Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Niches in Development and Disease
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:10 pm
Introduction by Discussion Leader
8:10 pm - 9:10 pm
"Hypoxia, Stem Cells, and Survival"
9:10 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Identity, Regulation and Therapeutic Targeting of
Stem Cells
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Stem Cell Signals in Cancer Heterogeneity and Therapy Resistance"
9:35 am - 9:50 am
Discussion
9:50 am - 10:15 am
"Targeting Sleeping Cancer Cells"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"3-D Simulations of Multicellular Systems Biology in Ductal Carcinoma In Situ "
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Identification and Targeting Stem Cell Regulatory
Pathways"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Mammary 'ECM' and Induction of Mammary Development by Non-Mammary Cells: Significance to Multipotent vs Unipotent Mammary Progenitor/Stem Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stromal Determinants of Epithelial Cell Behavior
7:30 pm - 7:40 pm
Introduction by Discussion Leader: Stromal Determinants of Epithelial Cell Behavior
7:40 pm - 8:05 pm
"Regulation of Mammary Gland Development and Tumorigenesis by Macrophage-Directed Epithelial"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Matrix Stiffness and Tumor Development"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Ionizing Radiation Promotes Aggressive Tumors that Exhibit Increased Immune Suppression"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Primary Breast Tumor Stiffness Instructs Osteotropic Metastasis via Mechanical Memory"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Heterogeneity in Development and Disease
9:00 am - 9:15 am
Introduction by Discussion Leader: Heterogeneity in Development and Disease
9:15 am - 9:40 am
"Tracking Functional Heterogeneity and Intratumoral Crosstalk of Triple Negative Breast Cancer Cells"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Breast Cancer Heterogeneity, Axial Patterning, and
the Mammary Microenvironment"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Clonal Cooperativity in Tumor Development"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Investigation of Intratumor Heterogeneity in Cancer Progression and Metastasis at the Single-Cell Level"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Regenerable Altruism Drives Chemotolerance in Clonal Cancer Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mammary Epithelial Cell Plasticity
7:30 pm - 7:40 pm
Introduction by Discussion Leader: Mammary Epithelial Cell Plasticity
7:40 pm - 8:05 pm
"Molecular Regulation of Tumor-Initiating Cell
Plasticity"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Breast Cancer Risk Prediction and Prevention"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Epigenetic Mechanisms of Primary Human Mammary Epithelial Cell Dedifferentiation"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"BRCA1-Loss Triggers Alteration in the Fates of ER+ and ER- Mammary Luminal Cells"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:15 am
Introduction by Discussion Leader: Lactation Biology
9:15 am - 9:40 am
"Lessons About Mammary Development and Lactation from Diverse Inbred Mouse Strains"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
"The Multifarious Lactation Strategies of Mammals"
10:20 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Metabolic Adaptation in Lactation: A Model for Breast Cancer Progression?"
11:30 am - 11:45 am
Discussion
11:45 am - 12:00 pm
"Cell Biology of Lactation: Docking and Stimulated Secretion of Milk Fat Globules"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Errors in Developmental Programming Increase Susceptibility to Metastasis"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion: Lactation Biology
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cellular Dormancy in Development, Treatment
Resistance, and Recurrence
7:30 pm - 7:40 pm
Introduction by Discussion Leader: Cellular Dormancy in Development, Treatment Resistance, and Recurrence
7:40 pm - 8:05 pm
"Tumor Dormancy as a Window to Prevent Metastatic Recurrence"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Cell Polarity Proteins and Cell Surface Proteome –
Impact on Mammary Gland Development and Cancer"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Metabolic Shifts in Residual Breast Cancer Drive Tumor Recurrence"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Tracking and Targeting Aggressive Clones in Metastatic Triple Negative Breast Cancer"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Unconventional Mechanisms Controlling Organogenesis
and Carcinogenesis
9:00 am - 9:15 am
Introduction by Discussion Leader: Unconventional Mechanisms Controlling Organogenesis and Carcinogenesis
9:15 am - 9:40 am
"Paracrine Signaling in Development and Disease"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Dominance of Mitochondria over the Malignant Phenotype"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Long Non-Coding RNAs as Targets in Mammary Cancer Progression"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Neutrophil Extracellular Traps Promote Breast Cancer Metastasis and Escape from Dormancy"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Unraveling the Mechanisms Behind Species-Resistance to Mammary Cancer"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Future Directions in Mammary Gland Research
7:30 pm - 7:45 pm
Introduction by Discussion Leader: Future Directions in Mammary Gland Research
7:45 pm - 8:45 pm
"Mammary Development, Cancer, and Epithelial Homeostasis"
8:45 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
General Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure