Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Interactions Between the Mammary Epithelium and its Environment Under Physiological and Pathological Conditions
Discussion Leader: Nomeda Girnius (Harvard Medical School, United States)
3:15 pm - 3:20 pm
Introduction by Discussion Leader
3:20 pm - 3:35 pm
Sherif Attalla (Goodman Cancer Institute, McGill University, Canada)
"Regulation of the TIME and Stemness by ENPP1 in Breast Cancer"
3:35 pm - 3:40 pm
Discussion
3:40 pm - 3:55 pm
Simon Castillo (The Institute of Cancer Research, United Kingdom)
"A Deep Learning-Boosted Search of Early Warnings of DCIS Recurrence Scrutinising Duct Morphology and Spatial Immune Ecology"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Processes Driving Normal Mammary Gland Development and Breast Cancer Progression
Discussion Leader: Maryknoll Linscott (Pennsylvania State College of Medicine, United States)
5:30 pm - 5:45 pm
Alex Pfannenstein (Vanderbilt University, United States)
"Cellular Intercalation Regulates Mammary Epithelium Development And Organization"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Alejandro Collado (Spanish National Cancer Research Centre (CNIO), Madrid, Spain, Spain)
"Loss of Luminal RANK Signaling Leads to Basal Stem Cell Bipotency in Post Pregnancy Mammary Glands"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
G. Kenneth Gray (Harvard Medical School, United States)
"A Postnatal Murine Mammary Epithelial Atlas Revealing Hormonal Control of Epithelial Diversity and Lineage Fidelity and Delineating Cyclic Differentiation Processes"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Camille Landragin (Institut Curie, France)
"Luminal Progenitor Cells Escape Genomic Crisis through Epithelial-to-Mesenchymal Transition during Brca1-tumorigenesis"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Jackson Liang (Genentech, United States)
"Giredestrant Counters a Progesterone Hypersensitivity Program Driven by Estrogen Receptor Mutations in Breast Cancer"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Novel Tools and Approaches for the Study of Mammary Gland Development, Tumor Progression and for Breast Cancer Treatment
Discussion Leader: Yu Gu (McGill University - Rosalind and Morris Goodman Cancer Institute, Canada)
9:00 am - 9:15 am
Alessia Morato (University of California, Davis, United States)
"Untangling the Interactions between ErbB Receptors and their Ligands in the Porcine Mammary Gland as a Model for Breast Morphogenesis."
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Matthew Waas (Princess Margaret Cancer Centre, University Health Network, Canada)
"Proteomic Phenotyping of a Metabolically Defined Putative Mammary Gland Stem Cell Population"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Joseph Parsons (University of Manchester, United Kingdom)
"Proteomics Identifies Osteomodulin as a Predictive Biomarker in Breast Cancer Bone Metastasis and a Driver of Breast Cancer Cell Migration"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Ashley Ward (University of Colorado, Anschutz Medical Campus, United States)
"Endocrine Resistant Breast Cancer Cells Display Adaptive Changes in Lipid Metabolism"
10:20 am - 10:30 am
Discussion
10:30 am - 10:50 am
Sarah Nyquist (Massachusetts Institute of Technology, United States)
"Single Cell RNA-Seq Reveals Cellular and Transcriptional Diversity Over the Course of Human Lactation"
10:50 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Strategies and Planning Tips for Your Next Career Steps in Academia or Industry
Discussion Leader: Sherif Attalla (Goodman Cancer Institute, McGill University, Canada)
1:30 pm - 2:30 pm
Panel Discussion
Strategies and Planning Tips for Your Next Career Steps in Academia or Industry
Beatrice Howard (The Institute of Cancer Research, London, United Kingdom)
Maria Vivanco (CIC bioGUNE, Spain)
Leonie Young (Royal College of Surgeons in Ireland, Ireland)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes