| SUNDAY |
| 7:30 pm | Introductory Remarks |
| Keynote Speaker
|
| Hans Clevers: University Medical Center Utrecht, Utrecht, The Netherlands
Wnt signalling/Lef1/Tcfs: From flies to mammary glands |
| MONDAY |
| Pre-natal Mammary Gland Development |
| 9:00-9:15 | Moderator: Gertraud Robinson NIDDK, National Institutes of Health, USA |
| 9:15-9:55 | Saverio Bellusci, Institut Curie, Paris, France
"Fgfs in early mammary placode development" |
| 9:55-10:35 | Klaus Kratochwil, Austrian Academy of Sciences, Salzburg, Austria
"Lef1 and epithelial/mesenchymal signaling" |
| 10:35-11:00 | Coffee break |
| 11.00-11:40 | John Wysolmerski, Yale University School of Medicine, Conn., USA
"PTHrP signaling in the mammary gland" |
| 11:40-12:00 | Kenna Mills, Harvard Medical School, Boston, USA.
"Cell death processes associated with lumen formation during mammary acinar morphogenesis. |
| Mammary Stem Cell Biology |
| 5:00-5:15 pm | Moderator: Trevor Dale, Institute for Cancer Research, London, UK |
| 5:15-5:55 | Margaret Goodell, Baylor College of Medicine, Texas, USA.
"Stem cell biology" |
| 5:55-6:35 | Max Wicha, University of Michigan, USA.
"Human mammary stem cells" |
| 6:35-7:15 | Robert Clarke, Christie Hospital Trust, Manchester, UK.
"Human mammary stem cells" |
| 7:15-7:35 | Kay-Uwe Wagner, University of Nebraska Medical Center, Nebraska, USA,
"An adjunct mammary epithelial cell population in parous females" |
| TUESDAY |
| Paracrine Regulators in Mammary Gland Function |
| 9:00-9:15 | Moderator: Lothar Hennighausen, National Institutes of Health, USA |
| 9:15-9:55 | Zena Werb, UCSF, San Francisco, USA
"Tissue proteases and mammary gland branching morphogenesis" |
| 9:55-10:35 | Hartmut Beug, IMP, Vienna, Austria.
"TGF-b and epithelial-mesenchymal transitions" |
| 10:35-11:00 | Coffee break |
| 11.00-11:40 | Andrew Ziemiecki, University of Bern, Switzerland.
"Vascular remodelling in the mammary gland" |
| 11:40-12:00 | Victoria Seewaldt, Duke University, Durham, NC, USA
"CBP modulates resistance to reconstituted extracellular matrix-induced apoptosis in human mammary epitherlial cells" |
| Cell Cycle Regulation in Mammary Gland Development and Breast Cancer |
| 5:00-5:15 | Moderator: Mary Helen Barcellos-Hoff, UC Berkeley, CA, USA. |
| 5:15-5:55 | Carlos Arteaga, Vanderbilt University, Nashville, Tn, USA.
"Role of p27 in mammary gland morphogenesis" |
| 5:55-6:35 | Peter Sicinski, Harvard Medical School, Boston, Mass.,USA.
"Cyclin D1 in mammary gland development and mammary cancer" |
| 6:35-7:15 | Kun Ping Lu, Harvard Medical School, Boston Mass, USA.
"The prolyl isomerase Pin1 in mammary gland development and breast cancer" |
| 7:15-7:35 | Yixue Cao, University of California, La Jolla, USA.
"IKKa provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development" |
| WEDNESDAY |
| Hormone Regulation of Mammary Gland Development |
| 9:00-9:15 | Moderator: Barbara Vonderhaar, National Institutes of Health, USA |
| 9:15-9:55 | Myles Brown, Dana-Farber Cancer Institute, Mass., USA.
"Dynamics of ER Signaling" |
| 9:55-10:35 | Orla Conneely, Baylor College of Medicine, Texas, USA.
"Analysis of PR-a/PR-b function using isoform specific gene knockouts " |
| 10:35-11:00 | Coffee break |
| 11:00-11:20 | Zhiyong Wang, The Salk Institute, La Jolla, USA.
"Roles of transcriptional coactivators in mammary gland development" |
| 11.20-12:00 | Chris Ormandy, Garvan Institute, Darlinghurst, Australia
"Prolactin signaling" |
| Receptor Signaling in Mammary Gland Biology |
| 5:00-5:15 | Moderator: Geoffrey Lindeman, The Walter and Eliza Hall Institute, Melbourne, Australia. |
| 5:15-5:55 | Adrian Lee, Baylor College of Medicine, Houston, TX, USA.
"IGF-1 signalling in mammary gland development and breast cancer. |
| 5:55-6:35 | Nancy Hynes, Friedrich Miescher Institute, Basel, Switzerland.
"ErbB2 signalling and breast cancer" |
| 6:35-6:55 | Christian Dillon, Cancer Research UK, London, UK.
"Basolateral targeting of ErbB2 is dependent on a novel bipartite juxtamembrane sorting signal" |
| 6:55-7:15 | Keiko Miyoshi, The University of Tokushima, Japan.
"Signal transducer and activator of transcription 5 (Stat5) controls the specification and proliferation of mammary alveolar epithelium". |
| 7:15-7:35 | Donald White, McMaster University, Canada.
"Integrin-linked kinase in mammary gland development and tumorigenesis" |
| THURSDAY |
| Breast Cancer: Genes to New Therapies |
| 8:45-9:00 | Moderator: Jeffrey Rosen, Baylor College of Medicine, Houston, TX, USA |
| 9:00-9:40 | Ashok Venkitaraman, The Cambridge Institute for Medical Research, UK.
"BRCA1/2 and DNA repair" |
| 9:40-10:20 | Mitch Dowsett, The Royal Marsden Hospital, London, UK.
"Aromatase inhibitors" |
| 10:20-10:40 | Coffee break |
| 10.40-11:20 | Elizabeth Jaffee, Johns Hopkins University School of Medicine, USA.
"Combinatorial therapies for breast cancer treatment" |
| 11:20-12:00 | Alan Wakeling, AstraZeneca, Manchester UK.
"Receptor kinase inhibitors in breast cancer therapy" |
| 6:15 pm | Introductory Remarks |
| Keynote Speaker |
| Joyce Taylor-Papadimitriou, ICRF Breast Cancer Biology Group, London, UK
Mucins: from cell biology to targeted gene therapy |
