Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Establishing Complex Tissue Architecture by Integrating Mechanical and Biochemical Cues
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:05 pm
Introduction by Discussion Leader
8:05 pm - 9:05 pm
"Establishing Complex Tissue Architecture by Integrating Mechanical and Biochemical Cues"
9:05 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Transcriptional and Translational Control of Mammary Gland Development and Breast Cancer
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Molecular Programs of Epithelial Motility During Branching Morphogenesis and Cancer Invasion"
9:35 am - 9:50 am
Discussion
9:50 am - 10:15 am
"The Effects of Pregnancy on Gene Regulation, Development and Cancer"
10:15 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Linking Arginine Methylation with the Epigenetic Regulation of Breast Cancer Stem Cells: New Therapeutic Opportunities?"
11:20 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Proliferative Heterogeneity of Mammary Epithelial Cells"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Emerging Aspects of Metastasis
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:40 pm
"Targeting Vulnerabilities of Circulating Tumor Cell Clusters"
6:40 pm - 6:55 pm
Discussion
6:55 pm - 7:20 pm
"Immunotherapy in Breast Cancer, Current Clinical Data and New Perspectives"
7:20 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
"Defining How Cooperative Interactions Between Tumor Subpopulations Promote Metastasis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mammary Gland Biology Beyond Mice and Women
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
"From Networks to Function – Computational Models of Organogenesis"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Biomarkers of Breast Cancer Risk in Breastmilk: Inflammation, Methylation and Mutations"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Identifying Tumourigenesis Pathways and Anti-Cancer Compounds Relevant to Human Breast Cancer Using the Drosophila Model Organism"
11:25 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Targeting Sorting Nexins to Treat ERBB-Dependent Breast Cancer"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Powerhouse of the Breast Cancer Cell: How Regulation of dAKAP1 Expression Influences Cell Motility via Changes in Mitochondrial Dynamics"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Breast Cancer Heterogeneity and Precision Medicine
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:40 pm
"Delineating Normal Breast Biology and Cancer with Single Cell Genomics"
6:40 pm - 6:55 pm
Discussion
6:55 pm - 7:20 pm
"Mechanisms of Early Dissemination and Metastasis Formation"
7:20 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
"Single Cell Atlas of Tumor and Immune Cell Heterogeneity in Human Breast Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Physiological and Environmental Factors that Influence Lactation and Breast Cancer Risk
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
"Mechanobiology of Epithelial Growth and Folding"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
"ER Rewired: Receptor Signaling in Therapy Resistant and Invasive Lobular Breast Cancer"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Causes of Dysfunction in the Lactating Mammary Gland"
11:25 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Cytokeratin 5/Beta-Catenin Interaction and Crosstalk in Maintaining Breast Cancer Stem Cells"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Genomic Alterations Impact Metastatic Potential and Oncogenic Signaling of Mouse Models of Breast Cancer"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
(Immune) System Interactions in Development and Disease
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:40 pm
"Breast Cancer Highjacks a Developmental Program of Immune Suppression: Hormonal and Inflammatory Mediators"
6:40 pm - 6:55 pm
Discussion
6:55 pm - 7:20 pm
"Targeting Pro-Survival Signaling – Exposing an Achilles’ Heel in Breast Cancer?"
7:20 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
"A Novel Eya3/Myc/PD-L1 Axis Drives TNBC Progression via Regulation of CD8+ T-Cell Exhaustion"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Developmental Signaling and Tumor Resistance Mechanisms
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
"Exploring Cooperation of microRNAs and codingRNAs in Branching Breast Morphogenesis and EMT"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Resolving Stem Cell State Changes in the Developing Mouse Mammary Gland"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Mechanosensing and Endosomal Traffic in Mammary Gland Development and Cancer"
11:25 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Clonal Analysis of Notch1-Expressing Cells Reveals the Existence of Unipotent Stem Cells that Retain Long-Term Plasticity in the Embryonic Mammary Gland"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Mammary Myoepithelial Cells Respond to Damage by Altering Cell Fate In Vivo "
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Fate, Potential and Lineage Commitment of Mammary Gland Stem Cells
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 7:10 pm
"Fate, Potential and Lineage Commitment of Mammary Gland Stem Cells"
7:10 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
General Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure