| SUNDAY |
| PROLIFERATION #1 |
| 7:30 |
Introduction to conference |
|
Moderator |
| 7:40 |
C. Kent Osborne, UT Health Science Center, San Antonio, USA |
|
Speakers |
| 8:00 |
BACR-sponsored speaker: Tony Howell, Christie Hospital, Manchester, UK
New antioestrogens and the prevention of breast cancer |
| 8:40 |
Françoise Vignon, U540 INSERM, Molecular & Cellular Endocrinology of Cancers, Montpelier, France
Breast cancer cell proliferation: Interactions between steroid and growth factor pathways |
| 9:20 |
Saraswati Sukumar, Johns Hopkins Oncology Center, Baltimore, USA
Gene expression profiling of breast cancer using SAGE and microarray analysis |
| MONDAY |
| PROLIFERATION #2 |
|
Moderator |
| 9:00 |
Nancy Hynes, Friedrich Miescher Institute, Basel, Switzerland |
|
Speakers |
| 9:20 |
William Muller, MacMaster University, Ontario, Canada
Oncogene-mediated signal transduction in transgenic mouse models of human breast cancer |
| 9:50 |
Heidi Lane, Friedrich Miescher Institute, Basel, Switzerland
ErbB2 potentiates breast tumor proliferation through modulation of p27/Cdk2 complex formation |
| 10:20 |
Coffee break and conference photo |
| 10:50 |
Norbert Prenzel, Max-Planck Institute for Biochemistry, Martinsried, Germany
EGF-R transactivation by G-protein coupled receptors in cancer cells requires MMP activity |
| 11:20 |
Chris Benz, University of California, San Francisco, USA
Emerging strategies that target ErbB2 overexpressing breast tumors |
| 4:00-5:00 |
Poster Session #1 |
| INVOLUTION AND APOPTOSIS |
|
Moderator |
| 5:00 |
Margaret Neville, University of Colorado Health Sciences Center, Denver, USA |
|
Speakers |
| 5:20 |
David Flint, Hannah Research Institute, Ayr, UK
IGFBP-5: an inducer of apoptosis and modulator of tissue remodelling in the mammary gland |
| 6:00 |
Steve Anderson, University of Colorado Health Sciences Center, Denver, USA
Delayed mammary gland involution in transgenic mice expressing activated Akt |
| 6:20 |
Ekaterini Kritikou, Department of Pathology, University of Cambridge, UK
STAT3-dependent and independent death pathways in murine mammary epithelia |
| 6:40 |
Kate Walton, National Institute of Health, Bethesda, MD, USA
Expression and function of bcl-x in mouse mammary gland development: a targeted gene deletion approach |
| 7:00 |
Andrew Gilmore, School of Biological Sciences, University of Manchester, UK
Bcl-2 proteins and adhesion in mammary apoptosis |
| TUESDAY |
| DEVELOPMENT |
|
Moderator |
| 9:00 |
Charles Daniel, University of California, Santa Cruz, USA
The mammary gland as a model for development |
|
Speakers |
| 9:20 |
Clive Dickson, Imperial Cancer Research Fund, London, UK
Requirement for cyclin D1 and FGF signalling in the growth and differentiation of mammary gland |
| 9:50 |
Sandy Gendler, Mayo Clinic, Scottsdale, USA
Characterization of MMTV-Neu induced mammary tumors in Muc-1 deficient mice |
| 10:20 |
Coffee break |
| 10:40 |
Laki Buluwela, Imperial College, London, UK
Gene profiling of in vitro HGF/SF stimulated mammary tubule morphogenesis |
| 11:10 |
Sandra Grimm, Baylor College of Medicine Houston, Texas, USA
C/EBP Beta controls cell fate determination during mammary gland development |
| 11:40 |
Alan Clarke, School of Biosciences, University of Cardiff, UK
APC is essential for normal mammary gland function |
| 12:10 |
Gary Silberstein, University of California, Santa Cruz, USA
Pax2 misexpression in breast cancer and the regulation of apoptosis-related genes in Pax2-null chimeric mammary glands |
| 4:00-5:00 |
Poster Session #2 |
| SIGNALLING |
|
Moderator |
| 5:00 |
Jeffrey Rosen, Baylor College of Medicine, Houston, USA |
|
Speakers |
| 5:20 |
Lothar Hennighausen, National Institutes of Health, Bethesda, USA
Targeting signaling pathways in the mammary gland: dissecting cell proliferation, survival and death |
| 6:00 |
Wolfgang Doppler, University of Innsbruck, Austria
Modulators of Stat5 Activation |
| 6:40 |
Geoffrey Lindeman Walter and Eliza Hall Institute for Medical Research, Melbourne, Australia
Identification of S1, a Stat5A-interacting protein |
| 7:00 |
ASTA Medica-sponsored speaker: Bernd Groner, Georg Speyer Haus, Frankfurt am Main, Germany
Co-activator and co-repressor association add versatility to Stat5 functions |
| WEDNESDAY |
| STEM CELLS |
|
Moderator |
| 9:00 |
Daniel Medina, Baylor College of Medicine, Houston, USA |
|
Speakers |
| 9:20 |
Denise Galloway, Fred Hutchinson Cancer Research, Seattle, USA
Immortalization of human mammary epithelial cells |
| 9:50 |
Gilbert Smith, National Cancer Institute, Bethesda, USA
Mammary epithelial stem cells: aging, renewal, neoplasia; a challenge for the millennium |
| 10:20 |
Coffee break |
| ADHESION |
|
Moderator |
| 10:40 |
Jean Paul Thiery Institute Curie, Paris, France
Adhesion and signaling events in the differentiation of the mammary epithelium |
|
Speakers |
| 11:00 |
Walter Birchmeier Max-Delbruck-Centre for Molecular Medicine, Germany
Role of beta-catenin/armadillo in cell adhesion and signal transduction |
| 11:30 |
Jackie Papkoff, Aventis Cambridge Genomics Center, Cambridge, USA
A genomic approach for identification of therapeutic targets in the beta-catenin signal transduction pathway |
| 12:00 |
Lukas Huber , Institute for Molecular Pathology, Vienna, Austria
Molecular organization of CD44 in lipid rafts: involvement in directed lammellipodia outgrowth |
| 4:00-5:00 |
Poster Session #3 |
| DNA REPAIR |
|
Moderator |
| 5:00 |
Chris Benz, University of California, San Francisco, USA |
|
Speakers |
| 5:20 |
Eva Lee, UT Health Science Center, San Antonio, USA
Genes in the DNA damage response and their involvement in cancer: From ATM/ATR and NBS1/Mre11/Rad50 to p53 |
| 6:00 |
Paul Edwards, Department of Pathology, University of Cambridge, UK
Chromosome translocations and karyotypes of breast cancers: a clue to mechanisms of chromosome instability? |
| 6:20 |
Frank Rauscher III, Wistar Institute, Philadelphia, USA
The role of BRCA-1 binding proteins in regulating transcription-coupled DNA repair processes |
| 7:00 |
David Livingston, Dana Farber Cancer Institute, Boston, USA
Functional Analysis of BRCA-1 and BRCA-2 |
| THURSDAY |
| METASTASIS |
|
Moderator |
| 9:00 |
Adrian Harris, Imperial Cancer Research Fund, Oxford, UK
Metastasis in the next decade - integration of molecular mechanisms with therapy |
|
Speakers |
| 9:20 |
Ian Hart, Imperial Cancer Research Fund, St. Thomas' Medical School, London, UK
The microtuble-binding protein RHAMM/IHABP in mammary carcinoma; a role in invasive behaviour? |
| 9:50 |
Arthur Mercurio, Harvard Medical School, Boston, USA
Mechanisms of breast carcinoma invasion and survival |
| 10:20 |
Coffee break |
| 10:40 |
Lief Lund, Finsen Laboratory, Copenhagen, Denmark
Plasminogen activation and tissue remodeling during mammary gland involution and breast cancer |
| 11:10 |
Lynn Matrisian, Vanderbilt University, Nashville, USA
The matrix metalloproteinase matrilysin in mammary tumor progression |
| KEYNOTE ADDRESS |
|
Moderator |
| 7:00 |
Charles Streuli, School of Biological Sciences, University of Manchester, UK |
|
Speaker |
| 7:10 |
Mina Bissell, Lawrence Berkeley National Laboratory, USA
The "wisdom of the matrix" and the structural basis of tissue specificity |
