Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: The Mammary Gland Genome in Development and Cancer |
| Discussion Leader: Geoffrey Lindeman (Walter and Eliza Hall Institute / Royal Melbourne Hospital, Australia) |
7:40 pm - 7:55 pm | Opening Remarks |
7:55 pm - 8:05 pm | Introduction by Discussion Leader |
8:05 pm - 9:05 pm | Charles Perou (University of North Carolina at Chapel Hill, USA) "The Mammary Gland Genome in Development and Cancer" |
9:05 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Making a Mammary Gland - Stem Cells and Development |
| Discussion Leader: Silvia Fre (Institut Curie, France) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:35 am | Geoffrey Wahl (The Salk Institute, USA) "Insights into Breast Cancer Gained from a Developmental
Approach" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Jane Visvader (The Walter and Eliza Hall Institute of Medical Research, Australia) "Exploiting the Epithelial Hierarchy to Understand Breast Cancer" |
10:15 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 11:20 am | Lindsay Hinck (University of California, Santa Cruz, USA) "The Role of SLIT/ROBO Signaling in Mammary Stem
Cell Self-Renewal" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Renee Van Amerongen (University of Amsterdam, The Netherlands) "Dissecting the Role of Wnt Signalling in Mammary Gland Development and Breast Cancer" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Selected from Poster Abstracts: Veronica Rodilla (Vall d'Hebron Institute of Oncology, Spain) "Lineage Tracing in the Developing Mouse Mammary Gland Reveals that Notch1 Is Essential for Cell Fate Commitment" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Regulators of Functional Maturation and Regression
in the Mammary Gland |
| Discussion Leader: Kay-Uwe Wagner (University of Nebraska Medical Center, USA) |
6:00 pm - 6:15 pm | Introduction by Discussion Leader |
6:15 pm - 6:40 pm | Christine Watson (University of Cambridge, United Kingdom) "The Role of Stat3 in Cell Fate Decisions in the Mammary Gland" |
6:40 pm - 6:55 pm | Discussion |
6:55 pm - 7:20 pm | Christina Scheel (Helmholtz Center Munich, Germany) "Modeling Epithelial Plasticity in Human Mammary Gland
Regeneration and Tumor Progression" |
7:20 pm - 7:35 pm | Discussion |
7:35 pm - 7:50 pm | Selected from Poster Abstracts: Anne Rios (Walter and Eliza Hall Institute of Medical Research, Australia) "Essential Role for a Novel Population of Binucleated Mammary Epithelial Cells in Lactation" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Hormonal Cues and Connections: Clues for Treatment and Prevention |
| Discussion Leader: Cathrin Brisken (Ecole Polytechnique Federale de Lausanne, Switzerland) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:35 am | Wayne Tilley (University of Adelaide / Hanson Institute, Australia) "Steroid Receptor Cross Talk in Breast Cancer: Molecular Insights and Therapeutic Implications" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Robert Clarke (University of Manchester, United Kingdom) "Signalling and Cellular Phenotypes in ER+
Breast Cancer After Endocrine Therapies" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Steffi Oesterreich (University of Pittsburgh Cancer Institute, USA) "Estrogen Receptor Mutations in Endocrine Resistant Breast
Cancer Metastases" |
11:25 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Selected from Poster Abstracts: Jennifer Richer (University of Colorado Anschutz Medical Campus, USA) "Androgen Receptor (AR) Supports a Tumor Initiating Population in AR+ Triple-Negative Breast Cancer (TNBC)" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Selected from Poster Abstracts: Georgios Sflomos (École Polytechnique Fédérale de Lausanne, Switzerland) "A Preclinical Model for ERα Positive Breast Cancer Reveals the Mammary Epithelial Microenvironment as a Determinant of the Luminal Phenotype and Hormone Response" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | BRCA1 and Beyond – Two Decades On |
| Discussion Leader: Connie Eaves (British Columbia Cancer Agency, Canada) |
6:00 pm - 6:15 pm | Introduction by Discussion Leader |
6:15 pm - 6:40 pm | Jos Jonkers (Netherlands Cancer Institute, The Netherlands) "Genetic Determinants of Therapy Response and Resistance in Mouse Models of BRCA-Deficient Breast Cancer" |
6:40 pm - 6:55 pm | Discussion |
6:55 pm - 7:20 pm | Matthew Smalley (European Cancer Stem Cell Research Institute, United Kingdom) "Lyn Kinase and Brca1: Key Partners in Cell Survival" |
7:20 pm - 7:35 pm | Discussion |
7:35 pm - 7:50 pm | Selected from Poster Abstracts: Alex Swarbrick (Garvan Institute of Medical Research, Australia) "New Insights into the Transcriptional Networks Governing Mammary Stem Cell Homeostasis and Basal-Like Breast Cancer Aetiology" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Normal Development Gone Awry - Mouse Mammary Tumor Models |
| Discussion Leader: Michael Lewis (Baylor College of Medicine, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:35 am | Mohamed Bentires-Alj (Friedrich Miescher Institute for Biomedical Research, Switzerland) "Breast Tumor Heterogeneity: Source of Fitness, Hurdle for Therapy" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Christopher Ormandy (Garvan Institute of Medical Research, Australia) "Elf5, a Developmental Regulator that Provides a Path
for Breast Cancer Progression" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Barry Gusterson (Glasgow University, United Kingdom) "A Critical Analysis of GEM Models of Human Breast Cancer - A Human Pathologist's View" |
11:25 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Selected from Poster Abstracts: Susan Farabaugh (University of Pittsburgh, USA) "Oncogene Induced Changes in Mammary Differentiation and Cell Fate in Breast Tumorigenesis" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Selected from Poster Abstracts: Sjors Kas (Netherlands Cancer Institute, The Netherlands) "In Vivo Insertional Mutagenesis to Discover Novel Tumor Promoting Genes of Invasive Lobular Carcinoma" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Mammary Tumor Heterogeneity, Dormancy and Metastasis |
| Discussion Leader: Maria Vivanco (CIC bioGUNE, Spain) |
6:00 pm - 6:15 pm | Introduction by Discussion Leader |
6:15 pm - 6:40 pm | Salvatore Pece (IEO - European Institute of Oncology, Italy) "Connecting the Machineries of Cell Fate Determination and Tumor Suppression in Mammary Cancer Stem Cells" |
6:40 pm - 6:55 pm | Discussion |
6:55 pm - 7:20 pm | Peter Eirew (BC Cancer Agency, Canada) "Intratumoural Genomic Heterogeneity and Clonal Dynamics in Breast Cancer Xenograft Models" |
7:20 pm - 7:35 pm | Discussion |
7:35 pm - 7:50 pm | Selected from Poster Abstracts: Alyssa Johnston (Baylor College of Medicine, USA) "Neuroleptics and Breast Cancer Risk" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Growth and Inhibitory Signals – Epithelial and Stromal Cues |
| Discussion Leader: Heide Ford (University of Colorado Anschutz Medical Campus, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:35 am | Marja Mikkola (University of Helsinki, Finland) "Embryonic Mammary Gland Branching Morphogenesis" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Martin Eilers (Biozentrum der Universitat Wurzburg, Germany) "Myc as a Key Driver of Mitrochondrial Dynamics in Mammary Epithelium and Cancer" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Mary Helen Barcellos-Hoff (University of California, San Francisco, USA) "Systemic Biology Mediates Breast Cancer Intrinsic Subtype" |
11:25 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Selected from Poster Abstracts: Peter Kabos (University of Colorado Anschutz Medical Campus, USA) "Cancer Associated Fibroblasts Regulate Estrogen Receptor Expression, Treatment Response and Metastatic Potential of Luminal Breast Cancer Cells" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Selected from Poster Abstracts: Spencer Watson (Oregon Health and Science University, USA) "Phenotypic Subtypes of HER2+ Breast Cancer Rescued from Lapatinib by Discrete Microenvironment Factors" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Keynote Session: Modeling Mammary Gland Development and Cancer |
| Discussion Leader: Nancy Hynes (Friedrich Miescher Institute, Switzerland) |
6:00 pm - 6:10 pm | Introduction by Discussion Leader |
6:10 pm - 7:10 pm | Lothar Hennighausen (National Institutes of Health, USA) "La Bellezza del Genoma Mammario" |
7:10 pm - 7:30 pm | Discussion |
7:30 pm - 7:50 pm | General Discussion |
7:50 pm - 8:00 pm | Closing Remarks |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |