SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Innovations in the Discovery, Investigation and Development of Biologically Active Natural Products - Part I |
| Discussion Leader: Yali Fu (National Cancer Institute) |
7:40 pm - 8:10 pm | Guy T. Carter (Carter-Bernan Consulting)
"Genes, Germs & Deals: The Future of Marine NP Drug Discovery" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Ryan Van Wagoner (University of Utah)
"Filling a Niche - Virtual Screening as a Tool for Selective Screening of Marine Natural Product Libraries" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | William Gerwick (Scripps Institution of Oceanography, University of California San Diego)
"Discovery and Development of Novel Anticancer-type Natural Products from Marine Cyanobacteria" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Innovations in the Discovery, Investigation and Development of Biologically Active Natural Products - Part II |
| Discussion Leader: Chris Ireland (University of Utah) |
9:00 am - 9:10 am | Opening Remarks |
9:10 am - 9:45 am | William Fenical (Scripps Institution of Oceanography, University of California, San Diego)
"Unculturable (Uncultured) Microbes and the Drug Discovery Paradigm" |
9:45 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Group Photo / Coffee Break |
10:30 am - 11:00 am | A Brief Glimpse into Some of Today's Posters |
| Discussion Leader: David Newman |
| Michael Freeman (University of Bonn)
"Polytheonamides: Surprising Biosynthesis of Giant Sponge Toxins" |
| Rana Montaser (University of Florida)
"Chemistry and Biology of Novel Cyanobacterial Secondary Metabolites from Guam and Design of Synthetic Probes to Investigate their Mechanisms of Action" |
| Tanya Grkovic (Griffith University)
"Dereplicating the Drug-like Natural Product Metabolome: Isolation of Iotrochotadines A - D from an Australian Marine Sponge Iotrochota sp." |
| Zhenyu Lu (University of Utah)
"Thiazoline Peptides and a Tris-Phenethyl Urea from Didemnum molle with Anti-HIV Activity" |
| Kensuke Kaneko (Hokkaido University)
"Study on Bromination Enzyme from the Red Alga Laurencia nipponica" |
| Matthew Jamison (University of Texas, Southwestern Medical Center)
"Isolation and Characterization of Mangrolide A" |
11:00 am - 11:30 am | Edward Suh (Eisai Inc.)
"Eisai's Natural Product Drug Discovery: Accomplishments, Research and Personal Perspective" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Frank Koehn (Pfizer)
"Antibody-Drug Conjugates - New Opportunities for Natural Products in Oncology" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Innovations in the Discovery, Investigation and Development of Biologically Active Natural Products - Part III
|
| Discussion Leader: Shmuel Carmeli (Tel Aviv University) |
7:30 pm - 8:00 pm | Philip Williams (University of Hawai'i, Manoa)
"Adventures in Natural Products"
|
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Kirk Gustafson (National Cancer Institute)
"Natural Products Discovery at the NCI: New Chemotypes, Activity Profiles, and Challenges"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Ryuichi Sakai (Hokkaido University)
"Biologically Active Ribosomal Peptides from Sponges" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Advances in Biosynthesis of Marine Natural Products |
| Discussion Leader: Joern Piel (University of Bonn, Kekulé-Institute of Organic Chemistry and Biochemistry) |
9:00 am - 9:10 am | Opening Remarks |
9:10 am - 9:45 am | Marcel Jaspars (University of Aberdeen)
"Biosynthetic Studies on the Patellamides"
|
9:45 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Jason Kwan (The University of Utah)
"A New Family of Ascidian Symbionts Make Patellazoles and Other Complex Polyketides"
|
10:50 am - 11:00 am | Discussion |
11:00 am - 11:30 am | Amy Lane (The University of North Florida)
"Biosynthesis of Anticancer Natural Products from Marine Actinomycetes"
|
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Peter Bernhardt (Institution of Oceanography, Skaggs School of Pharmacy, UCSD)
"A New Bacterial Strategy for the Chlorination of Natural Products"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I (continued) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Advances in Technologies that Enable Natural Products Discovery |
| Discussion Leader: Phillip Crews (University of California, Santa Cruz) |
7:30 pm - 8:00 pm | Kerry McPhail (Oregon State University)
"Configurational Assignment of New Glycosylated Macrolides using NMR Methods" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Timothy Bugni (University of Wisconsin, Madison)
"Mass Spectrometry-based Informatics to Support Natural Products Discovery"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Mark O'Neill-Johnson (Sequoia Sciences, Inc.)
"Who Will Get You There Quicker, Fred Flintstone or George Jetson?"
|
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Synthesis, Medicinal Chemistry and Chemical Biology or Marine Natural Products |
| Discussion Leader: Tadeusz "Ted" Molinksi (University of California, San Diego) |
9:00 am - 9:10 am | Opening Remarks |
9:10 am - 9:45 am | Daniel Romo (Texas A&M University)
"Mining the Information-Rich Content of Natural Products via Synthesis and Derivatization" |
9:45 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 11:00 am | A Brief Glimpse into Some of Today's Posters |
| Discussion Leader: David Newman |
| Rebecca Pike (University of Prince Edward Island)
"Exploring the Diversity and Marine Natural Product Potential of Microbes Associated with Eunicea fusca" |
| Margaret Teasdale (Georgia Institute of Technology)
"Bromophycoic acids: Bioactive Natural Products from an Understudied Fijian Red Alga of the Order Gigartinales" |
| Amaro Trindade-Silva (Universidade de Sao Paulo)
"Metagenomics of the Sponge Holobiont Arenosclera brasiliensis" |
| Hajime Shibata (Osaka University)
"Synthetic Study for the Structure Elucidation of an Endogenous Sperm Activating and Attracting Factor Isolated from Eggs of the Ascidian Ascidia sydneiensis" |
| Priscilla Winder (Florida Atlantic University)
"Progress Towards the Structure Elucidation of Caysalamide, a Cyclic Depsipeptide from a Deep-water Lithistid Sponge" |
| E. Paige Stout (University of California, San Diego)
"Metabiosynthesis of Benzosceptrins and Nagelamides: Implications for Pyrrole-Aminoimidazole Alkaloid Biosynthesis" |
11:00 am - 11:30 am | Robert A. Britton (Simon Fraser University)
"Chlorohydrins: Versatile Building Blocks for the Synthesis of Marine Natural Products"
|
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Greg Roth (Sanford Burnham Medical Research Institute, Lake Nona)
"Design and Synthesis of Medicinally Relevant Marine Natural Products"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Chemical Biology and Mode of Action of Natural Products |
| Discussion Leader: Lena Gerwick (Scripps Institution of Oceanography, University of California, San Diego) |
7:30 pm - 8:00 pm | Andrea Bourdelais (University of North Carolina, Wilmington)
"Use of Ladder Frame Polyethers as Drug Transporters"
|
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Esther Guzmán (Harbor Branch Oceanographic Institute, Florida Atlantic University)
"Inflammation, Cancer and Marine Natural Products"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Daniel La Barbera (University of Colorado, Denver)
"Marine Natural Products: Modulators of the Mesenchymal Phenotype and Potential Therapies for the Treatment of Metastatic Cancer"
|
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Biodiversity and Chemical Ecology of Marine Natural Products |
| Discussion Leader: Julia Kubanek (Georgia Institute of Technology) |
9:00 am - 9:10 am | Opening Remarks |
9:10 am - 9:45 am | Joseph Pawlik (University of North Carolina, Wilmington)
"The Chemical Ecology of Sponges on Caribbean Reefs: Natural Products Shape Natural Systems"
|
9:45 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Sharon Xu (The Hong Kong University of Science)
"Bacterial Biosynthesis and Activation of the Didemnin Anticancer Agents" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:30 am | Valerie Paul (Smithsonian Marine Station)
"Marine Chemical Ecology in a Changing Ocean" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Mark T Hamann (University of Mississippi, Oxford)
"Success and Challenges in Understanding Host-Microbe Interactions in the Production of Natural Products"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II (continued) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Inspirational Natural Products Research |
| Discussion Leader: Bradley Moore (Scripps Institution of Oceanography, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego) |
7:30 pm - 8:00 pm | Roger Linington (University of California, Santa Cruz)
"Image-based Screening Approaches to Natural Products Discovery" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 9:15 pm | Raymond Andersen (University of British Colombia)
"Sponging Off Nature For New Drug Leads" |
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |