| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session: A Historical Perspective |
| Discussion Leader: Julie Rageul (Stony Brook University, USA) |
| 3:45 pm - 4:20 pm | Philip Hanawalt (Stanford University, USA)
"From Pyrimidine Dimers to R-Loops in 50 Years" |
| 4:20 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Shedding Lights on Early Events in DNA Repair / Tackling Problems that DNA Repair Might Leave Behind |
| Discussion Leaders: Bret Freudenthal (NIEHS/NIH, USA), Abigail Lubin (University of Miami Miller School of Medicine, USA) and Lan Wang (Harvard University, USA) |
| 7:30 pm - 7:50 pm | Poonam Agarwal (University of Texas, Austin, USA)
"Nucleosome Acidic Patch Promotes RNF168 and BMI1/RING1B Dependent H2A/X Ubiquitination and DNA Damage Signaling" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Muwen Kong (University of Pittsburgh, USA)
"Single-Molecule Studies of Rad4 on Defined DNA Substrates Reveal a Two-Step Damage Recognition Process" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Melike Caglayan (National Institute of Environmental Health Science, USA)
"Role of pol β in Complementing Aprataxin Deficiency During Abasic-Site Base Excision Repair" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Salomé Adam (Epigenetics and Cell Fate Center, France)
"New Insights into Epigenome Maintenance in Response to DNA Damage by Real-Time Tracking of Histone Dynamics in Human Cells" |
| 9:20 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Molding DNA: Single-Stranded DNA Binding Proteins at the Helm / Keeping Homology-Directed Repair Under Control |
| Discussion Leaders: Semsi Derkunt (Stony Brook University, USA) and Molly Hardebeck (University of Texas Southwestern Medical Center, USA) |
| 9:00 am - 9:20 am | Kamakoti Bhat (Vanderbilt University, USA)
"High Affinity Binding of Replication Protein A (RPA) to DNA Directs SMARCAL1 Dependent Replication Fork Remodeling" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Logan Myler (University of Texas, Austin, USA)
"Single-Molecule Imaging Reveals the Mechanism of Exo1 Regulation by Single-Stranded DNA Binding Proteins" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Elaina Maginn (Imperial College London, United Kingdom)
"DNA-PKcs and Regulators of Ubiquitinylation Are Key Therapeutic Targets for Chemotherapy Resistant Ovarian and Pancreatic Cancers, and Modulate Activity of the Homologous Repair Pathway" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Elizabeth Kass (Memorial Sloan-Kettering Cancer Center, USA)
"Effect of Genetic and Developmental Changes on Homology-Directed Repair in the Mouse Mammary Gland" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Mentorship Component: Career Panel |
| Discussion Leaders: Carrie Margulies (Massachusetts Institute of Technology, USA) and Kareem Mohni (Vanderbilt University School of Medicine, USA) |
| 1:30 pm - 2:30 pm | Panel Discussion |
| "Shaping Your Next Move" |
|
- Karlene Cimprich (Stanford University School of Medicine, USA)
- Paula Fischhaber (California State University Northridge, USA)
- Jill Fuss (Lawrence Berkeley National Laboratory, USA)
- Mark O'Connor (AstraZeneca, United Kingdom)
- Brian Plosky (Molecular Cell, USA)
|
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
