SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | OPENING ADDRESS |
| Discussion Leader: Steven M. Anderson (University of Colorado Health Sciences Center) |
7:30 pm - 8:00 pm | Introductory Comments by GRC Site Staff / Welcome by Conference Chair |
8:00 pm - 9:00 pm | Joan Massague (Memorial Sloan-Kettering Cancer Center) "Genes that mediate breast cancer metastasis" |
9:30 pm | Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | STEM CELLS IN MAMMARY GLAND DEVELOPMENT AND TUMORIGENESIS |
9:00 am - 9:05 am | Discussion Leader: Caroline M. Alexander (McArdle Laboratory for Cancer Research, University of Wisconsin) |
9:05 am - 9:35 am | Jeff Rosen (Baylor College of Medicine) "Stem cells in development and cancer" |
9:35 am - 9:50 am | Discussion |
9:50 am | Coffee Break / Group Photo |
10:20 am - 10:50 am | Max Wicha (University of Michigan Medical School) "Regulation of self-renewal in mammary stem cells" |
10:50 am - 11:05 am | Discussion |
11:05 am - 11:35 am | Lothar Hennighausen (National Institutes of Health) "The hematopoietic system as a teacher of the mammary gland" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Brian Booth (National Cancer Institute) "Evidence for a tumorigenic multipotent cell in ErbB2 mammary carcinomas" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Peter Eirew (Terry Fox Laboratory) "Characterization of normal human mammary stem cells using a xenotransplant model" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
7:30 pm - 9:30 pm | DEVELOPMENT OF THE MAMMARY GLAND |
7:30 pm - 7:35 pm | Discussion Leader: Cathrin Brisken (Swiss Institute for Experimental Cancer Research) |
7:35 pm - 8:05 pm | Jacqueline Veltmaat (Institute of Molecular and Cell Biology, Singapore) "Entry into the milky way" |
8:05 pm - 8:25 pm | Discussion |
8:25 pm - 8:55 pm | Pam Cowin (New York University) "Patterning and Adhesion in Breast Development and Cancer" |
8:55 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Alexandra Pietersen (Netherlands Cancer Institute, Amsterdam) "The role of Bmi1 in mammary gland development and breast cancer" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Free Time |
12:30 pm | Lunch |
1:00 pm - 4:30 pm | CANCER MODELS |
1:00 pm - 1:05 pm | Discussion Leader: William J. Muller (McGill University) |
1:05 pm - 1:35 pm | Linda Schuler (University of Wisconsin) "Prolactin-dependent mammary tumorigenesis" |
1:35 pm - 1:50 pm | Discussion |
1:50 pm | Coffee Break |
2:20 pm - 2:50 pm | Kathryn L. Schwertfeger (University of Minnesota) "The role of inflammation in early stages of mammary tumorigenesis" |
2:50 pm - 3:05 pm | Discussion |
3:05 pm - 3:35 pm | Alana Welm (University of Utah) "Molecular signature of breast cancer: mouse to human correlation" |
3:35 pm - 3:50 pm | Discussion |
3:50 pm - 4:05 pm | Erica McCoy (University of Colorado Health Sciences Center) "In vivo role of Six1 homeoprotein in mammary gland tumorigenesis" |
4:05 pm - 4:10 pm | Discussion |
4:10 pm - 4:25 pm | Beatrice Howard (Institute of Cancer Research, London) "Neuregulin3 alters cell fate in the epidermis and mammary gland" |
4:25 pm - 4:30 pm | Discussion |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | TRANSLATION TO THE CLINIC |
7:30 pm - 7:35 pm | Discussion Leader: Carol Lange (University of Minnesota) |
7:35 pm - 8:05 pm | Carlos Arteaga (Vanderbilt Medical School) "EGF Receptor family inhibitors in the treatment of breast cancer: From the Bench to Bedside and Back Again" |
8:05 pm - 8:20 pm | Discussion |
8:20 pm - 8:50 pm | Douglas Yee (University of Minnesota) "The IGF1 receptor as a target for clinical intervention" |
8:50 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Kristopher Lofgren (University of Minnesota) "Breast tumor kinase mediated signaling and mammary gland biology relevant to breast cancer" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | TUMOR METABOLISM AS A THERAPUTIC TARGET |
9:00 am - 9:05 am | Discussion Leader: D. Joseph Jerry (University of Massachusetts at Amherst) |
9:05 am - 9:35 am | Rakest Kumar (Glaxo Smith Kline) "Discovery of a novel AKT kinase inhibitor with potent anti-tumor activity" |
9:35 am - 9:50 am | Discussion |
9:50 am | Coffee Break |
10:20 am - 10:50 am | Paul M. Hwang (NHLBI, NIH) "p53 regulates mitochondrial function-a link to the Warburg Effect?" |
10:50 am - 11:05 am | Discussion |
11:05 am - 11:35 am | William B. Kinlaw (Dartmouth Medical School) "Lipid metabolism in breast cancer; Role of Spot 14 and lipoprotein lipase" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Avtar Roopra (University of Wisconsin) "The Warburg effect remodels chromatin around pro-metastatic genes via the tumor suppressor REST/NRSF: implications for therapy" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Derek LeRoith (Mt. Sinai School of Medicine) "Type2 diabetes is associated with increased breast cancer: use of mouse models to dissect the possible mechanism" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | THE LACTATION SWITCH |
7:30 pm - 7:35 pm | Discussion Leader: Ian Mather (University of Maryland) |
7:35 pm - 8:05 pm | Dean P. Edwards (Baylor College of Medicine) "Regulation of Β-casein transcription by the progesterone receptor and Stat5" |
8:05 pm - 8:20 pm | Discussion |
8:20 pm - 8:50 pm | Lewis Chodosh (University of Pennsylvania School of Medicine) "Role of Akt isoforms in metabolism and lactation" |
8:50 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Elizabeth Wellberg (Texas A&M) "Overexpression of Singleminded-2s triggers partial activation of the lactogenic program" |
9:20 pm - 9:25 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | THE INVOLUTION SWITCH |
9:00 am - 9:05 am | Discussion Leader: Terri Wood (University of Medicine and Dentistry of New Jersey) |
9:05 am - 9:35 am | Darryl Hadsell (Baylor College of Medicine) "Regulation of Mammary Cell Function and Turnover During The Lactation Cycle" |
9:35 pm - 9:50 am | Discussion |
9:50 am | Coffee Break |
10:20 am - 10:50 am | Christine Watson (Cambridge University) "The role in inflammatory genes in involution" |
10:50 am - 11:05 am | Discussion |
11:05 am - 11:35 am | Peter Henson (National Jewish Center for Research and Medicine) "Clearance of apoptotic cells from the involuting mammary gland" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Richard Clarkson (Cardiff University) "The NF-kB co-factor Bcl3 promotes apoptosis in the involuting mammary gland" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Edith C. Kordon (Ciudad Universitaria, Buenos Aires) "Mechanical stress induces involution associated events in mammary epithelial cells" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | KEYNOTE ADDRESS |
7:30 pm - 7:35 pm | Discussion Leader: Steven M. Anderson (University of Colorado Health Sciences Center) |
7:35 pm - 8:25 pm | Margaret C. Neville (University of Colorado Health Sciences Center) "Secretory differentiation and activation: questions for the future" |
8:25 pm - 8:50 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |