Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Building Blocks for Reproduction: Eggs, Sperm and Uterus
Discussion Leader: Julie Kim (Northwestern University, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Francesca Duncan (Northwestern University, United States)
"Female Reproductive Aging: Perspectives from the Gamete and Beyond"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Stefan Schlatt (University of Münster, Germany)
"Form Follows Function: Anatomical, Functional and Regulatory Duality in the Male Gonad"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Thomas Spencer (University of Missouri, United States)
"Ode to Uterine Glands: Insights into Development and Function from Animal Models to Organoids"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stem Cells in Reproductive Processes
Discussion Leader: Robin Hobbs (Hudson Institute of Medical Research, Australia)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Ina Dobrinski (University of Calgary, Canada)
"Postnatal Maturation of Spermatogonial Stem Cells and their Niche"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Haiqi Chen (UT Southwestern Medical Center, United States)
"Spatial Transcriptomics Reveals Organizing Principles of the Spermatogonial Stem Cell Niche"
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:40 am
Sarah Munyoki (Magee-Womens Research Institute, University of Pittsburgh School of Medicine, United States)
"Putative Human Spermatogonial Stem Cells are Molecularly Heterogeneous with Distinctive Functional Potential"
10:40 am - 10:45 am
Discussion
10:45 am - 11:10 am
Francesca Soncin (University of California, San Diego, United States)
"Investigating Early Placenta Development with Stem Cells"
11:10 am - 11:20 am
Discussion
11:20 am - 11:30 am
Sehee Choi (University of Missouri, United States)
"Preeclampsia Modeling by Using Trophoblast Stem Cells Derived From Umbilical Cords of Affected Infants"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Ciro Amato (National Institute of Environmental Health Sciences, United States)
"A Novel Cell Population From Hindlimbs Interacts with Mesenchymal Cells in the External Genitalia to Facilitate Proper Penis Formation"
11:45 am - 11:50 am
Discussion
11:50 am - 11:55 am
General Discussion
11:55 am - 12:20 pm
Ariella Shikanov (University of Michigan, United States)
"Engineered Biomimetics to Promote Folliculogenesis In Vitro and In Vivo "
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Mellissa Mann (Magee-Womens Research Institute, University of Pittsburgh, United States) and Francesca Soncin (University of California, San Diego, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Developmental Biology and Sex Determination
Discussion Leader: Lane Christenson (University of Kansas Medical Center, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Fei Zhao (University of Wisconsin-Madison, United States)
"Novel Insights into Sexual Differentiation of Reproductive Tracts: Testicular Hormones and Beyond"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Diana Laird (University of California, San Francisco, United States)
"Linking Heterogeneity in Fetal Development to Oocyte Fate and Fitness"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
James Turner (The Francis Crick Institute, United Kingdom)
"Using CRISPR-Cas9 Technology to Generate Single-Sex Mouse Litters"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Internal and External Influences on Reproduction
Discussion Leader: Miguel Brieño-Enriquez (University of Pittsburgh, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Helen Jones (University Florida, United States)
"Manipulating and Understanding the Maternal-Fetal Interface: From Nanoparticles to Multiomics"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Sean Limesand (The University of Arizona, United States)
"Perinatal Development of Glucose Intolerance through Tissue-Specific Programming"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Léa Chicoisne (Institut Cochin, Université de Paris Cité, France)
"Single-Nucleus Atlas of the Choriodecidual Interface Identified Fetal Fibroblasts as the Main Driver of Labor Inflammation"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Ans Van Pelt (University of Amsterdam, The Netherlands)
"Spermatogonial Stem Cells"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Sherman Silber (Sherman Silber MD, United States)
"Robust In Vitro Maturation of Oocytes from Ovarian Tissue, Using Principles of In Vitro Gametogenesis"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Jennifer McKey (Duke university medical center, United States)
"Investigating the Relationship Between Morphogenesis and Functional Differentiation of the Mammalian Ovary"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Bioengineering for Improving Reproductive Outcomes
Discussion Leader: Monica Laronda (Northwestern University, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Kathleen O'Neill (University of Pennsylvania, United States)
"Uterus Transplant: Innovation in Clinical Care and Research"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Jon Oatley (Washington State University, United States)
"Discovery of Evolutionarily Conserved Core Regulators of Spermatogenesis using Multispecies Transcriptomics and Genome Engineering"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 8:55 pm
General Discussion
8:55 pm - 9:20 pm
Katsuhiko Hayashi (Osaka University, Japan)
"Reconstitution of Gametogenesis using Pluripotent Stem Cells"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immune Function in Reproductive Biology
Discussion Leader: Tony De Falco (Cincinnati Children's Hospital Medical Center, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Jannette Dufour (Texas Tech University Health Sciences Center, United States)
"The Sertoli Cell Immune Microenvironment"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Maria Battistone (Massachusetts General Hospital / Harvard Medical School, United States)
"Defending the Epididymal Mucosa: Role of Proton-Secreting Cells and Mononuclear Phagocytes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Xiaowei Gu (Cincinnati Children's Hospital Medical Center, United States)
"Testicular Macrophages are Recruited During a Narrow Fetal Time Window and Promote Organ-Specific Developmental Functions"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Dorothy Sojka (Loyola University Chicago, Stritch School of Medicine, United States)
"Origin of Uterine Tissue-Resident Natural Killer Cells"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
LUAN VU (LSU-PBRC, United States)
"IL10 Appears to Suppress Protective Immune Responses to SARS-CoV-2 During Pregnancy"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Elizabeth Ann Enninga (Mayo Clinic, United States)
"Parturition and innate immune cell activation by fetal DNA"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Reproduction in the Age of Omics
Discussion Leaders: Brian Hermann (University of Texas at San Antonio, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Pat Lonergan (University College Dublin, Ireland)
"Omics Down on the Farm: Insights into Paternal and Maternal Factors Affecting Pregnancy Establishment in Cattle"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Roser Vento-Tormo (Wellcome Sanger Institute, United Kingdom)
"Mapping the Human Female Reproductive Tissue One Cell at a Time"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Miles Wilkinson (University of California, San Diego, United States)
"Tripartite Role for a Single Transcription Factor in Germ Cells"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Molecular and Genetic Control of Reproduction
Discussion Leader: Sue Hammoud (University of Michigan, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Sarah England (Washington University School of Medicine, United States)
"How Ion Channel Modulation Impacts Pregnancy Outcomes"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Emily McGlade (University of Missouri, United States)
"Progesterone Signaling in Oviductal Epithelial Cells Regulates the Inflammatory Response During Preimplantation Embryo Development"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Nehemiah Alvarez (Eastern Virginia Medical School, United States)
"Mouse Ovarian RNA Modification Landscape during Reproductive Aging"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Chen Chen (Michigan State University, United States)
"The Regulation of Male Fertility by Pachytene piRNAs"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
Ryuki Shimada (Department of Chromosome Biology, IMEG, Kumamoto University, Japan)
"STRA8-Rb Interaction Initiates S Phase Entry and Meiosis in Female Germ Cells"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Kimberly Abt (Brown University, United States)
"Investigating the Role of TAF4b in Regulating the Critical Progression Through Prophase I in XX Embryonic Mouse Oocytes"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Mercedes Carro (Cornell University, United States)
"Role of AGO Proteins in Sex Chromosome Inactivation During Spermatogenesis"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Determinants of Reproductive Outcomes and Disease
Discussion Leaders: Richard Freiman (Brown University, United States) and Joan Jorgensen (University of Wisconsin-Madison, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:20 pm
Mary Ann Handel (The Jackson Laboratory, United States)
"Genetics of Reproduction: What We Know and Don’t Know"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:10 pm
Asgi Fazleabas (Michigan State University, United States)
"NOTCH1 – A Friend for Implantation and a Foe for Endometriosis"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
