| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Biology of ectodermal stem cells |
| 7:40 pm - 8:00 pm | Discussion Leader: Cathrin Brisken (ISREC/EPFL, Lausanne)
"Introduction" |
| 8:00 pm - 9:00 pm | Cheng Ming Chuong (University of Southern California, Los Angeles)
"Macro- and micro- environmental regulation of ectodermal organ stem cells" |
| 9:00 pm - 9:10 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Mammary gland: evolution and development |
| 9:00 am - 9:15 am | Discussion Leader: Chris Ormandy (Garvan Institute, Sidney)
"Introduction" |
| 9:15 am - 9:35 am | Henrik Kaessman (Center of Integrative Genomics, University of Lausanne)
"Loss of egg yolk genes in mammals and the origin of lactation and placentation" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 9:55 am | Weston Porter (College Station, A&M University Texas)
"Regulation of Single-minded 2 by Notch and CEBPβ" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break / Group Photo |
| 10:30 am - 10:50 am | Joan Brugge (Harvard Medical School, Boston)
"Cell Death Mechanisms in Mammary Epithelial Cells" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Kai-Uwe Wagner (Eppley Institute, University of Nebraska, Omaha)
"The significance of Jak2/Stat5 signaling for mammary development and tumorigenesis" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Nancy Hynes (Friedrich Miescher Institute, Basel)
"The role of c-Myc in normal mammary gland development and the role of FGFRs in mammary cancer" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Eve Devinoy (UR1196, JOUY EN JOSAS)
"Epigenetic modifications around the mouse and rabbit WAP genes during mammary gland development" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | James McManaman (University of Colorado, Aurora)
"Impaired milk lipid formation inhibits mammary gland differentiation" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Endocrine Disruptors |
| 5:30 pm - 5:45 pm | Discussion Leader: Serge Nef (University of Geneva Medical School)
"Introduction" |
| 5:45 pm - 6:05 pm | Tyrone Hayes (University of California, Berkley)
"Frogs don't have breasts! What amphibians can teach us about the mammary gland" |
| 6:05 pm - 6:15 pm | Discussion |
| 6:15 pm - 6:35 pm | Paolo Mocarelli (University of Milano, Italy)
"Dioxin as an endocrine disruptor in humans: data from the Seveso accident" |
| 6:35 pm - 6:45 pm | Discussion |
| 6:45 pm - 7:05 pm | Ana Soto (Tufts University, Boston)
"Does breast cancer start in the womb?" |
| 7:05 pm - 7:15 pm | Discussion |
| 7:15 pm - 7:25 pm | Gloria Calaf (Tarapaca University, Arica, Chile)
"Breast and lung carcinogenesis induced by organophosphorous pesticides and estrogen" |
| 7:25 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Early stage disease |
| 9:00 am - 9:15 am | Discussion Leader: Joe Jerry (University of Massachusetts-Amherst)
"Introduction" |
| 9:15 am - 9:35 am | Craig Allred (Washington University School of Medicine, St. Louis)
"Apocrine Metaplasia and Breast Cancer: The Clinical Impact of Converging Divergent Pathways" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 9:55 am | Senthil Muthuswamy (Cold Spring Harbor, Long Island)
"Inactivation of the polarity gene Scribble disrupts normal epithelial morphogenesis and promotes mammary tumorigenesis" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Dan Medina (Baylor College of Medicine, Houston)
"A new approach to the study of human DCIS" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Kornelia Polyak (Dana-Farber Cancer Institute, Boston)
"Myoepithelial control of in situ to invasive breast carcinoma transition" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Jorge Reis-Filho (Breast Cancer Breakthrough Center, London)
"Special types of breast cancer: phenotypic-genotypic correlations" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Annabel Zwagstra (Netherland Cancer Institute, Amsterdam)
"Identification and characterization of novel mammary tumor genes" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Lori Friedman (Genentech, San Francisco)
"PI3 Kinase Signaling in Breast Cancer Treatment" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Branching Morphogenesis |
| 5:30 pm - 5:45 pm | Discussion Leader: Marina Glukhova (Institut Curie, Paris)
"Introduction" |
| 5:45 pm - 6:05 pm | Markus Affolter (Biozentrum, University of Basel)
"Branching morphogenesis in flies and fish: a comparison" |
| 6:05 pm - 6:15 pm | Discussion |
| 6:15 pm - 6:35 pm | Tracey Vargo (Indiana University School of Medicine) |
| 6:35 pm - 6:45 pm | Discussion |
| 6:45 pm - 7:05 pm | Seppo Vainio (Biocentre, Oulu)
"Branching morphogenesis in the developing kidney" |
| 7:05 pm - 7:15 pm | Discussion |
| 7:15 pm - 7:25 pm | Ozden Yalcin (ISREC/EPFL, Lausanne)
"Mechanisms of Notch Signaling in Breast Epithelial Cells" |
| 7:25 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Breast stem cells and lineages |
| 9:00 am - 9:15 am | Discussion Leader: Gabriela Dontu (University of Michigan, Ann Arbor)
"Introduction" |
| 9:15 am - 9:35 am | Sendurai Mani (M.D. Anderson Cancer Center, Houston)
"Interesting link between EMT and cancer stem Cells" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 9:55 am | Sung-Hee Baek (University of Seoul, Seoul)
"Molecular Mechanisms of Estrogen Receptor-specific Derepression by TAB2" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Myles Brown (Dana-Farber Cancer Institute, Boston)
"Defining Lineage-Specific Transcriptional Programs" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Robert Clarke (University of Manchester)
"Regulation of breast cancer stem-like cells" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Jane Visvader (The Walter and Eliza Hall Institute, Melbourne)
"Elucidating the stem and progenitor cell hierarchy in mammary development and cancer" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Kara Britt (Breakthrough Centre, London)
"Parity-induced protection against breast cancer: an estrogen sensitive issue" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | John Stingl (Cancer Research UK, Cambridge)
"Two functionally distinct types of ER+ cells exist within the mouse mammary epithelium" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Breast Cancer Models |
| 5:30 pm - 5:45 pm | Discussion Leader: Jeff Rosen (Baylor College of Medicine, Houston)
"Introduction" |
| 5:45 pm - 6:05 pm | Richard Iggo (University of St. Andrews)
"ER positive models of breast cancer made by quantitative transformation of normal mammary epithelial cells" |
| 6:05 pm - 6:15 pm | Discussion |
| 6:15 pm - 6:35 pm | Tan Ince (Harvard Medical School, Boston)
"Cell-of-origin Influence on Breast Tumor Phenotype" |
| 6:35 pm - 6:45 pm | Discussion |
| 6:45 pm - 7:05 pm | Peter Friedl (Rudolf Virchow-Zentrum, Würzburg)
"From individual to collective cell migration" |
| 7:05 pm - 7:15 pm | Discussion |
| 7:15 pm - 7:25 pm | Mejdi Moumen (Institut Curie, Paris)
"Perturbation of β-catenin and p53 pathways in basal mammary cells: effects on mammary development and tumorigenesis" |
| 7:25 pm - 7:30 pm | Discussion |
| 7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 8:00 pm | Dinner |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Control of Stem Cells |
| 9:00 am - 9:15 am | Discussion Leader: Gil Smith (NCI, Bethesda)
"Introduction" |
| 9:15 am - 9:35 am | Konrad Hochedliger (Harvard Medical School, Boston)
"Reprogramming of adult cells into embryonic stem cells" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 9:55 am | Giuseppina Bonizzi (IFOM-IEO, Milano)
"Extended life-span and increased frequency of symmetric self-renewing divisions in cancer stem cells, due to attenuated p53 signaling" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Micheal Lewis (Baylor College of Medicine, Houston)
"Non-canonical hedgehog signaling and mammary stem/progenitor cells" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Jim DiRenzo (Dartmouth Medical School)
"Reciprocal Interactions between TP63 and Hedgehog Signaling Regulate Quiescence and Activation of Mammary Stem Cells" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Maria Vivanco (Centro de Investigacion Coperative de Bioscincias, Bilbao)
"Analysis of human breast stem/progenitor cell growth and differentiation" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Keith Brennan (University of Manchester, Manchester)
"Notch signalling regulates apoptosis in breast epithelial cells through Akt" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Susana Garcia Silva (EMBL-Monterotondo, Rome)
"C/EBPβ is a relevant factor for the stem/progenitor homeostasis of the mammary gland" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Keynote Address |
| 5:30 pm - 5:40 pm | Discussion Leader: Cathrin Brisken (ISREC/EPFL, Lausanne)
“Introductory Remarks” |
| 5:40 pm - 6:10 pm | Bruce Ponder (Cancer Research UK, Cambridge)
“Breast Cancer Susceptibility” |
| 6:10 pm - 6:20 pm | Discussion |
| 6:20 pm - 7:20 pm | Speaker (TBA) |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
