| Sunday |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Keynote Session: Immune Regulation of Tumor Development |
| Discussion Leader: Caroline Alexander (McArdle Laboratory for Cancer Research, University of Wisconsin, USA) |
| 7:40 pm - 7:55 pm | Opening Remarks |
| 7:55 pm - 8:00 pm | Introduction by Discussion Leader |
| 8:00 pm - 9:00 pm | Bob Schreiber (Washington University in St. Louis School of Medicine, USA)
"Immune Regulation of Tumor Development" |
| 9:00 pm - 9:20 pm | Discussion |
| 9:20 pm - 9:30 pm | General Discussion |
| Monday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Stressing Out: Checkpoints and Instability |
| Discussion Leader: Jeffrey Rosen (Baylor College of Medicine, USA) |
| 9:00 am - 9:10 am | Introduction by Discussion Leader |
| 9:10 am - 9:35 am | Beth Weaver (University of Wisconsin, USA)
"Chromosomal Instability in Breast Cancer" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:15 am | Shridar Ganesan (Rutgers Cancer Institute of New Jersey, USA)
"BRCA Insufficiency and Breast Epithelial Transformation" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:25 am | Alan Diehl (Medical University of South Carolina, USA)
"PERK Signaling in Tumor Initiation and Progression" |
| 11:25 am - 11:40 am | Discussion |
| 11:40 am - 11:55 am | Selected from Poster Abstracts: Elizabeth Kass (Memorial Sloan-Kettering Cancer Center, USA)
"Effect
of BRCA Mutations on Homology-Directed Repair During Mouse Mammary Gland
Development" |
| 11:55 am - 12:05 pm | Discussion |
| 12:05 pm - 12:20 pm | Selected from Poster Abstracts: Jennifer Brancato (Case Western Reserve University, USA)
"BET Inhibitors Induce Growth Arrest in Triple Negative Breast Cancer by Downregulating Aurora Kinases" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Functional Imaging of
the Mammary Gland |
| Discussion Leader: Traci Lyons (University of Colorado, Anschutz Medical Campus, USA) |
| 7:30 pm - 7:40 pm | Introduction by Discussion Leader |
| 7:40 pm - 8:05 pm | Patricia Keely (University of Wisconsin, USA)
"Metabolic Imaging of Tumors and Their Microenvironment" |
| 8:05 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:45 pm | John Condeelis (Albert Einstein College of Medicine, USA)
"Why Breast Tumors Metastasize and How to Stop Them" |
| 8:45 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:15 pm | Selected from Poster Abstracts: Steven Anderson (University of Colorado Anschutz Medical Campus, USA)
"GLUT1 Is Required for Induction of Mammary Tumorigenesis by Activated ErbB2/Her2/Neu" |
| 9:15 pm - 9:30 pm | Discussion |
| Tuesday |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Molecular Risk, Early Detection, and
Prevention of Breast Cancer |
| Discussion Leader: Geoffrey Lindeman (Walter and Eliza Hall Institute / Royal Melbourne Hospital, Australia) |
| 9:00 am - 9:10 am | Introduction by Discussion Leader |
| 9:10 am - 9:35 am | Ginger Borges (University of Colorado, Denver, USA)
"Inflammatory Cells as Susceptibility Factors" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:15 am | Priscilla Furth (Georgetown University, USA)
"Investigating
and Treating Breast Cancer Risk" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:25 am | Elizabeth Repasky (Roswell Park Cancer Institute, USA)
"The
Stress of Feeling Cold Reveals New Relationships Between Anti-Tumor Immunity, Metabolism and Adrenergic Signaling" |
| 11:25 am - 11:40 am | Discussion |
| 11:40 am - 11:55 am | Selected from Poster Abstracts: Fariba Behbod (The University of Kansas Medical Center, USA)
"Expression Profiling of In Vivo Ductal Carcinoma In Situ Progression Models Identify BCL-9 as a Driver of Breast Cancer Invasion" |
| 11:55 am - 12:05 pm | Discussion |
| 12:05 pm - 12:20 pm | Selected from Poster Abstracts: Deborah Lannigan (Vanderblt University, USA)
"RSK2 Controls the Estrogen Receptor Positive Lineage in the Mammary Gland" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Growing Breasts / Signaling Pathways |
| Discussion Leader: John Wysolomerski (Yale University, USA) |
| 7:30 pm - 7:40 pm | Introduction by Discussion Leader |
| 7:40 pm - 8:05 pm | Connie Eaves (British Columbia Cancer Agency, Canada)
"Clonal Tracking of Normal and Malignant Breast Cells In Vivo" |
| 8:05 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:45 pm | Hallgeir Rui (Thomas Jefferson University, USA)
"Modeling Patient-Derived Breast Cancer Xenografts in Prolactin-Humanized Mice" |
| 8:45 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:15 pm | Selected from Poster Abstracts: Sarah Naomi Olsen (Harvard University, USA)
"An Expanding Class of Tumor Suppressors in Breast Cancer" |
| 9:15 pm - 9:30 pm | Discussion |
| Wednesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Adipose Connections |
| Discussion Leader: Terri Wood (Rutgers New Jersey Medical School, USA) |
| 9:00 am - 9:10 am | Introduction by Discussion Leader |
| 9:10 am - 9:35 am | Liza Makowski (University of North Carolina at Chapel Hill, USA)
"Role of the Microenvironment in Obesity-Induced
Basal-Like Breast Cancer" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:15 am | Claudia Fischbach-Tesch (Cornell University, USA)
"Biophysical Considerations of Adipose Tissue and Their Relevance to Breast Cancer" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:25 am | Valerie Horsley (Yale University, USA)
"Dynamic Adipogenesis in the Mammary Gland" |
| 11:25 am - 11:40 am | Discussion |
| 11:40 am - 11:55 am | Selected from Poster Abstracts: Purna Joshi (Princess Margaret Cancer Centre, University Health Network, Canada)
"RANK Controls WNT Signaling for Mammary Progenitor Expansion" |
| 11:55 am - 12:05 pm | Discussion |
| 12:05 pm - 12:20 pm | Selected from Poster Abstracts: Paraic Kenny (Albert Einstein College of Medicine, USA)
"Novel Approaches to Target Amphiregulin: A Key Mediator of Estrogen Action in Breast Cancer" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Mammary Circulatory Systems and Metastasis |
| Discussion Leader: Cyrus Ghajar (Fred Hutchinson Cancer Research Center, USA) |
| 7:30 pm - 7:40 pm | Introduction by Discussion Leader |
| 7:40 pm - 8:05 pm | Heide Ford (University of Colorado, Anschutz Medical Campus, USA)
"The
Six1/Eya Transcriptional Complex Modulates the Immune and Lymphatic Microenvironment to Stimulate Breast Cancer Metastasis" |
| 8:05 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:45 pm | William Muller (McGill University, Canada)
"Stat3 Promotes Immune Evasion and Metastasis in PyMT-Driven Mammary Tumorigenesis" |
| 8:45 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:15 pm | Selected from Poster Abstracts: Traci Lyons (University of Colorado, Anschutz Medical Campus, USA)
"Mammary Macrophages, Lymphangiogenesis, and COX-2" |
| 9:15 pm - 9:30 pm | Discussion |
| Thursday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Metabolism and Epigenetic Regulation of
Development and Tumorigenesis |
| Discussion Leader: Steffi Oesterreich (University of Pittsburgh Cancer Institute, USA) |
| 9:00 am - 9:10 am | Introduction by Discussion Leader |
| 9:10 am - 9:35 am | Leslie Shaw (University of Massachusetts Medical School, USA)
"Regulation
of Growth Factor Receptor Signaling by Beclin 1" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:15 am | Richard Cerione (Cornell University, USA)
"Glutamine Dependence in Breast Epithelial Cells" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:25 am | Jayanta Debnath (University of California, San Francisco, USA)
"How
and Where to Effectively Target Autophagy Against Breast Cancer" |
| 11:25 am - 11:40 am | Discussion |
| 11:40 am - 11:55 am | Selected from Poster Abstracts: Scott Pearson (Texas A&M University, USA)
"Regulation of Senescence-Metabolic Equilibrium by SIM2s in DCIS Progression" |
| 11:55 am - 12:05 pm | Discussion |
| 12:05 pm - 12:20 pm | Selected from Poster Abstracts: Eran Andrechek (Michigan State University, USA)
"E2F2 Mediated Copy Number Changes Lead to Increased Tumor Metastasis in HER2+ Breast Cancer Patients" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Session: Modeling Breast Development and Tumorigenesis |
| Discussion Leader: William Muller (McGill University, Canada) |
| 7:30 pm - 7:40 pm | Introduction by Discussion Leader |
| 7:40 pm - 8:40 pm | Robert Cardiff (University of California, Davis, USA)
"What Mice Have Taught Us About Breast Cancer" |
| 8:40 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | General Discussion |
| 9:20 pm - 9:30 pm | Closing Remarks |
| Friday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
