7:30 Peggy Neville, Chair: Welcome, Introductory Remarks

7:45 Perspectives on hormonal regulation of mammary growth, development, and neoplasia
Sandra Z. Haslam, Ph.D., Michigan State University

8:20 Perspectives on the biology of breast cancer
Gary Chamness. Ph.D., University of Texas, San Antonio, TX

8:55 Mammary gland development and breast cancer: Insightsftom transgenic and knock-out mouse models
Jeffrey Rosen, Ph.D., Baylor College of Medicine, Houston, TX

9:30 Reception

9:30 PM - 1:00 PM Monday: Put up posters for Poster Session II

9:00 AM Announcements

9:05 Introductory Remarks: Kermit Carraway

9:15 Stromal-epithelial recombination studies using tissues./rom transgenic mice
Gerald Cunha, Ph.D., UCSF

9:55 Use of genetically modified mice to study breast development
Robert Weinberg, M.D., Whitehead Institute, MIT

10:35 Coffee Break

10:50 Estrogen regulation of human breast proliferation: epithelial-epithelial interactions
Elizabeth Anderson, Ph.D., Manchester, England

11:30 Young Investigator's Poster Discussion Session

11:30 Robert B. Clarke, Christie Hospital, Manchester, U.K.
p27^KIP1 expression provides evidence that steroid receptor-positive cells are a non proliferating, differentiated sub-population in normal human mammary epithelium.

11:45 Nicholas J. Kenney, Hampton University, Hampton, VA The location of label-retaining cells in the mammary duct: evidence for aggregate
formation in pulse-labeled ouWowths.

12:00 Lewis A. Chodosh, University of Pennsylvania, Philadelphia, PA 19104
Novel kinases in mammary gland development and carcinogenesis

12:15 Lakshmi Sivaraman, Baylor College of Medicine
Effect of selective ablation of mammary epithelial cells on mammary tumorigenesis

12:30 Lunch

Poster Session 1. 4:00 - 6:00 PM; 9:30 PM to Midnight
Put Posters Up: 9:30 P.M Sunday evening to 1:00 Monday PM
Remove posters by 8:30 AM Tuesday morning

6:00 P.M. Dinner

7:30 Introductory Remarks:

Jan-Ake Gustaffson

7:35 Hormone responsiveness andmammary development in ER-aandER-flknock-out mice.
Ken Korach, M.D./Ph.D. NIEHS, Research Triangle Park, NC

8:10 ER-beta: New excitement
Jan-Ake Gustaffson, M.D. Karolinska Institute, Stockholm

8:45 Estrogen regulation of cell cycle progression
Robert Sutherland, Ph.D., Garvan Institute, Sydney, Australia

9:20 General Discussion

8:30AM - 1:00 PM. Put up posters for Poster Session II

8:30 AM. Group Photo Session

9:00 AM Announcements

9:05 Introductory Remarks- Howard Hosick

9:15 Progesterone signaling in mammary gland development
G. Shyamal , Ph.D., Lawrence Berkeley Laboratories, Berkeley, CA

9:55 Expression andjunction ofprogesterone receptors A and B in normal and malignant lissues
Christine Clarke, Ph.D., University of Sydney, Westmead Hospital, NSW, Australia.

10:35 Coffee Break

10:50 Coactivators in steroid receptor action
Dean P. Edwards, Ph.D., University of Colorado Denver, CO

11:30 Young Investigator's Poster Discussion Session

11:30 Libby Gass Handel, University of Colorado, Denver, CO
Progesterone negatively regulates the fl-casein promoter through a composite progesterone receptor-Stat5 element.

11:45 Carol A. Lange, University of Colorado, Denver, CO
Mitogen activated protein lanase phosphorylation of serine 294 in progesterone receptors targets them for ligand-depending destruction by the 26S proteosome.

12:00 Valerie B. Gouon, Albert Einstein College of Medicine, NY
Roles of CSF- I and macrophages in postnatal mammary gland development

12:15 Elaine Y. Lin, Albert Einstein College of Medicine, NY
The role of CSF- I in breast tumor progression

12:30 Lunch

Poster Session II. 4:00 - 6:00 PM; 9:30 PM to Midnight
Put Posters Up: 8:30 AM to 1:00 PM Tuesday
Remove posters by 8:30 AM Wednesday morning

6:00 P.M. Dinner

7:30 introductory Remarks., Nancy Shaper

7:35 B1-4 galactosyl tranferase: Recruitment of a housekeeping gene from the non-mammalian gene pool for a mammary gland specific function.
Nancy Shaper, Ph. D., Johns Hopkins University, Baltimore

8:10 Cell surface galactosyl transferase facilitates differentiation of the mammary gland
Helen Hathaway, Ph.D., University of New Mexico, Albuquerque, NM-

8:45 Butyrophilin
Ian Mather, Ph.D., University of Maryland,College Park, MD

9:20 General Discussion

8:30 AM - 1:00 PM - put up posters for Poster Session III

9:00 AM Announcements

9:05 introductory Remarks: Floyd Schanbacher

9:15 Role of the mammary fat pad in mammary development
Thomas McFadden, Ph.D. Dairy Science Research Group, Hamilton, NZ

9:55 PTHrP regulates fetal mammary development by modulating mesenchymal cell fate decisions
John Wysolmerski MD, Yale University, New Haven, CN

10:35 Coffee Break

10:50 The role of the irradiated microenvironment in mammary epithelial neoplastic progression
Mary Helen Barcellos-Hoff, Ph.D., Lawrence Berkeley Laboratory, Berkeley, CA

11:30 young investigator's Poster Discussion Session

11:30 Rabih Talhouk, American University of Beirut, Lebanon
Modulation Qfjunctional protein expression andjunction in CID-9 mammary cells by extracellular matrix.

11:45 Caroline M. Alexander, Harvard Medical School
Role of cell surface proteoglycans in mouse mammary tumorigenesis: Studies from transgenic mice.

12:00 Michael T. Lewis, University of California, Santa Cruz
Hedgehog signal transduction in mammary gland development and neoplasia

12:15 Beatrice A. Howard, Toby Robins Breast Cancer Research Center, London, U.K.
The characterization of a mouse mutant that displays abnormal mammary gland development

12.30 Lunch

Poster Session Ill. 4-00 - 6:00 PM; 9:30 PM to Midnight
Put Posters Up: 8:30 AM to 1:00 PM Wednesday
Remove posters by 8:30 AM Thursday morning

4:30 Wednesday - Business Meeting

6:00 P.M. Dinner

7:30 Introductory Remarks: Dale Bauman

7:35 Evolution of lactation
Olav Oftedal, Ph.D., Smithsonian Institute, Washington, D.C.

8:10 Regulation of milkfat synthesis in ruminants
Dale E. Bauman, Ph.D., Cornell University, Ithaca, NY

8:45 Regulation of milk synthesis and secretion in marsupials
Kaylene Simpson. Ph.D., Melbourne, Australia

9:20 General Discussion

8:30 AM - 1:00 PM: Put up posters for Poster Session IV

9:00 AM Announcements

9:05 Introductory Remarks: Karen Plaut

9:15 The EGF family of receptors and ligands in mammary development and neoplasia
David F. Stern, Ph.D., Yale University, New Haven, CT

9:55 Roles for the IGFs and IGF binding proteins in mammary ductal growth
Terri Wood, Ph.D., Penn State University/School of Medicine, Hershey, PA

10:35 Coffee Break

10:50 Role of activinlinhibin B in mammary gland development
Gertraud Robinson, Ph.D., NIDDK, NIH, Bethesda MD

11:30 Young Investigator's Poster Discussion Session

11:30 Susan B. Rasmussen, Laboratory of Tumor Immunology and Biology, NCI, Bethesda
Testing the biological consequences of Int6 truncation

11:45 Christine J. Watson, University of Cambridge, U.K.
Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of STA T3

12:00 Kay-Uve Wagner, NIDDK, Bethesda
Conditional knockout of BRCA I in the mammary gland of transgenic mice

12:15 Christopher J. Ormandy, Gravan Institute, Darlinghurst, Australia
Prolactin controls mammary gland development via direct and indirect mechanisms

12:30 Lunch

Poster Session IV. 4:00 - 6:00 PM; 9:30 PM to Midnight
Put Posters Up: 8:30 AM to 1:00 PM Thursday
Remove posters by 8:30 AM Friday morning

6:00 Dinner

7:30 Announcements and Awards

8:00 Nancy Hynes, Ph.D., Friedrich Miescher Institute, Basel, Switzerland
Signaling proteins in mammary development and cancer