SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 7:50 pm | Welcome and Introduction by the meeting Chairs Christopher Ormandy (Garvan Institute of Medical Research Sydney) Pepper Schedin (Div. Medical Oncology, University of Colorado, Denver) |
7:50 pm - 9:00 pm | INTRODUCTORY ADDRESS |
7:50 pm - 8:45 pm | Rene Bernards (NIK Amsterdam) "Using the genome to improve the diagnosis and treatment of breast cancer" |
8:45 pm - 9:00 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | MAMMARY STEM AND PROGENITOR CELLS |
9:00 am - 9:10 am | Discussion Leader's Overview: Gabriela Dontu (Kings College London) |
9:10 am - 9:40 am | Jane Visvader (Walter and Eliza Hall Institute, Melbourne) "Delineating the mammary epithelial hierarchy in human and mouse" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Matt Smalley (Breakthrough Breast Cancer Research Center, The Institute of Cancer Research, London) "Mammary tumours with basal features develop from luminal progenitors in a Brca1 loss of function mouse model" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break / Group Photo |
11:00 am - 11:30 am | Geoffrey Wahl (Salk Institute San Diego) "Identifying, isolating and characterizing mouse mammary stem cells during embryogenesis" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Beatrice Howard (The Institute of Cancer Research London) "Transcriptome analysis of mouse mammary primordial populations identifies potential mediators of mesenchymal-epithelial inductive signalling and cell fate determination" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Rama Khokha (Ontario Cancer Institute Toronto) "Progesterone Effects on Mammary Gland stem cells" |
12:20 pm -12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session I |
5:30 pm - 7:30 pm | CELLS OF ORIGIN OF MAMMARY CANCER |
5:30 pm - 5:40 pm | Discussion Leader’s Overview: Barry Gusterson (University of Glasgow) |
5:40 pm - 6:10 pm | Bryan Welm (Huntsman Cancer Institute, Salt Lake City) "Functionally Assessing the Cellular Origins of Breast Cancer Through Targeted Oncogenesis" |
6:10 pm - 6:20 pm | Discussion |
6:20 pm - 6:50 pm | Yi Li (Baylor College of Medicine, Houston) "The cellular origins of breast cancer subtypes: stem/progenitor cells or more differentiated progeny?" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:15 pm | Michael Prater (Cancer Research UK Cambridge Research Institute) "A high proportion of mouse myoepithelial cells have mammary stem cell potential" |
7:15 pm - 7:25 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | METASTASIS |
9:00 am - 9:10 am | Discussion Leader’s Overview: John Condeelis (Albert Einstein Cancer Center New York) |
9:10 am - 9:40 am | Christoph Klein and Anya Krefft (University of Regensburg) "Molecular dissection of early breast cancer dissemination and metastasis" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Xiang Zhang (Cancer Biology and Genetics, Sloan-Kettering Institute, New York) "The mechanisms of Src activation and its role in latent bone metastasis in breast cancer" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | John Condeelis (Albert Einstein Cancer Center New York) "The Tumor Microenvironment Invasion Model: new insights into breast cancer metastasis" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Joan Jones (Weill/Cornell Medical College, New York) "The Tumor Microenvironment of Metastasis: Clinical applications" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Jill Ranger (Goodman Cancer Centre Montreal) "Pro-tumour immunity and Stat3-mediated metastasis in an ErbB2 model of breast cancer" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session II |
5:30 pm - 7:30 pm | PHENOTYPIC PLASTICITY |
5:30 pm - 5:40 pm | Discussion Leader’s Overview: Pepper Schedin (University of Colarado, Denver) |
5:40 pm - 6:10 pm | Gil Smith (NCI, Bethesda) "Reprogramming cells in the developing mammary gland" |
6:10 pm - 6:20 pm | Discussion |
6:20 pm - 6:50 pm | Wenjun Guo (Whitehead Institute, Cambridge) "Induction of mammary stem cells by epithelial-mesenchymal transition" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:15 pm | Giuseppina Bonizzi (IFOM-IEO Milan) "p53 and p21 regulate polarity of self-renewing divisions in mammary stem cells" |
7:15 pm - 7:25 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | EPIGENETIC REGULATION |
9:00 am - 9:10 am | Discussion Leader’s Overview: Susan Clark (Garvan Institute of Medical Research, Sydney) |
9:10 am - 9:40 am | Kornelia Polyak and Sigbat Choudhury (Dana Faber Cancer Institute, Boston) "Molecular alterations induced by pregnancy in human mammary epithelial cells" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Thea Tlsty (Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco) "Extrinsic Control of Epigenetic Modifications in Breast Epithelial Cells" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Susan Clark (Garvan Institute of Medical Research, Sydney) "Deregulation of the Breast Cancer Epigenome" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Monique Rijnkels (Baylor College of Medicine Houston) "Chromatin landscape of mammary gland development and functional differentiation" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Xing Dai (U.C. Irvine) "Pygo2, Wnt signaling, and histone modification in mammary epithelial cells" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session III |
5:30 pm - 7:30 pm | GENOMIC REGULATORY NETWORKS |
5:30 pm - 5:40 pm | Discussion Leader’s Overview: Nancy Hynes (Friedrich Miescher Institute, Basel) |
5:40 pm - 6:10 pm | Michael Clarke (Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Palo Alto) "Regulation of mammary stem cells by microRNAs" |
6:10 pm - 6:20 pm | Discussion |
6:20 pm - 6:50 pm | Jason Carroll (Cancer Research UK Cambridge Research Institute) "Genomic approaches for defining estrogen receptor function" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:15 pm | Angela Burleigh (Cancer Research Center Vancouver) "Systematic Identification of Signal Transducers Required for Mammary Epithelial Cell Growth" |
7:15 pm - 7:25 pm | Discussion |
7:25 pm - 7:50 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | MAMMOGRAPHIC DENSITY |
9:00 am - 9:10 am | Discussion Leader’s Overview: Malcolm Pike (Norris Comprehensive Cancer Center Los Angeles) |
9:10 am - 9:40 am | Anna Wu (University of Southern California) and Malcolm Pike (Norris Comprehensive Cancer Center Los Angles) "Mammographic Density: Epidemiology, Modifying Factors and Predictors of Modified Risk" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Norman Boyd (Ontario Cancer Institute, Toronto) "Breast tissue composition in young women" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Bengt Nielsen (General Manager Academic Program GE Healthcare, Stockholm) "Breast imaging today and in the future" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Jodi Flemming (NIH Bethesda) "The normal breast microenvironment of pre-menopausal women differentially influences the behavior of breast cancer cells in vitro and in vivo" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Kelli Valdez (University of Kansas Medical Center Kansas City) "Development of a reproducible human primary ductal carcinoma in situ (DCIS) progression model by the mouse intraductal (MIND) method" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session IV |
5:30 pm - 7:30 pm | KEYNOTE ADDRESS |
5:30 pm - 5:40 pm | Introduction: Christopher Ormandy (Garvan Institute of Medical Research, Sydney) |
5:40 pm - 6:40 pm | Charles Streuli (Wellcome Trust Centre for Cell-Matrix Research, University of Manchester) "Integrins in mammary gland biology and breast cancer" |
6:40 pm - 6:55 pm | Discussion |
6:55 pm - 7:00 pm | Final comments and hand over to Pepper Schedin, Chair 2011 |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |