SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:45 pm - 9:15 pm | WNT SIGNALING AND REGULATION OF STEM CELLS
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| Discussion Leader: Terri Wood (New Jersey Med School Cancer Center/UMDNJ)
"Introduction" |
7:50 pm - 8:50 pm | Roel Nusse (Howard Hughes Medical Institute, Stanford University)
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8:50 pm - 9:15 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | RISK FACTORS IN BREAST CANCER |
9:00 am - 9:10 am | Discussion Leader: Victoria Seewaldt (Duke University Medical Center)
"Introduction" |
9:10 am - 9:35 am | Derek LeRoith (Mt. Sinai School of Medicine)
"The role of hyperinsulinemia and hyperlipidemia in accelerating breast cancer in genetic animal models of obesity and diabetes"
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9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Charlotte Kuperwasser (Tufts University School of Medicine)
"BRCA1-haploinsufficiency: Unraveling a cell-type and tissue-specific basis for increased risk and aggressiveness of inherited breast cancer"
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10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | RosaAnna DeFilippis (University of California, San Francisco)
"Mammographic density and breast cancer"
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11:25 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Aaron Boudreau (University of California at San Francisco)
"Identification of long-term favorable outcome in breast cancer"
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11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Daniel Hollern (Michigan State University)
"Human breast cancer and mouse models; similarities and constraints identified through gene expression patterns" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | EFFECTS OF OBESITY AND DIABETES ON LACTATION |
7:30 pm - 7:40 pm | Discussion Leader: Darryl Hadsell (Baylor College of Medicine)
"Introduction" |
7:40 pm - 8:05 pm | Steve Anderson (University of Colorado Medical School)
"Regulation of fatty acid and triglyceride metabolism in the lactating breast and in breast cancer"
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8:05 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | James McManaman (University of Colorado School of Medicine)
"Effects of obesity on milk production, milk lipid synthesis and neonatal metabolism"
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8:45 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Vassiliki Karantza (Cancer Institute of New Jersey)
"ATG proteins mediate efferocytosis and suppress inflammation in mammary involution"
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9:15 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | STEM CELLS AND LUMINAL PROGENITORS IN MAMMARY DEVELOPMENT AND BREAST CANCER
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9:00 am - 9:10 am | Discussion Leader: Rob Clarke (Institute of Cancer Sciences, University of Manchester, Manchester, UK)
"Introduction"
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9:10 am - 9:35 am | Cédric Blanpain (Welbio, Interdisciplinary Research Institute (IRIBHM) Université Libre de Bruxelles (ULB), Belgium)
"Lineage tracing studies examining the contribution of different stem/progenitor cell populations to normal mammary development"
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9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Jane Visvader (Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Australia)
"Contribution of stem/progenitor cell lineages in normal mammary development and breast cancer"
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10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Sean Egan (University of Toronto)
"Defining the cooperative network of oncogenic events in PI3K-induced breast cancer"
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11:25 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Christopher Dravis (Salk Institute for Biological Studies)
"Sox10 expression labels in vitro Mammary Stem Cell activity"
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11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Gwyndolen Harburg (University of California, Santa Cruz)
"The Role of SLIT/ROBO Signaling in Mammary Stem Cells Self-Renewal"
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12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | IGFs/PI3K/AKT SIGNALING IN MAMMARY DEVELOPMENT AND BREAST CANCER
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7:30 pm - 7:40 pm | Discussion Leader: Momo Bentires-Alj (Friedrich Miescher Institute for Biomedical Research, Basel)
"Introduction"
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7:40 pm - 8:05 pm | Adrian V. Lee (University of Pittsburgh Cancer Institute)
"IGF1 and IGF-1R signaling in breast development and cancer"
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8:05 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Lewis Chodosh (University of Pennsylvania School of Medicine)
"Akt in normal mammary gland development and mammary adipocyte differentiation"
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8:45 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Gerjon Ikink (Netherlands Cancer Institute)
"PI3K pathway activating genes collaborating with ErbB2/HER2 in mammary cancer"
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9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ONCOGENES & HORMONE SIGNALING IN MAMMARY
DEVELOPMENT & BREAST CANCER
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9:00 am - 9:10 am | Discussion Leader: Jeff Rosen (Baylor College of Medicine)
"Introduction" |
9:10 am - 9:35 am | Sarah Millar (University of Pennsylvania School of Medicine)
"Wnt/beta-catenin signaling in mammary gland morphogenesis, stem cell proliferation and survival"
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9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Caroline Alexander (University of Wisconsin McArdle Laboratory for Cancer Research)
"LRP receptors in Wnt signaling, mammary stem cell dynamics and breast cancer formation"
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10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Dean Edwards (Baylor College of Medicine)
"Progesterone receptor and Stat5 converge to regulate RANKL and other target gene mediators of proliferation in mammary epithelial cells"
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11:25 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Anupama Chandramouli (New York University School of Medicine)
"The role of Hedgehog signaling in the breast tumor microenvironment"
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11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Fatou Jallow (University of Wisconsin, Madison)
"PRL/TGFa induce ERa-dependent proliferation of mammary epithelial cells and tumorigenesis in the absence of estrogenic ligand"
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12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | GENOMICS AND EPIGENETIC REGULATION OF MAMMARY DEVELOPMENT & BREAST CANCER
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7:30 pm - 7:40 pm | Discussion Leader: Steffi Oesterreich (University of Pittsburgh)
"Introduction"
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7:40 pm - 8:05 pm | Monique Rijnkels (Baylor College of Medicine)
"Chromatin remodeling in mammary gland development" |
8:05 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Anthony Koleske (Yale University School of Medicine)
"Regulation of invadopodia during the transition to an invasive phenotype in breast cancer cells"
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8:45 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Valerie Cortez (UT Health Science Center at San Antonio)
"A novel inducible mammary gland-specific PELP1 murine model"
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9:15 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | BREAST CANCER PROGRESSION & METASTASES |
9:00 am - 9:10 am | Discussion Leader: Nancy Hynes (Friedrich Miescher Institute for Biomedical Research)
"Introduction"
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9:10 am - 9:35 am | Lance Liotta (Center for Applied Proteomics and Molecular Medicine, George Mason University)
"Cancer stem cells with invasive potential in human DCIS lesions" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Kornelia Polyak (Dana-Farber Cancer Institute)
"Molecular profiling of human mammary gland links breast cancer risk to a p27+ cell population with progenitor characteristics"
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10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Alana Welm (Huntsman Cancer Institute, U. Utah)
"Targetable Interactions between breast cancer and bone cells during the formation of osteolytic metastases"
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11:25 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Khalid Mohammad (Indiana University School of Medicine)
"Ryanodine receptor 1 remodeling in breast cancer bone metastases associated muscle dysfunction"
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11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Nina Linde (Mt. Sinai School of Medicine)
"Influence of macrophages and p38a/β signaling on early metastatic dissemination of pre-malignant ErbB2+ mammary epithelial cells"
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12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | KEYNOTE ADDRESS |
7:30 pm - 7:40 pm | John Wysolmerski (Yale University)
"Introduction" |
7:40 pm - 8:40 pm | Christine Watson (Cambridge University)
"From cradle to grave: Biography of an Alveolar Cell"
|
8:40 pm - 9:00 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |