| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Opening Address |
| 7:30 pm - 8:00 pm | Chair's Introduction |
| 8:00 pm - 9:00 pm | Sir David Lane (University of Dundee, UK)
"Controlling p53" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cancer Risk Factors and Therapies |
| 9:00 am - 9:15 am | Moderator : Dan Medina (Baylor College of Medicine, Houston, Texas) |
| 9:15 am - 9:55 am | Steve Hursting (NCI, National Institutes of Health, USA)
"Diet, Energy Balance and Mammary Cancer - Experimental Approaches" |
| 9:55 am - 10:35 am | Elizabeth Anderson (Christie Hospital NHS Trust, Manchester, UK)
"Mechanisms by which pregnancy protects against breast cancer. Of mice and (wo)men" |
| 10:35 am - 10:55 am | Group Photo / Coffee Break |
| 10:55 am - 11:35 am | Adrian Lee (Texas Medical Centre, Houston, USA)
"The growth hormone/IGF-I axis in mammary development and tumorigenesis" |
| 11:35 am - 12:15 pm | Britta Weigelt (Netherlands Cancer Institute, Amsterdam, The Netherlands)
"Predicting breast cancer disease outcome, using the genome as a sensor pad" |
| 12:15 pm - 12:30 pm | Short presentation |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session I |
| 5:30 pm - 7:30 pm | Stem Cells and Cancer |
| 5:30 pm - 5:45 pm | Moderator: Rob Clarke (University of Manchester, UK) |
| 5:45 pm - 6:20 pm | James Sherley (Massachusetts Institute of Technology, Cambridge, Massachusetts, USA)
"A Carpenter's Rule for Genetic Fidelity in Adult Stem Cells" |
| 6:20 pm - 6:55 pm | Gil Smith (National Institutes of Health, USA)
"Long label retention and asymmetric division: Are they related in the
mammary epithelium?" |
| 6:55 pm - 7:10 pm | Natasza Kurpios (McMaster University, Hamilton, Canada)
"Molecular and Functional Characterization of Mammary Epithelial Stem/Progenitor Cells Cultured In Vitro" |
| 7:10 pm - 7:30 pm | Marie Ange Deugnier (UMR144 CNRS-Institut Curie, Paris, France)
"The mouse mammary epithelial cell line, Comma-Dbgeo, contains Sca-1 positive progenitor cells that express a basal non-myoepithelial phenotype" |
| 8:00 pm | Dinner |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Embryonic development |
| |
| 9:00 am - 9:15 am | Moderator : John Wysolmerski (Yale University School of Medicine, New Haven, USA) |
| 9:15 am - 9:55 am | Sarah Miller (University of Pennsylvania, USA)
"Dickkopf 1 overexpression suppresses mammary bud development" |
| 9:55 am - 10:35 am | Jacqueline Veltmaat (Childrens Hospital Los Angeles, USA)
"The role of Gli3 in the initiation of mammogenesis" |
| 10:35 am - 10:55 am | Coffee Break |
| 10:55 am - 11:35 am | Han-Sung Jung (Yonsei University, Seoul, Korea)
"Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryos" |
| 11:35 am - 12:15 pm | David Salomon (National Institutes of Health, USA)
"Cripto: A Novel Mammary Morphogen and Oncogene" |
| 12:15 pm - 12:30 pm | Mark D. Sternlicht (UCSF Department of Anatomy, San Francisco, USA)
"Epithelial TACE, amphiregulin and paracrine activation of stromal EGFR are required for mammary gland branching morphogenesis" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 2:00 pm - 4:00 pm | Optional Informal Workshop: "Imaging The Mammary Gland" |
| 4:00 pm - 5:30 pm | Poster Session I |
| 5:30 pm - 7:30 pm | Lactation/Lipid secretion |
| 5:30 pm - 5:45 pm | Discussion Leader: Margaret Neville (University of Colorado Health Sciences Centre, Denver, USA) |
| 5:45 pm - 6:20 pm | Steve Anderson (University of Colorado Health Sciences Centre, Denver, USA)
"Lactation defects in Src and Akt mutant mice" |
| 6:20 pm - 6:55 pm | Tiffany Seagroves (University of California San Diego, USA)
"Functional Consequences of Conditional Inactivation of the Hypoxia-Inducible Factor (HIF)-1 Pathway" |
| 6:55 pm - 7:30 pm | Kevin Nicholas (University of Melbourne, Australia)
"The tammar wallaby and the Australian fur seal: comparative genomics of models with extreme adaptation to lactation" |
| 8:00 pm | Dinner |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cancer Models |
| 9:00 am - 9:15 am | Moderator: Mina Bissell (Lawrence Berkeley Laboratory) |
| 9:15 am - 9:55 am | Peter Sicinski (Harvard Medical School, Boston, USA)
"Cyclin D-CDK function in development and mammary tumorigenesis" |
| 9:55 am - 10:35 am | Senthil Muthuswamy (Cold Spring Harbor Laboratory, New York, USA)
"ErbB2-induced transformation of polarized epithelia" |
| 10:35 am - 10:55 am | Coffee Break |
| 10:55 am - 11:35 am | Kornelia Polyak (Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA)
"Molecular characterization of epithelial-stromal cell interactions in breast tumorigenesis" |
| 11:35 am - 12:15 pm | TBA |
| 12:15 pm - 12:30 pm | Short presentation |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session II |
| 5:30 pm - 7:30 pm | Apoptosis and Involution |
| 5:30 pm - 6:00 pm | Moderator: Andrew Wyllie (University of Cambridge, UK)
"Overview of cell death pathways" |
| 6:00 pm - 7:30 pm | Hot topics from young investigators |
| 6:00 pm - 6:20 pm | Paul Came (Department of Pathology, Cambridge, UK)
"The role of IKK2/ß in the induction of apoptosis during involution" |
| 6:20 pm - 6:40 pm | Tracy Lyons (University of Colorado Health Sciences Center, Denver, USA)
"Proteomic Analysis: Akt Substrates in the Mammary Gland" |
| 6:40 pm - 7:00 pm | Mathew Naylor (University of Manchester, UK) |
| 7:00 pm - 7:20 pm | TBA |
| Business meeting |
| 8:00 pm | Dinner |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Signaling/Guidance/Cell fate pathways |
| 9:00 am - 9:15 am | Moderator: Barbara Vonderhaar (Center for Cancer Research, NCI, National Institutes of Health, USA) |
| 9:15 am - 9:55 am | Lindsay Hinck (University of California, Santa Cruz, USA)
"Netrin-1 and Slit-2 Collaborate to Stabilize Interactions during Mammary Gland Development" |
| 9:55 am - 10:35 am | Jane Visvader (The Walter and Eliza Hall Institute, Melbourne, Australia)
"Role of the zinc finger protein LMO4 and its partners in mammary gland development and breast cancer" |
| 10:35 am - 10:55 am | Coffee Break |
| 10:55 am - 11:35 am | Sean Egan (The Hospital for Sick Children, Toronto, Canada)
"Regulation of mammary gland development and breast cancer by Notch signaling" |
| 11:35 am - 11:50 am | Nathalie Cella (Baylor College of Medicine, Houston, USA)
"Maspin modulates mammary cell-extracellular matrix interaction" |
| 11:50 am - 12:30 pm | Michael Karin (UCSD School of Medicine, La Jolla, USA)
"IKKα and breast tumorigenesis" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session II |
| 5:30 pm - 7:30 pm | Keynote Address |
| 5:30 pm - 6:00 pm | Introductory remarks |
| 6:00 pm - 7:00 pm | Jeff Rosen (Baylor College of Medicine, Houston, USA)
"From milk protein gene expression to mammary stem cells: the evolution of mammary gland biology" |
| 7:00 pm - 8:00 pm | Closing Remarks and Reception |
| 8:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
