SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Introductory Comments by GRC Site Staff / Welcome by Conference Chairs |
7:45 pm - 9:00 pm | Keynote Address |
7:45 pm - 7:50 pm | Discussion Leader: Pepper Schedin (University of Colorado Anschutz Medical Campus, Denver, Colorado, USA) |
7:50 pm - 8:45 pm | Kevin Struhl (Harvard Medical School, Boston, Massachusetts, USA)
"An epigenetic switch linking inflammation to cancer and selective inhibition of breast cancer stem cells by metformin" |
8:45 pm - 9:00 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Plasticity of the Mammary Epithelial Cell |
9:00 am - 9:10 am | Discussion Leader: Christine Watson (University of Cambridge, England) |
9:10 am - 9:35 am | Lindsay Hinck (University of California Santa Cruz, Santa Cruz, California, USA)
"Neuronal circuitry in the MEC" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Rebecca S. Muraoka-Cook (Vanderbilt University, Nashville, Tennessee, USA) "MEC as a phagocytic cell; epithelial-directed efferocytosis in the post-partum mammary gland prevents premalignant changes" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Group Photo / Coffee Break |
11:00 am - 11:15 am | Short Talk: Vassiliki Karantza (University of Medicine and Dentistry Medical New Jersey, USA)
"Role of autophagy in mammary involution" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Short Talk: Kathleen H. Goss (University of Chicago, Chicago, Illinois, USA)
"The APC tumor suppressor controls mammary epithelial cell polarization and morphogenesis" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Short Talk: Mark A. LaBarge (Laurence Berkeley Laboratory, California, USA)
"Aging process in mammary gland leads to attenuation of tumor suppressive epithelial lineages and increased proportions of luminal progenitors" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Short Talk: Ana Rocha (IRIBHM, Brussels, Belgium)
"Distinct unipotent stem cells contribute to the development and homeostasis of the mammary gland" |
12:15 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 1 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Lifestyle Risk Factors, Does Altered Mammary Development Provide Insight? |
7:30 pm - 7:40 pm | Discussion Leader: Andrew Ewald (Johns Hopkins School of Medicine, Baltimore, Maryland, USA) |
7:40 pm - 8:05 pm | Graham Colditz (Washington University School of Medicine, St. Louis, Missouri, USA) "Epidemiologic perspective on lifestyle risk factors for breast cancer" |
8:05 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Russ Hovey (University of California, Davis, California, USA) "Dietary fat intake during puberty and mammary gland development" |
8:45 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Short Talk: Victoria Seewaldt (Duke University, Durham, North Carolina, USA)
"Evidence for the Warburg Effect in Mammary Atypia from High-Risk Women" |
9:15 pm - 9:25 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Matrix Mechanics Meets Morphogenesis and Malignancy |
9:00 am - 9:10 am | Discussion Leader: Carlos Sonnenschein (Tufts University, Boston, Massachusetts, USA) |
9:10 am - 9:35 am | Valerie M. Weaver (University of California, San Francisco, California, USA) "Force Journey of a Tumor Cell" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Patricia J. Keely (University of Wisconsin, Madison, Wisconsin, USA) "Molecular imaging of tumor cell signaling in response to the changing stromal landscape" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Melody Swartz (Ecole Polytechnique Federale de Lausanne, Switzerland) "Tumor-lymphatic interactions in the manipulation of host anti-tumor immunity" |
11:25 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Short Talk: Eline Boghaert (Princeton University, Princeton, New Jersey, USA)
"Host epithelial geometry regulates breast cancer cell invasiveness" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Short Talk: Andrew J. Ewald (Johns Hopkins University, Baltimore, Maryland, USA)
"Coordinate regulation of mammary epithelial dissemination by classical cadherins and the ECM microenvironment" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 2 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Stromal Regulation of Cell Signaling |
7:30 pm - 7:35 pm | Discussion Leader: Weston Porter (Texas A&M University, College Station, Texas, USA) |
7:35 pm - 8:00 pm | Joyce A. Schroder (The University of Arizona, Tucson, Arizona) "Searching for the achilles heel of EGFR: using developmental cues to design novel therapies" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Michael P. Lisanti (Thomas Jefferson University, Philadelphia, Pennsylvania) "Loss of Caveolin-1 in breast cancer associated fibroblasts creates a lethal tumor microenvironment" |
8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:10 pm | Short Talk: Irena S. Babina (Royal College of Surgeons in Ireland, Dublin, Ireland)
"Lipid raft affiliation of CD44 is associated with decreased motility of breast cancer cells" |
9:10 pm - 9:20 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | EMT in Normal, Fibrotic and Cancer Development |
9:00 am - 9:10 am | Discussion Leader: Derek C. Radisky (Mayo Clinic Cancer Center, Jacksonville, Florida, USA) |
9:10 am - 9:35 am | Harold A. Chapman (University of California, San Francisco, California, USA) "Integrins in developmental EMT and fibrosis" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Jennifer Richer (University of Colorado Anschutz Medical Campus, Denver, Colorado, USA) "miRNAs as guardians of the epithelial phenotype" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Jenny C. Chang (Methodist Hospital, Houston, Texas, USA) "EMT induced by chemotherapy, a clinical concern" |
11:25 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Short Talk: Theresa Proia (Whitehead Institute for Biomedical Research, Massachusetts, USA)
"BRCA1 mutations impair breast epithelial differentiation through upregulation of the transcriptional factor slug" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Short Talk: Karoline J. Briegel (University of Miami, Miami, Florida, USA)
"The T-box transcription factor TBX2 regulates breast cancer invasiveness through potent activation of EMT" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 3 |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Lactation from a Systems Perspective |
7:30 pm - 7:40 pm | Discussion Leader: Peggy Neville (University of Colorado Anschutz Medical Campus, Denver, Colorado, USA) |
7:40 pm - 8:05 pm | Katie Hinde (California National Primate Research Center, University of California Davis, California, USA) "Milk Synthesis from a Life History Perspective in a Nonhuman Primate Model" |
8:05 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | John J. Wysolmerski (Yale University School of Medicine, New Haven, Connecticut, USA) "Got milk? Got Breast Cancer? The role of calcium pumps during milk production and in breast cancer" |
8:45 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Short Talk: Michael C. Rudolph (University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA)
"THRSP is necessary for complete activation of de novo fatty acid synthesis enzyme acetyl-coA carboxylase 1 in lactating mammary epithelium" |
9:15 pm - 9:25 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Host Regulation of Cell Fate |
9:00 am - 9:10 am | Discussion Leader: Matthew Smalley (Breakthrough Breast Cancer Centre Institute of Cancer Research, United Kingdom) |
9:10 am - 9:35 am | Sandra Haslam (Michigan State University, East Lansing, Michigan, USA)
"Hormonal effects of inflammation in the pubertal verses adult mammary gland" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Cathrin Brisken (Ecole Polytechnique Fédérale de Lausanne, Switzerland) "How hormones impinge on mammary stem cells" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:45 am | Special Lecture: Robert A. Weinberg (Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA) "EMT in normal MEC increases regenerative capacity" |
11:45 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Short Talk: Fabienne Le Provost (National Institute for Agriculture Research, Paris, France)
"Potential Rspo1 involvement in mammary stem cell fate" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 4 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Address |
7:30 pm - 7:45 pm | Discussion Leader: Pepper Schedin (University of Colorado Anschutz Medical Campus, Denver, Colorado, USA) |
7:45 pm - 8:35 pm | Zena Werb (University of California, San Francisco, California, USA) "Branch points in science and career" |
8:35 pm - 9:00 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |