SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | KEYNOTE: THE CHALLENGE OF BREAST CANCER |
7:30 pm - 8:00 pm | Jeffrey W. Pollard (Albert Einstein College of Medicine)
"Chair's Introduction" |
8:00 pm - 9:00 pm | Keynote Lecture 1: Tak W. Mak (Princess Margaret Hospital)
"Cancer Therapeutics: Have we been kissing the wrong frogs?" |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | EPITHELIAL MESENCHYMAL INTERACTIONS IN BREAST CANCER |
9:00 am - 9:10 am | Discussion Leader: Terry L. Wood (Penn State College of Medicine) |
9:10 am - 9:50 am | Lewis A. Chodosh (University of Pennsylvania)
"Oncogene Dependence and Breast Cancer Progression" |
10:00 am | Coffee Break |
10:30 am - 11:10 am | Claire E. Lewis (University of Sheffield Medical School)
"Macrophage responses to hypoxia in breast tumors: implications for tumour progression and anti-cancer therapies" |
11:10 am - 11:50 am | John Condeelis (Albert Einstein College of Medicine)
"Identification of an invasion signature and its mechanism of action in mammary tumor metastasis" |
11:50 am - 12:10 pm | Derek C. Radisky (Lawrence Berkeley National Laboratory)
"Matrix metalloproteinase-induced malignancy in mouse mammary epithelial cells" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | DEVELOPMENTAL TRANSITIONS I |
7:30 pm - 7:50 pm | Discussion Leader: Charles Streuli (University of Manchester) |
7:50 pm - 8:30 pm | Anthony M.C. Brown (Weill Medical College of Cornell University)
"Wnt signaling in mammary development: specificity, diversity, and functions" |
8:30 pm - 9:10 pm | Caroline M. Alexander (University of Wisconsin Medical School)
"Stem Cells and Cancer: what can Syndecan and Wnt tell us" |
9:10 pm - 9:25 pm | Shaolei Lu (University Of Massachusetts)
"Microarray analysis of hormonal treated mammary gland reveals the role of extracellular matrix in p53 activities" |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | DEVELOPMENTAL TRANSITION II |
9:00 am - 9:15 am | Discussion Leader: Pamela Cowin (NYU Medical School) |
9:15 am - 10:00 am | Robert Rhoads (Louisiana State University Health Sciences Center)
"Regulation of milk protein synthesis by insulin and prolactin at the translational level" |
10:00 am | Coffee Break |
10:30 am - 11:10 am | Christine J. Watson (University of Cambridge)
"Essential regulators of apoptosis in mammary gland involution" |
11:10 am - 11:50 am | Cynthia A. Zanhow (Sidney Kimmel Cancer Center at John Hopkins)
"Translational regulation of C/EBPb by receptor tyrosine kinases: implications for mammary development and breast cancer" |
11:50 am - 12:30 pm | Gertraud Robinson (National Institute of Health)
"Regulation of mammary gland development by cytokine and Notch signals" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | SIGNALING PATHWAYS IN MAMMARY DEVELOPMENTAL AND CANCER |
7:30 pm - 7:40 pm | Discussion Leader: Robert B. Clarke (University of Manchester) |
7:40 pm - 8:20 pm | Leena Hilakivi-Clarke (Georgetown University School of Medicine)
"Changes in mammary gland morphology and gene signaling pathways following early life dietary exposures: do they explain altered breast cancer risk?" |
8:20 pm - 9:00 pm | Gabriela Dontu (University of Michigan)
"Signal transduction pathways in mammary stem cells" |
9:00 pm - 9:15 pm | Tan A. Ince (Whitehead Institute)
"Cell of origin determines histological type, tumorigenicity and metastatic behavior of breast tumors" |
9:15 pm - 9:30 pm | Julie Ostrander (University of Minnesota)
"Regulated Association of PKB/Akt with Breath Tumor Kinase (Brk)" |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | LACTATION |
9:00 am - 9:15 am | Discussion Leader: Steve Anderson (University of Colorado) |
9:15 am - 10:00 am | John J. Wysolmerski (Yale University School of Medicine)
"Calcium handling and sensing by the lactating mammary gland: How the breast talks to bone" |
10:00 am | Coffee Break |
10:30 am - 11:10 am | James McManaman (University of Colorado Health Sciences Center)
"Regulation of Milk Lipid Formation and Secretion" |
11:10 am - 11:50 am | Christopher Linington (University of Aberdeen)
"Milk to multiple sclerosis: molecular mimicry with butyrophilin modulates disease activity in CNS autoimmune disease" |
11:50 am - 12:30 pm | Sarah D. Berry (Vialactia Biosciences Ltd.)
"Nature's variation: A tool for understanding lactation biology" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PEPTIDE HORMONE SIGNALING AND GROWTH FACTORS |
| Discussion Leader: Nancy Hynes (Friedrich Miescher Institute) |
7:30 pm - 8:05 pm | Christopher J. Ormandy (Garvan Institute of Medical Research)
"Discovery of genes mediating the influence of prolactin during mammary gland development" |
8:05 pm - 8:40 pm | Mary Helen Barcellos-Hoff (Lawrence Berkeley National Laboratory)
"Mammary responses to DNA damage and the role of TGFß" |
8:40 pm - 9:05 pm | Malinda Stull (University of Cincinnati)
"Serotonergic mechanisms of homeostasis and cell death regulation in mammary gland" |
9:05 pm - 9:30 pm | Sasha J. Howell (University of Manchester)
"Inhibition of breast cancer growth in vitro with the prolactin receptor antagonist Δ1-9 G129R-hPrl" |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CELL CYCLE, DNA REPAIR PATHWAYS, CHROMOSOMAL ABNORMALITIES AND BREAST CANCER |
9:00 am - 9:15 am | Discussion Leader: Jeffrey M. Rosen (Baylor College of Medicine) |
9:15 am - 10:00 am | Joseph D. Jerry (University of Massachusetts)
"DNA Repair Pathways as Genetic Modifiers of Breast Cancer Susceptibility" |
10:00 am | Coffee Break |
10:30 am - 11:10 am | Joe W. Gray (Lawrence Berkeley National Laboratory)
"Genomics causes and consequences of malignant progression in breast cancer" |
11:10 am - 11:50 am | Ralph Scully (Harvard Institute of Medicine)
"Recombination functions of BRCA1 and H2AX" |
11:50 am - 12:30 pm | Elizabeth Musgrove (Garvan Institute)
"Cell cycle control by Id helix-loop-helix proteins" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | KEYNOTE ADDRESS 2 |
7:30 pm - 7:45 pm | Chair: Jeffrey W. Pollard (Albert Einstein College of Medicine) |
7:45 pm - 8:45 pm | Keynote Lecture 2: Robert Weinberg (Whitehead Institute)
"Pathogenesis of Invasive Mammary Tumors" |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |