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Mammary Gland Biology (GRS)

Gordon Research Seminar

Impacts of the Environment on the Developing Mammary Gland and Breast Carcinogenesis

May 27 - 28, 2023
Chairs Michelle M. Williams and G. Kenneth Gray
Mount Snow
89 Grand Summit Way
West Dover, Vermont, United States
 Venue and Travel Information

Conference Description

The Mammary Gland Biology GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

The 2023 Mammary Gland Biology GRS will highlight leading-edge research that assesses the impact of the environment, including environmental factors and the microenvironment, on mammary gland development and disease. Discussion will center on emerging technologies used to interrogate these normal and neoplastic processes. The goal of this meeting is to encourage open conversation and the sharing of ideas among young investigators in the fields of mammary gland biology and breast cancer research. This GRS will also include a keynote presentation from a leader in the field, and a special session for early career researchers focused on training opportunities at the National Cancer Institute (NCI) and grantsmanship.

Related Meeting

This GRS will be held in conjunction with the "Mammary Gland Biology" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Lessons for the Future of Academic Breast Cancer Research from a Productive Past
Discussion Leader: Mike Oliphant (Harvard Medical School, United States)
3:45 pm - 4:25 pm
Heide Ford (University of Colorado Anschutz Medical Campus, United States)
"34 Years in Academic Breast Cancer Research: Can We Do Everything, Everywhere, All at Once?"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Technologies and Alternative Models to Interrogate Mammary Gland Biology and Disease
Discussion Leader: Krystopher Maingrette (Rutgers - The State School of New Jersey, United States)
7:30 pm - 7:50 pm
James Miller (Cornell University, United States)
"A Novel Xenotransplantation Mouse Model to Study Mammary Gland Pathogenesis of Large Mammals"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Sounak Sahu (National Cancer Institute (NCI), NIH, United States)
"Directed Self-Assembly of Mouse ES Cells into Mammary Organoids Reveals the Dichotomy Between Skin and Mammary Gland Development"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Amelia Hasenauer (ETH Zürich, Switzerland)
"Engineering Mammary Tissue Using Volumetric Bioprinting and Decellularized Extracellular Matrix-Based Materials"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Ramsey Jenschke (Texas A&M University, United States)
"Changes in Mitochondrial Respiratory Chain Super Complexes Across Functional Mammary Gland Development"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Shengsen Ding (BC Cancer, Canada)
"Characterization of Normal Human Male Mammary Cells and Induction of Male Breast Tumour Formation"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Carson Broeker (Michigan State University, United States)
"The MMTV-Myc Mouse Model Recapitulates Human Breast Cancer Heterogeneity"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Environmental Impacts on the Developing and Neoplastic Mammary Gland
Discussion Leader: Ramiah Vickers (Texas A&M University, United States)
9:00 am - 9:20 am
Maryknoll Linscott (Pennsylvania State University College of Medicine, United States)
"Carcinogen-Initiated Mammary Cancer: Progression of Genetically Distinct Premalignant Clones Upon MYC and PIK3CA Expression"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Jakub Sumbal (Institut Curie, France - Masaryk University Czechia, France)
"Peri-TEB Myofibroblasts Instruct Mammary Branching Morphogenesis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Brenna Walton (University of Wisconsin-Madison, United States)
"Acrylamide Exposure Enhances Oxidative Stress Leading to DNA Damage in the Obese Mouse Mammary Gland"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Nicole Traugh (Tufts University, United States)
"Studying Breast Epithelial-Immune Interactions in A Biomimetic Tissue Model"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Connor Hughes (University of Colorado AMC, United States)
"Eya3 Expression in Triple Negative Breast Cancer Alters Tumor Cell Aggressiveness and The Tumor Immune Microenvironment by Promoting Activation of NF-kB Signaling"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Laura Kammel (NIEHS, United States)
"Circadian Disruption Induces Breast Cancer-Permissive Estrogen Receptor Transcriptional Program in Hormone Sensitive Mammary Epithelium"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: How the NCI Can Help Advance Your Training and Career
Discussion Leader: Abbey Williams (University of Wisconsin - Madison, United States)
1:30 pm - 2:15 pm
Erika Ginsburg (NCI Center for Cancer Training, United States)
"National Cancer Institute (NCI) Training Opportunities"
2:15 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes

Contributors

National Institutes of Health (NIH)

University of Colorado Cancer Center

Breast Cancer Research Foundation

Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number R13CA281280. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History Mammary Gland Biology
Additional Fee Info

Mammary Gland Biology
June 8 - 13, 2025


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