SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Manipulating Tissue-Specific Stem Cells |
7:40 pm - 8:00 pm | Welcome and Introduction by Conference Chairs |
| Discussion Leader: D. Joseph Jerry (University of Massachusetts-Amherst) |
8:00 pm - 9:00 pm | Lola Reid (University of North Carolina-Chapel Hill, USA) "Human hepatic stem cells, their descendant maturational lineages of parenchymal cells, and their relations to other endodermal stem cell populations" |
9:00 pm - 9:20 pm | Discussion |
9:30 pm | Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Regulation of Development by Hormones & Growth Factors |
9:00 am - 9:05 am | Discussion Leader: Chris Ormandy (Garvan Institute, Australia) |
9:05 am - 9:40 am | John Lydon (Baylor College of Medicine, USA) "Mammary epithelial responses to progesterone: morphological, cellular and molecular insights from mouse studies" |
9:40 am - 9:55 am | Discussion |
9:55 am - 10:05 am | Short Talk: Rumela Chakrabarti (State University of New York at Buffalo) "Elf5 deficiency in mammary epithelium leads to cell fate changes associated with altered notch activity" |
10:05 am - 10:10 am | Discussion |
10:10 am | Coffee Break / Group Photo (10:15 am) |
10:35 am - 11:10 am | Sean Egan (Hospital for Sick Children, Canada) "Notch signaling in mammary gland development and breast cancer" |
11:10 am - 11:25 am | Discussion |
11:25 am - 12:00 pm | Christine Watson (University of Cambridge, UK) "Signaling and lineage commitment in mammary gland" |
12:00 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short Talk: Jessica McCready (Tufts University) "Lactating derived stromal cells promote breast cancer development" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 1 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Stem Cells: Puppets or Puppeteers? |
7:30 pm - 7:35 pm | Discussion Leader: Jeffrey Rosen (Baylor College of Medicine, USA) |
7:35 pm - 8:10 pm | Jeffrey Rosen (Baylor College of Medicine, USA) "Breast Cancer Stem Cells: To Believe or Not to Believe" |
8:10 pm - 8:25 pm | Discussion |
8:25 pm - 9:00 pm | Amar Klar (National Cancer Institute-Frederick, USA) "Asymmetric cell division through selective chromatid segregation as a general mechanism for cellular differentiation" |
9:00 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Short Talk: Brian Booth (Clemson University) "Human embryonal carcinoma cells are differentiated by the mouse mammary microenvironment" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Parity: Protection or Prevention |
9:00 am - 9:05 pm | Discussion Leader: Daniel Medina (Baylor College of Medicine, USA) |
9:05 am - 9:40 am | Pepper Schedin (University of Colorado Health Science Center, USA) "The involution hypothesis and pregnancy-associated breast cancer" |
9:40 am - 9:55 am | Discussion |
9:55 am - 10:05 am | Short Talk: Rajkumar Lashmanaswamy (Texas Tech Univ. Health Sciences Center) "Early pregnancy, hormones and breast cancer risk" |
10:05 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:35 am - 11:10 am | Melissa Troester (University of North Carolina-Chapel Hill, USA) "Population Variation in Parity-Associated Gene Expression" |
11:10 am - 11:25 am | Discussion |
11:25 am - 12:00 pm | Kornelia Polyak (Dana-Farber Cancer Institute, USA) "Microenvironmental regulation of breast cancer progression" |
12:00 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short Talk: Robert Clarke (University of Manchester) "Normal breast tissue implanted into athymic nude mice identifies biomarkers of the effects of human pregnancy levels of estrogen" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 1 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Breast Cancer Pathways |
7:30 pm - 7:35 pm | Discussion Leader: John Hilkens (The Netherlands Cancer Institute) |
7:35 pm - 8:10 pm | Andrew Futreal (Wellcome Trust Sanger Institute, UK) "Structural somatic genetics of breast cancer" |
8:10 pm - 8:25 pm | Discussion |
8:25 pm - 9:00 pm | Jeffrey Green (National Cancer Institute, USA) "Exploiting genomic analyses for pre-clinical testing in mouse models of mammary cancer" |
9:00 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Short Talk: Jun-Lin Guan (University of Michigan) "FAK signaling pathways in mammary stem cells and breast cancer" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Responses to Genotoxic Stress: DNA Repair & Autophagy |
9:00 am - 9:05 am | Discussion Leader: D. Joseph Jerry (University of Massachusetts-Amherst, USA) |
9:05 am - 9:40 am | Lisa Wiesmüller (University of Ulm, Germany) "Specific DNA double-strand break repair defects in primary cells from breast cancer specimens and blood predict breast cancer risk" |
9:40 am - 9:55 am | Discussion |
9:55 am - 10:05 am | Short Talk: Esta Sterneck (National Cancer Institute) "C/EBPdelta is a mammary tumor suppressor promoting DNA damage and hypoxia response" |
10:05 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:35 am - 11:10 am | David Livingston (Dana Farber Cancer Institute, USA) "Functional analysis of the BRCA1 gene products" |
11:10 am - 11:25 am | Discussion |
11:25 am - 12:00 pm | Vassiliki Karantza-Wadsworth (UMDNJ-Robert Wood Johnson Medical School, USA) "Role of autophagy in mammary gland biology and tumorigenesis" |
12:00 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short Talk: Kristine Klos (University of Wisconsin – Madison) "Lineage-Specific Responses to Carcinogen Exposure in Mammary Epithelial Cell Populations" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 2 |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Environmental Carcinogenesis |
7:30 pm - 7:35 pm | Discussion Leader: Weston Porter (Texas A&M University, USA) |
7:35 pm - 8:10 pm | Cheng Chi Lee (University of Texas-Houston Medical Center, USA) "Circadian clock and cell growth regulation" |
8:10 pm - 8:25 pm | Discussion |
8:25 pm - 9:00 pm | Mary Helen Barcellos-Hoff (New York University Langone School of Medicine, USA) "Breast cancer and the environment: New ideas about radiation as a prototypical carcinogen" |
9:00 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Short Talk: Cynthia Zahnow (The SKCCC at Johns Hopkins) "Exposure of mammary epithelial cells to cigarette smoke leads to transformation, EMT and altered epigenetic regulation" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Adaptating to Lactation |
9:00 am - 9:05 am | Discussion Leader: Russ Hovey (University of California-Davis, USA) |
9:05 am - 9:40 am | Sylvaine Cases (Gladstone Institute of Cardiovascular Disease) "Role of adipocytes in mammary gland development and breast cancer: Lessons from DGAT1-deficient mice" |
9:40 am - 9:55 am | Discussion |
9:55 am - 10:05 am | Short Talk: Fabienne Le Provost (INRA) "Characterization of microRNA functions in mouse mammary gland biology" |
10:05 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:35 am - 11:10 am | Nelson Horseman (University of Cincinnati, USA) "Lactation Homeostasis: Physiological and Pathological Adaptations" |
11:10 am - 11:25 am | Discussion |
11:25 am - 12:00 pm | Ross Tellam (CSIRO, Australia) "What does the Bos tarsus genome sequence say about the genes involved in mammalian lactation?" |
12:00 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short Talk: Darryl Hadsell (Baylor College of Medicine) "A 4X nursing frequency in the mouse decreases milk production, but does not accelerate mammary involution, and has little effect on gene expression, mitochondrial function or IGF-I signaling during prolonged lactation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 2 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Lecture: Perspectives in Mammary Gland Biology |
7:30 pm - 7:45 pm | Discussion Leader: D. Joseph Jerry (University of Massachusetts-Amherst, USA) |
7:45 pm - 8:45 pm | Barbara Vonderhaar (National Cancer Institute, NIH, USA) "Prolactin in breast development and cancer: a journey" |
8:45 pm - 9:10 pm | Discussion |
9:30 pm | Reception |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |