SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session |
| Discussion Leader: Mohamed Bentires-Alj (Friedrich Miescher Institute for Biomedical Research) |
7:55 pm - 8:55 pm | Lewis Cantley (The Cancer Center at Weill Cornell Medical College and NewYork-Presbyterian Hospital)
"Targeting PI3K in Breast Cancer" |
8:55 pm - 9:15 pm | Discussion
|
9:15 pm - 9:30 pm | General Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | The Mammary Gland Niche and Reprogramming |
9:00 am - 9:10 am | Discussion Leader: Renée van Amerongen (University of Amsterdam)
"Introduction" |
9:10 am - 9:35 am | Zena Werb (University of California San Francisco)
"Regulation of Wnt Signaling in the Mammary Stem Cell Niche"
|
9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Pier Giuseppe Pelicci (European Institute of Oncology)
"Regulation of Self Renewal in Normal and Cancer Mammary Stem Cells"
|
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:25 am | Gil Smith (Center for Cancer Research, National Cancer Institute)
"Gene Products Indispensable to Complete Mammary Development are Dispensable in Reprogramming"
|
11:25 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Mona Shehata (Cancer Research UK - Cambridge Institute)
"Cell Division Kinetics of Mammary Stem and Progenitor Cells" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Aline Wuidart (Interdisciplinary Research Institute (IRIBHM) -ULB)
"No Evidence for Multipotent Stem Cells in the Postnatal Mammary Gland" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Molecular and Cellular Basis of Breast Cancer Risk and Prevention |
6:00 pm - 6:10 pm | Discussion Leader: Victoria Seewaldt (Duke University School of Medicine) "Introduction" |
6:10 pm - 6:35 pm | David Kleinberg (New York University School of Medicine)
"Igf1 in Mammary Development, Hyperplasia and Carcinoma"
|
6:35 pm - 6:50 pm | Discussion |
6:50 pm - 7:15 pm | Coral Alfred Lamartiniere (University of Alabama at Birmingham)
"The Use of Proteomics in Elucidating Mechanisms of Predisposition for Mammary Cancer"
|
7:15 pm - 7:30 pm | Discussion |
7:30 pm - 7:45 pm | Sarah Hein (Baylor College of Medicine)
"Parity Reprograms the Mammary Epithelium to Lower the Apoptotic Anticancer Barrier to Oncogenic Mutations" |
7:45 pm - 7:55 pm | Discussion |
7:55 pm - 8:00 pm | General Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Breast Tumor Heterogeneity and Resistance to Therapy |
9:00 am - 9:10 am | Discussion Leader: Richard Iggo (University of Bordeaux) "Introduction" |
9:10 am - 9:35 am | Kevin P. Roarty (Baylor College of Medicine)
"Wnt Signaling Interactions in the Mammary Epithelium: Developmental Insight into Tumor Heterogeneity" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Jacco Van Rheenen (Hubrecht Institute)
"Intravital Imaging of Tumor Heterogeneity"
|
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:25 am | Matthew Smalley (Cardiff University)
"Mouse Models of Tumor Heterogeneity"
|
11:25 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Hege E. Giercksky Russnes (Oslo University Hospital)
"Impact of Intra-Tumor Heterogeneity on Breast Cancer Response to Therapy"
|
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Maria Vivanco (CIC bioGUNE)
"Tumor Heterogeneity and Tamoxifen Resistance" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Pubertal and Pregnancy Hormones |
6:00 pm - 6:10 pm | Discussion Leader: Rob Clarke (University of Manchester) "Introduction" |
6:10 pm - 6:35 pm | Cathrin Brisken (Ecole Polytechnique Fédérale de Lausanne)
"How Hormones Make the Mammary Gland Blossom"
|
6:35 pm - 6:50 pm | Discussion |
6:50 pm - 7:15 pm | Myles Brown (Dana-Farber Cancer Institute, Harvard Medical School)
"Epigenomics of Hormone Signaling"
|
7:15 pm - 7:30 pm | Discussion |
7:30 pm - 7:45 pm | Heidi Hilton (University of Sydney)
"Steroid Hormone Action in the Normal Human Breast and in Breast Cancer" |
7:45 pm - 7:55 pm | Discussion |
7:55 pm - 8:00 pm | General Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Lactation and Involution |
9:00 am - 9:10 am | Discussion Leader: Caroline Alexander (University of Wisconsin Madison) "Introduction" |
9:10 am - 9:35 am | Katie Hinde (Harvard University)
"Mother's Milk: Evolutionary Perspectives and Cultural Constructs"
|
9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Russ Hovey (University of Davis)
"The Diverse Endocrine Interactions that Contribute to Mammary Function - A Curly Tale"
|
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:25 am | Pepper Schedin (University of Colorado Denver)
"Tissue Remodeling of Postpartum Involution Extends Beyond the Mammary Gland"
|
11:25 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Sharmila Chatterjee (University of California, Santa Cruz)
"ROBO1 and ROBO2 Regulate Mammary Gland Alveologenesis via NOTCH Signaling" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Rachel Zwick (Yale University)
"Mechanisms of Adipocyte Repopulation in the Mammary Gland During Involution" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Tumor Dormancy |
6:00 pm - 6:10 pm | Discussion Leader: Eva Gonzalez Suarez (Bellvitge Biomedical Research Institute) "Introduction" |
6:10 pm - 6:35 pm | Christoph Klein (University of Regensburg)
"Early Dissemination and Metastasis in Breast Cancer: Insights from Mouse Models and Patient-Derived Data"
|
6:35 pm - 6:50 pm | Discussion |
6:50 pm - 7:15 pm | Cyrus M. Ghajar (Fred Hutchinson Cancer Research Center)
"Regulation of Breast Tumor Dormancy by the Perivascular Niche"
|
7:15 pm - 7:30 pm | Discussion |
7:30 pm - 7:45 pm | Colleen Chute (University of Wisconsin-Madison)
"Loss of Host Syndecan-1 Leads to Activation of p38 and Reduced Metastatic Spread in Mice" |
7:45 pm - 7:55 pm | Discussion |
7:55 pm - 8:00 pm | General Discussion |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Metastasis |
9:00 am - 9:10 am | Discussion Leader: Dan Medina (Baylor College of Medicine) "Introduction" |
9:10 am - 9:35 am | Gerhard Christofori (University of Basel)
"Complex Transcriptional Control of EMT, Cancer Stemness and Metastasis"
|
9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Nicola Aceto (Massachusetts General Hospital Cancer Center, Harvard Medical School)
"Identification of Metastatic Precursors Within Circulating Tumor Cells in Breast Cancer Patients"
|
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:25 am | Johanna A. Joyce (Memorial Sloan-Kettering Cancer Center)
"Insights into Organ-Specific Breast Cancer Metastasis from Analysis of Tumor-Stroma Interactions"
|
11:25 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Eva Gonzalez-Suarez (IDIBELL)
"RANK Signaling Controls the Pool of Tumor and Metastasis Initiating Cells" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Laura Jones (McGill)
"Stat3: A Modulator of Immune Surveillance and Metastasis" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Keynote Session: Recurrence and Resistance |
| Discussion Leader: Mohamed Bentires-Alj (Friedrich Miescher Institute for Biomedical Research) |
6:00 pm - 7:10 pm | Nancy Hynes (Friedrich Miescher Institute for Biomedical Research)
"Scientific Travels from MMTV to Human Breast Cancer"
|
7:10 pm - 7:30 pm | Discussion |
7:30 pm - 8:00 pm | Final Comments and Hand Over to the Chairs for 2015 |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |