| SUNDAY, JUNE 3 |
| 2:00-9:00 PM | Arrival and Registration |
| | Sunday 2:00 PM - 4:00 PM Monday: Put up posters for Poster Session I |
| SUNDAY EVENING |
| 7:30 | Charles Daniel, Chair. Welcoming remarks. |
| SESSION I | A Panel Discussion On Problems, Perspectives, and Opportunities In
Mammary Gland Biology And Neoplasia |
| Moderator: Mary Helen Barcellos-Hoff, Ph.D. |
| 7:45 | Historical Overview of Mammary Gland Endocrinology:
Barbara Vonderaar, Ph.D. National Institutes of Health |
| 8:20 | Building a Breast Cancer Research Programme
Alan Ashworth, Chester Beatty Laboratories, London |
| 8:55 | New methods for studying human mammary epithelium in vivo
Jerry Cunha, Ph.D. University of California, San Francisco |
| 9:30 | Reception |
| MONDAY MORNING |
| 9:30 AM - 1:00 PM | Put up posters for Poster Session I |
| 7:30-8:30 | Breakfast |
| 8:30 | Photo Session |
| 9:00 | Announcements |
| SESSION 2 | TISSUE INTERACTIONS IN DEVELOPMENT AND CANCER |
| Chair: Terri Wood, Ph.D., Pennsylvania State University College of
Medicine |
| 9:05 | Introduction: Terri Wood |
| 9:20 | Epithelial and stromal TGFbeta signaling in mammary gland development and
tumor formation
Harold L. Moses, M.D., Vanderbilt University Medical Center |
| 10:00 | Adhesion signaling and apoptosis regulation in breast epithelium
Charles Streuli, Ph.D., University of Manchester |
| 10:40 | Photo Session and Coffee Break |
| 11:00 | Migratory cells in the mammary stroma and their effects on epithelial
development
Jeffrey Pollard, Ph.D., Albert Einstein College of Medicine |
| 11:40 | Selected Short Poster Presentations
- 11:40 - Bryony Wiseman, University of California, San Francisco, San Francisco
CA.Matrix Metalloproteinases Regulate Distinct Aspects of Mammary Gland Branching morphogenesis
- 11:55 - Russell Hovey, National Cancer Institute, Bethesday, MD.
Mammary gland development and function requires STAT5b for prolactin-
and growth hormone-regulated processes
- 12:10 - Hema Parmar, University of California, San Francisco, San Francisco, CA
A Novel In Vivo Method for Studying Stromal Effects on Human Mammary Epithelium
|
| 12:30 | Lunch |
| Poster Session I, 4:00-6:00 PM, 9:30 PM to Midnight |
| 6:00 | Dinner |
| MONDAY EVENING |
| SESSION 3 | IGF IN MAMMARY DEVELOPMENT AND CANCER |
| Chair: Richard Di Augustine, Ph.D. NIH, NIEHS |
| 7:30 | Introduction: Richard Di Augustine |
| 7:50 | IGF-I: The Common Denominator in the Hormonal Development of the
MammaryGland
David Kleinberg, M.D., New York University School of Medicine |
| 8:30 | IGF signaling in breast cancer
Doug Yee, M.D., University of Minnesota Cancer Center
|
| 9:10 | General Discussion of the Day's Talks
Moderators Richard DiAugustine and Terri Wood |
| TUESDAY MORNING |
| 8:30AM - 1:PM. | Put up posters for Poster Session II |
| 9:00 AM | Announcements |
| SESSION 4 | CELL IDENTITY, DIFFERENTIATION, AND FUNCTION |
| Chair: Gilbert Smith, Ph.D., NIH, NCI |
| 9:05 | Introduction: Gilbert Smith |
| 9:20 | OPGL links bone loss to mammary gland formation
Josef M. Penninger, M.D., The Amgen Institute, University of Toronto |
| 10:00 | HSIX1: A homeobox gene implicated in cell cycle control and breast cancer
Heide L. Ford, Ph.D., University of Colorado Health Sciences Center |
| 10:40 | Coffee Break |
| 11:00 | Hedgehog signaling in differentiation and function of the mouse mammary gland
Michael Lewis, Ph.D. University of Colorado Health Sciences Center |
| 11:40 | Young Investigators: Selected Short Poster Presentations
- 11:40 - Bryan Welm, Baylor College of Medicine, Houston, TX.
Inducible Activation of Fibroblast Growth Factor Receptors as a Method to Study Mammary Gland Tumorigenesis
- 11:55 - Esther Landesman-Bollag, Boston University School of Medicine, Boston, MA.
Protein Kinase CK2 in Mammary Gland Development and Tumorigenesis
- 12:10 - Cathrin Brisken, Whitehead Institute for Biomedical Research, Cambridge, MA.
From Red Cells to Milk: The Erythropoietin Receptor Intracellular Domain Rescues Prolactin Receptor Function
|
| 12:30 | Lunch |
| Poster Session I (Continued), 4:00-6:00 PM, 9:30 PM to Midnight
|
| 6:00 | Dinner |
| TUESDAY EVENING |
| SESSION 5 | TUMOR PROGRESSION AND METASTASIS |
| Chair: Carlos Arteaga, M.D., Vanderbilt Medical School |
| 7:30 | INTRODUCTION: Carlos Arteaga |
| 7:50 | Role of laminins and matrix metalloproteases in breast cancer
invasion and metastasis
Vito Quaranta, M.D., Scripps Research Institute |
| 8:30 | Inducible transgenic models for mammary carcinogenesis
Lewis Chodosh, M.D., Ph.D., University of Pennsylvania School of Medicine |
| 9:10 | General Discussion of the Day's Talks:
Moderators Carlos Arteaga and Gilbert Smith |
| WEDNESDAY MORNING |
| 7:00 AM - 4:30 PM | Remove Posters for Session I as early as possible. Put up posters for Poster Session II |
| 9:00 AM | Announcements |
| SESSION 6 | THE LACTATION CYCLE |
| Chair: Thomas Keenan, Ph.D., Virginia Tech |
| 9:05 | Introduction: Thomas Keenan |
| 9:20 | Stage II lactogenesis, a profound molecular switch triggered by progesterone withdrawal
Peggy Neville, Ph.D., University of Colorado Health Sciences Center |
| 10:00 | GLUT1 targeting in mammary epithelial cells
Peter Haney, Ph.D., M.D., Baylor College of Medicine |
| 10:40 | Coffee Break |
| 11:00 | Proteomics and the Golgi of the Mammary Epithelial Cell
Kathryn Howell, Ph.D. University of Colorado Health Sciences Center |
| 11:40 | Selected Short Poster Presentations
- 11:40 - Ling Zhao, NIH, Bethesda, MD.
A Role for the IL6 - Stat3 Pathway in Mammary Gland Involution
- 11:55 - Senthil K. Muthuswamy, Harvard Medical School, Boston, MA
ErbB2, But Not ErbB1, Can Disrupt Cell Polarity, Reinitiate Proliferation and Induce Luminal Repopulation in Growth-Arrested Epithelial Acini
- 12:10 - Preeti Ismail, Baylor College of Medicine, Houston, TX
Targeted Insertion of a LacZ Reporter Gene into the Murine or Locus Reveals Complex and Dynamic Expression in the Mammary Gland
|
| 12:30 | Lunch |
| Poster Session II. 4:00 - 6:00PM; 9:30 PM to Midnight
|
| 4:30 | Business Meeting |
| 6:00 | Dinner |
| WEDNESDAY EVENING |
| SESSION 7 | CARCINOGENESIS AND GENOME STABILITY |
| Moderator: Daniel Medina, Ph.D., Baylor College of Medicine |
| 7:30 | Introductory Remarks: Daniel Medina |
| 7:30 | Genetic alterations during mammary tumorigenesis in BALB/c-Trp53+/- mice: A
model for Li-Fraumeni Syndrome
Joseph Jerry , Ph.D., University of Massachusetts |
| 8:10 | Genes activated by MMTV and their effect on mammary gland development and
tumorigenesis
Robert Callahan, Ph.D., NIH, NCI |
| 8:50 | Telomere Dynamics and the Development of TGFbeta Resistance during Transformation of Cultured Human Mammary Epithelial Cells
Paul Yaswen, Ph.D. Lawrence Berkeley National Laboratory |
| THURSDAY MORNING |
| 9:00 | Announcements |
| SESSION 8 | SIGNAL TRANSDUCTION IN DEVELOPMENT AND NEOPLASIA |
| Chair: William Muller, Ph.D., McMaster University |
| 9:05 | Introductory Remarks: William Muller |
| 9:25 | Signal Transduction Pathways Important for Ductal Morphogenesis Studied in Genetically Engineered Mice
Jeffrey Rosen, Ph.D. Baylor College of Medicine |
| 10:00 | Transcriptional regulation of apoptosis andsurvival in mouse mammary gland
Christine Watson, Ph.D., University of Cambridge, UK |
| 10:40 | Coffee Break |
| 11:00 | Genomic and Non-genomic Actions of Prolactin
Charles Clevenger, M.D., Ph.D., University of Pennsylvania |
| 11:40 | Selected Short Poster Presentations
- 11:40 - Lindsay Hinck, University of California, Santa Cruz, Santa Cruz, CA
The Role of an Axonal Guidance Molecule in the Mammary Gland
- 11:55 - Valerie M. Weaver, University of Pennsylvania, Philadelphia, PA
4-Integrin-dependent Formation of Polarized Three-Dimensional Architecture Confers Resistance to Apoptosis in Normal and Malignant Mammary Epithelium
- 12:10 - Kenneth Ewan, E.O. Lawrence Berkeley National Laboratory, Berkeley, CA
Transforming Growth Factor b1 (TGFb1) Modulates Ovarian Steroid hormonal Stimulation of Mammary Epithelium
|
| 12:30 | Lunch |
| Poster Session II (Continued). 2:00 - 6:00 PM, 9:30 PM to Midnight
Remove posters Friday morning |
| 6:00 | Dinner |
| THURSDAY EVENING |
| 7:30 | Announcements and Awards |
| SESSION 9 | KEYNOTE ADDRESS |
| Moderator, Charles Daniel |
| 8:00 | KEYNOTE SPEAKER Daniel Medina, Ph.D. ,Baylor College of Medicine
Biological and molecular aspects of premalignant progression |
| FRIDAY MORNING |
| Breakfast, take down any remaining posters, depart. |
