Directs the Replication Stress Response by Activating CDK9 Through Deacetylation"
|
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Jessica Williams (NIEHS/NIH)
"Topoisomerase 1-mediated Removal of Ribonucleotides from Nascent Leading Strand DNA"
|
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Mentorship Session: Career Panel |
| Discussion, Question and Answer Session featuring Tanya Paull (University of Texas at Austin),
Wei Yang (NIH), Markus Lobrich (Technical University Darmstadt) and Mark O'Connor (AstraZeneca) |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
| 3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
