Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Niches in Development and Disease
Discussion Leader: Heather Machado (Tulane University School of Medicine, USA)
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:10 pm
Introduction by Discussion Leader
8:10 pm - 9:10 pm
Adrian Harris (University of Oxford, United Kingdom)
"Hypoxia, Stem Cells, and Survival"
9:10 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Identity, Regulation and Therapeutic Targeting of
Stem Cells
Discussion Leader: Carol Sartorius (University of Colorado Anschutz Medical Campus, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Tannishtha Reya (University of California, San Diego, USA)
"Stem Cell Signals in Cancer Heterogeneity and Therapy Resistance"
9:35 am - 9:50 am
Discussion
9:50 am - 10:15 am
Sridhar Ramaswamy (Massachusetts General Hospital / Harvard Medical School, USA)
"Targeting Sleeping Cancer Cells"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Paul Macklin (Intelligent Systems Engineering, Indiana University, USA)
"3-D Simulations of Multicellular Systems Biology in Ductal Carcinoma In Situ "
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
Max Wicha (University of Michigan Medical Center, USA)
"Identification and Targeting Stem Cell Regulatory
Pathways"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Gilbert Smith (Center for Cancer Research, National Cancer Institute, NIH, USA)
"Mammary 'ECM' and Induction of Mammary Development by Non-Mammary Cells: Significance to Multipotent vs Unipotent Mammary Progenitor/Stem Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Joan Brugge (Harvard Medical School, USA) and Tannishtha Reya (University of California, San Diego, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stromal Determinants of Epithelial Cell Behavior
Discussion Leader: Renee Van Amerongen (University of Amsterdam, The Netherlands)
7:30 pm - 7:40 pm
Introduction by Discussion Leader: Stromal Determinants of Epithelial Cell Behavior
7:40 pm - 8:05 pm
Kaylee Schwertfeger (University of Minnesota, USA)
"Regulation of Mammary Gland Development and Tumorigenesis by Macrophage-Directed Epithelial"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Valerie Weaver (University of California, San Francisco, USA)
"Matrix Stiffness and Tumor Development"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Selected from Poster Abstracts: Lin Ma (University of California, San Francisco, USA)
"Ionizing Radiation Promotes Aggressive Tumors that Exhibit Increased Immune Suppression"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Selected from Poster Abstracts: Adam Watson (University of Arizona Cancer Center, USA)
"Primary Breast Tumor Stiffness Instructs Osteotropic Metastasis via Mechanical Memory"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Heterogeneity in Development and Disease
Discussion Leader: Mohamed Bentires-Alj (University of Basel / University Hospital Basel, Switzerland)
9:00 am - 9:15 am
Introduction by Discussion Leader: Heterogeneity in Development and Disease
9:15 am - 9:40 am
Joan Brugge (Harvard Medical School, USA)
"Tracking Functional Heterogeneity and Intratumoral Crosstalk of Triple Negative Breast Cancer Cells"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
Ann Ramsdell (University of South Carolina, USA)
"Breast Cancer Heterogeneity, Axial Patterning, and
the Mammary Microenvironment"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Mei Zhang (University of Pittsburgh, USA)
"Clonal Cooperativity in Tumor Development"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Devon Lawson (University of California, Irvine, USA)
"Investigation of Intratumor Heterogeneity in Cancer Progression and Metastasis at the Single-Cell Level"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Sai Mun Leong (National University of Singapore, Singapore)
"Regenerable Altruism Drives Chemotolerance in Clonal Cancer Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mammary Epithelial Cell Plasticity
Discussion Leader: Sendurai Mani (University of Texas MD Anderson Cancer Center, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader: Mammary Epithelial Cell Plasticity
7:40 pm - 8:05 pm
Robert Weinberg (Whitehead Institute for Biomedical Research, USA)
"Molecular Regulation of Tumor-Initiating Cell
Plasticity"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Kornelia Polyak (Dana-Farber Cancer Institute, USA)
"Breast Cancer Risk Prediction and Prevention"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Selected from Poster Abstracts: Jerrica Breindel (Tufts University, USA)
"Epigenetic Mechanisms of Primary Human Mammary Epithelial Cell Dedifferentiation"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Selected from Poster Abstracts: Zhe Li (Brigham and Women's Hospital, USA)
"BRCA1-Loss Triggers Alteration in the Fates of ER+ and ER- Mammary Luminal Cells"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lactation Biology
Discussion Leader: James McManaman (University of Colorado School of Medicine, USA)
9:00 am - 9:15 am
Introduction by Discussion Leader: Lactation Biology
9:15 am - 9:40 am
Darryl Hadsell (Baylor College of Medicine, USA)
"Lessons About Mammary Development and Lactation from Diverse Inbred Mouse Strains"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
Malcolm Kennedy (University of Glasgow, United Kingdom)
"The Multifarious Lactation Strategies of Mammals"
10:20 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Weston Porter (Texas A&M University, USA)
"Metabolic Adaptation in Lactation: A Model for Breast Cancer Progression?"
11:30 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Selected from Poster Abstracts: Jenifer Monks (University of Colorado Anschutz Medical Campus, USA)
"Cell Biology of Lactation: Docking and Stimulated Secretion of Milk Fat Globules"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Rajeev Samant (University of Alabama at Birmingham, USA)
"Errors in Developmental Programming Increase Susceptibility to Metastasis"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion: Lactation Biology
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cellular Dormancy in Development, Treatment
Resistance, and Recurrence
Discussion Leader: Pepper Schedin (Oregon Health and Science University, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader: Cellular Dormancy in Development, Treatment Resistance, and Recurrence
7:40 pm - 8:05 pm
Lewis Chodosh (University of Pennsylvania, USA)
"Tumor Dormancy as a Window to Prevent Metastatic Recurrence"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Senthil Muthuswamy (Beth Israel Deaconess Medical Center / Harvard Medical School, USA)
"Cell Polarity Proteins and Cell Surface Proteome –
Impact on Mammary Gland Development and Cancer"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Selected from Poster Abstracts: Kristina Havas (IFOM - The FIRC Institute of Molecular Oncology, Italy)
"Metabolic Shifts in Residual Breast Cancer Drive Tumor Recurrence"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Selected from Poster Abstracts: Delphine Merino (Olivia Newton-John Cancer Research Institute, Australia)
"Tracking and Targeting Aggressive Clones in Metastatic Triple Negative Breast Cancer"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Unconventional Mechanisms Controlling Organogenesis
and Carcinogenesis
Discussion Leader: Sean Egan (Hospital for Sick Children, Canada)
9:00 am - 9:15 am
Introduction by Discussion Leader: Unconventional Mechanisms Controlling Organogenesis and Carcinogenesis
9:15 am - 9:40 am
Sol Fereres-Rapoport (University of California, San Francisco, USA)
"Paracrine Signaling in Development and Disease"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
Benny Kaipparettu (Baylor College of Medicine, USA)
"Dominance of Mitochondria over the Malignant Phenotype"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
David Spector (Cold Spring Harbor Laboratory, USA)
"Long Non-Coding RNAs as Targets in Mammary Cancer Progression"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Mikala Egeblad (Cold Spring Harbor Laboratory, USA)
"Neutrophil Extracellular Traps Promote Breast Cancer Metastasis and Escape from Dormancy"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts: Gat Rauner (Cornell University, USA)
"Unraveling the Mechanisms Behind Species-Resistance to Mammary Cancer"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Future Directions in Mammary Gland Research
Discussion Leader: Robert Clarke (University of Manchester, United Kingdom)
7:30 pm - 7:45 pm
Introduction by Discussion Leader: Future Directions in Mammary Gland Research
7:45 pm - 8:45 pm
Ian Macara (Vanderbilt University Medical Center, USA)
"Mammary Development, Cancer, and Epithelial Homeostasis"
8:45 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
General Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure