Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Establishing Complex Tissue Architecture by Integrating Mechanical and Biochemical Cues
Discussion Leaders: Renee Van Amerongen (University of Amsterdam, The Netherlands) and Christina Scheel (Helmholtz Center Munich, Germany)
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:05 pm
Introduction by Discussion Leader
8:05 pm - 9:05 pm
Celeste Nelson (Princeton University, USA)
"Establishing Complex Tissue Architecture by Integrating Mechanical and Biochemical Cues"
9:05 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Transcriptional and Translational Control of Mammary Gland Development and Breast Cancer
Discussion Leader: Maria Vivanco (CIC bioGUNE, Spain)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Andrew Ewald (Johns Hopkins University, USA)
"Molecular Programs of Epithelial Motility During Branching Morphogenesis and Cancer Invasion"
9:35 am - 9:50 am
Discussion
9:50 am - 10:15 am
Camila dos Santos (Cold Spring Harbor Laboratory, USA)
"The Effects of Pregnancy on Gene Regulation, Development and Cancer"
10:15 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Clare Davies (University of Birmingham, United Kingdom)
"Linking Arginine Methylation with the Epigenetic Regulation of Breast Cancer Stem Cells: New Therapeutic Opportunities?"
11:20 am - 11:35 am
Discussion
11:35 am - 11:50 am
Selected from Poster Abstracts: Mona Shehata (Medical Research Council Cancer Unit, United Kingdom)
"Proliferative Heterogeneity of Mammary Epithelial Cells"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Maria Vivanco (CIC bioGUNE, Spain)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Emerging Aspects of Metastasis
Discussion Leader: Eva Gonzalez-Suarez (Bellvitge Biomedical Research Institute (IDIBELL), Spain)
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:40 pm
Nicola Aceto (University of Basel, Switzerland)
"Targeting Vulnerabilities of Circulating Tumor Cell Clusters"
6:40 pm - 6:55 pm
Discussion
6:55 pm - 7:20 pm
Khalil Zaman (Centre Hospitalier Universitaire Vaudois (CHUV), Switzerland)
"Immunotherapy in Breast Cancer, Current Clinical Data and New Perspectives"
7:20 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
Selected from Poster Abstracts: Gray Pearson (Georgetown University, USA)
"Defining How Cooperative Interactions Between Tumor Subpopulations Promote Metastasis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mammary Gland Biology Beyond Mice and Women
Discussion Leader: Russell Hovey (University of California, Davis, USA)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
Dagmar Iber (ETH Zurich, Switzerland)
"From Networks to Function – Computational Models of Organogenesis"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
Kathleen Arcaro (University of Massachusetts Amherst, USA)
"Biomarkers of Breast Cancer Risk in Breastmilk: Inflammation, Methylation and Mutations"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Patrick Humbert (La Trobe Institute for Molecular Science, La Trobe University, Australia)
"Identifying Tumourigenesis Pathways and Anti-Cancer Compounds Relevant to Human Breast Cancer Using the Drosophila Model Organism"
11:25 am - 11:40 am
Discussion
11:40 am - 11:55 am
Selected from Poster Abstracts: Ben Atwell (University of Arizona, USA)
"Targeting Sorting Nexins to Treat ERBB-Dependent Breast Cancer"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Selected from Poster Abstracts: Stacey Aggarwal (University of Washington, USA)
"Powerhouse of the Breast Cancer Cell: How Regulation of dAKAP1 Expression Influences Cell Motility via Changes in Mitochondrial Dynamics"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Breast Cancer Heterogeneity and Precision Medicine
Discussion Leader: Tan Ince (University of Miami, USA)
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:40 pm
Nicholas Navin (University of Texas MD Anderson Cancer Center, USA)
"Delineating Normal Breast Biology and Cancer with Single Cell Genomics"
6:40 pm - 6:55 pm
Discussion
6:55 pm - 7:20 pm
Christoph Klein (University of Regensburg, Germany)
"Mechanisms of Early Dissemination and Metastasis Formation"
7:20 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
Selected from Poster Abstracts: Johanna Wagner (University of Zurich, Switzerland)
"Single Cell Atlas of Tumor and Immune Cell Heterogeneity in Human Breast Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Physiological and Environmental Factors that Influence Lactation and Breast Cancer Risk
Discussion Leader: Robert Clarke (University of Manchester, United Kingdom)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
Xavier Trepat (Institute for Bioengineering of Catalonia (IBEC), Spain)
"Mechanobiology of Epithelial Growth and Folding"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
Rebecca Riggins (Georgetown University, USA)
"ER Rewired: Receptor Signaling in Therapy Resistant and Invasive Lobular Breast Cancer"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Donna Geddes (University of Western Australia, Australia)
"Causes of Dysfunction in the Lactating Mammary Gland"
11:25 am - 11:40 am
Discussion
11:40 am - 11:55 am
Selected from Poster Abstracts: Olivia McGinn (University of Colorado Anschutz Medical Campus, USA)
"Cytokeratin 5/Beta-Catenin Interaction and Crosstalk in Maintaining Breast Cancer Stem Cells"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Selected from Poster Abstracts: Jonathan Rennhack (Michigan State University, USA)
"Genomic Alterations Impact Metastatic Potential and Oncogenic Signaling of Mouse Models of Breast Cancer"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
(Immune) System Interactions in Development and Disease
Discussion Leader: Kaylee Schwertfeger (University of Minnesota, USA)
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:40 pm
Jennifer Richer (University of Colorado Anschutz Medical Campus, USA)
"Breast Cancer Highjacks a Developmental Program of Immune Suppression: Hormonal and Inflammatory Mediators"
6:40 pm - 6:55 pm
Discussion
6:55 pm - 7:20 pm
Geoffrey Lindeman (Walter and Eliza Hall Institute of Medical Research, Australia)
"Targeting Pro-Survival Signaling – Exposing an Achilles’ Heel in Breast Cancer?"
7:20 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
Selected from Poster Abstracts: Heide Ford (University of Colorado Anschutz Medical Campus, USA)
"A Novel Eya3/Myc/PD-L1 Axis Drives TNBC Progression via Regulation of CD8+ T-Cell Exhaustion"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Developmental Signaling and Tumor Resistance Mechanisms
Discussion Leader: Weston Porter (Texas A&M University, USA)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
Thorarinn Gudjonnson (University of Iceland, Iceland)
"Exploring Cooperation of microRNAs and codingRNAs in Branching Breast Morphogenesis and EMT"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
Benjamin Spike (Huntsman Cancer Institute, University of Utah, USA)
"Resolving Stem Cell State Changes in the Developing Mouse Mammary Gland"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Johanna Ivaska (University of Turku, Finland)
"Mechanosensing and Endosomal Traffic in Mammary Gland Development and Cancer"
11:25 am - 11:40 am
Discussion
11:40 am - 11:55 am
Selected from Poster Abstracts: Silvia Fre (Institut Curie, France)
"Clonal Analysis of Notch1-Expressing Cells Reveals the Existence of Unipotent Stem Cells that Retain Long-Term Plasticity in the Embryonic Mammary Gland"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Selected from Poster Abstracts: Lindsey Seldin (Vanderbilt University, USA)
"Mammary Myoepithelial Cells Respond to Damage by Altering Cell Fate In Vivo "
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Fate, Potential and Lineage Commitment of Mammary Gland Stem Cells
Discussion Leader: Mohamed Bentires-Alj (University of Basel / University Hospital Basel, Switzerland)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 7:10 pm
Cedric Blanpain (Universite Libre de Bruxelles, Belgium)
"Fate, Potential and Lineage Commitment of Mammary Gland Stem Cells"
7:10 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
General Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure