Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Stem Cells and Reproductive Diseases
Discussion Leader: Jon Oatley (Washington State University, USA)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:15 pm
Amander Clark (University of California, Los Angeles, USA)
"Using Human Pluripotent Stem Cells to Model Germline Development"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Barbara Vanderhyden (University of Ottawa, Canada)
"Stem Cells and the Origins of Ovarian Cancer"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Mana Parast (University of California, San Diego, USA)
"Modeling Human Placental Development and Disease Using Pluripotent Stem Cells"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Making Golden Eggs and Embryos
Discussion Leader: Richard Anderson (University of Edinburgh, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Nicolas Plachta (Institute of Molecular and Cell Biology, A*STAR, Singapore)
"Imaging the Mechanisms and Forces that Form the Early Mouse Embryo"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Irina Larina (Baylor College of Medicine, USA)
"In Vivo Imaging of Mouse Reproductive Processes"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Lei Lei (University of Michigan, USA)
"Role of Fetal Germ Cell Connectivity in Oocyte Developmental Potential"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
Klementina Fon Tacer (St. Jude Children's Research Hospital, USA)
"MAGE-A Cancer Testis Antigens Protect Mammalian Male Germ Cell Against Environmental Stress"
11:20 am - 11:25 am
Discussion
11:25 am - 11:50 am
Richard Freiman (Brown University, USA)
"Regulating Early Oocyte Development and How a Pinch of TAF4b Goes a Long Way"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Shiying Jin (University of Michigan, USA)
"Bipotent Stem Cells Support Cyclical Regeneration of Mouse Endometrial Epithelium"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Margaret Petroff (Michigan State University, USA)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Domestic Animal Models for Reproductive Research
Discussion Leader: Fuller Bazer (Texas A&M University, USA)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Bruce Whitelaw (University of Edinburgh, United Kingdom)
"Applying New Breeding Technologies to Livestock"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Eric Pailhoux (INRA, France)
"Contributions of Farm Mammalian Models to the Understanding of Sex Determination and Gonadal Differentiation"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:40 pm
Gregory Johnson (Texas A&M University, USA)
"Cellular Events that Impact the Establishment of Pregnancy in Pigs and Sheep"
7:40 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Making Golden Sperm
Discussion Leader: Melissa Pepling (Syracuse University, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Paula Cohen (Cornell University, USA)
"The Goldilocks Principle: How to Ensure Just the Right Amount of Crossing over in Mammalian Meiosis"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Sima Stroganov (Weizmann Institute of Science, Israel)
"Maternal Hyaluronan Production Is Required for Maintenance of the Avascular Embryonic Niche"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Tony De Falco (Cincinnati Children's Hospital Medical Center, USA)
"Vascular and Immune Regulation of Spermatogenesis"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
Andrea Mietens (Institute of Anatomy and Cell Biology, University of Giessen, Germany)
"Superimposed, but Distinctive Contraction Patterns in Seminiferous Tubules: Different Functions?"
11:20 am - 11:25 am
Discussion
11:25 am - 11:50 am
Tessa Lord (Washington State University, USA)
"Identifying Novel Transcription Factors that Regulate Spermatogonial Stem Cell Function Using a Large Scale siRNA Screen"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Marie Christou-Kent (Université Grenoble Alpes, France)
"PATL2: A Key Actor of Oocyte Maturation Whose Inactivation Causes Infertility in Women and Mice"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cross-Talk at the Maternal-Fetal Interface
Discussion Leader: James Pru (Washington State University, USA)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Carlos Simon (University of Valencia / Igenomix SL, Spain)
"Reproductive and Obstetrical Outcome of miR-30d Deficiency at the Maternal-Embryonic Interface"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Hongmei Wang (Institute of Zoology, Chinese Academy of Sciences, China)
"Syncytiotrophoblast of the Human Placenta and the Pregnancy Outcome"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:40 pm
Indrani Bagchi (University of Illinois at Urbana-Champaign, USA)
"Molecular Basis of Hypoxia Adaptation in Early Pregnancy"
7:40 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Reproduction on Steroids
Discussion Leader: Julie Kim (Northwestern University, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Lee Smith (University of Newcastle, Australia)
"Androgenic Support of Male Fertility and Health: A Done-Deal or Just the Tip of the Iceberg?"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Miguel Angel Brieno-Enriquez (Cornell University, USA)
"Co-Existence of Cells with Pluripotency and Meiotic Cells in Postnatal Naked Mole Rat Ovaries"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Francesco DeMayo (National Institute of Environmental Health Sciences, NIH, USA)
"Progesterone Receptor Regulation of Implantation and Pregnancy"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
Nathan Law (Washington State University, USA)
"Establishment of the Foundational Spermatogonial Stem Cell Pool: Plateaus, Nests and Origins of the Lineage"
11:20 am - 11:25 am
Discussion
11:25 am - 11:50 am
Jeffrey Pollard (University of Edinburgh, United Kingdom)
"Kruppel-Like Transcription Factors as Downstream Modulators of Female Sex Steroid Hormone Action in the Uterus"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Shannon Whirledge (Yale School of Medicine, USA)
"Novel Pathways to IUGR Development: Glucocorticoid Signaling at the Maternal-Fetal Interface"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Fate Determination of Reproductive Cell Lineages
Discussion Leader: Joan Jorgensen (University of Wisconsin-Madison, USA)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Josephine Bowles (The University of Queensland, Australia)
"Sexual Fate Decisions in Mouse Fetal Germ Cells"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Marie-Christine Chaboissier (Institut de Biologie Valrose (iBV) / Universite de Sophia Antipolis, France)
"Differentiation of Somatic Populations in Embryonic Mouse Development: A R-Spondin1 Centric View"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:40 pm
Takashi Shinohara (Kyoto University, Japan)
"Tight Junction and the Fate of Transplanted Spermatogonial Stem Cells"
7:40 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Extrinsic/Intrinsic Influences on Reproductive Processes
Discussion Leader: Wipawee Winuthayanon (Washington State University, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Anne Goriely (University of Oxford, United Kingdom)
"Assessing the Landscape of Selfish De Novo Mutations in Human Testis"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Matteo Avella (University of Tulsa, USA)
"Genome-Edited Mouse Lines Define Mechanisms of Gamete Recognition and Provide Tools for Selection of Human Sperm for Assisted Reproductive Technologies"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Tracy Bale (University of Maryland School of Medicine, USA)
"Novel Role of Epididymal Extracellular Vesicles in Signaling Paternal Stress"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
Elizabeth Bromfield (University of Newcastle, Australia)
"Differential Cell Death Decisions in the Testis: Evidence for an Exclusive Window of Ferroptosis in Round Spermatids"
11:20 am - 11:25 am
Discussion
11:25 am - 11:50 am
Yang Xia (McGovern Medical School, University of Texas Health Science Center at Houston, USA)
"Autoimmunity, Preeclampsia and Inherited Transgenerational Epigenetics"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Katherine Halloran (Texas A&M University, USA)
"Effects of Exogenous Progesterone Administered to Ewes During the Preimplantation Period of Pregnancy on Fetal and Placental Growth in Late Gestation"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Milestones in Reproductive Biology
Discussion Leaders: Margaret Petroff (Michigan State University, USA) and Kyle Orwig (University of Pittsburgh, USA)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:40 pm
Fuller Bazer (Texas A&M University, USA)
"Interferon Tau: Effects Downstream Effects of Pregnancy Recognition Signaling on Conceptus Development"
6:40 pm - 6:50 pm
Discussion
6:50 pm - 7:00 pm
Introduction by Discussion Leader
7:00 pm - 7:30 pm
John McCarrey (University of Texas at San Antonio, USA)
"On the Origin of Spermatogonial Stem Cells: The Golden Boy Hypothesis"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
General Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure