| SUNDAY |
| 4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Introductory Comments by GRC Site Staff / Welcome by the GRC Conference Chair |
| 7:40 pm - 9:30 pm | Marine Sponges as Sources of New Drug Leads |
| 7:40 pm - 7:50 pm | Discussion Leader: Phil Crews (UC Santa Cruz)
"Opening Remarks" |
| 7:50 pm - 8:15 pm | Amy Wright (Harbor Branch Oceanographic Institute)
"Investigation of Natural Products Effective Against Cancer and Infectious Disease"
|
| 8:15 pm - 8:25 pm | Discussion |
| 8:25 pm - 9:05 pm | Joern Piel (ETH-Zurich)
"Microbial Dark Matter: A Metabolic Treasure Trove"
|
| 9:05 pm - 9:20 pm | Discussion |
| 9:20 pm - 9:30 pm | Recap of MNP GRS by Laura Sanchez and Peter Jordan (UC San Diego) |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | New Insights into Marine Peptide Chemical Biology |
| Discussion Leader: Eric Schmidt (University of Utah) |
| 9:00 am - 9:35 am | Wilfred van der Donk (University of Illinois)
"Lanthipeptide Biosynthesis in Marine Cyanobacteria"
|
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:00 am | Poster Talk: Marcy Balunas (University of Connecticut)
"Lead Development of Santacruzamate A Analogs as Selective Histone Deacetylase Inhibitors"
|
| 10:00 am - 10:05 am | Discussion |
| 10:05 am | Coffee Break |
| 10:35 am - 11:10 am | Janet Smith (University of Michigan)
"Structural Biology of PKS Modules"
|
| 11:10 am - 11:25 am | Discussion |
| 11:25 am - 11:35 am | Poster Talk: Matthew Bertin (UC San Diego)
"Novel Nucleosides from the Marine Sponge Tectitethya crypta and Its Microorganism Symbionts"
|
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 12:15 pm | Baldomero Olivera (University of Utah)
"Conus Venom Peptides, Cabals and Constellation Pharmacology"
|
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Marine Natural Products in Cancer |
| 7:30 pm - 7:40 pm | Discussion Leader: Frank Koehn (Pfizer)
"Opening Remarks" |
| 7:40 pm - 8:20 pm | Peter Senter (Seattle Genetics)
"Antibodies Linked to Marine Derived Natural Products: From Early Stage Discovery to an Approved Drug"
|
| 8:20 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:15 pm | Carmen Cuevas (PharmaMar)
"Marine Natural Products at PharmaMar: New Clinical Compounds and New Development Strategies"
|
| 9:15 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Chemical and Biosynthetic Versatility of Marine Microbes |
| Discussion Leader: David Rowley (University of Rhode Island) |
| 9:00 am - 9:35 am | Paul Jensen (UC San Diego)
"Genomic Insights into the Evolution of Secondary Metabolism in a Model Group of Marine Bacteria"
|
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:00 am | Poster Talk: Rajesh Viswanathan (Case Western Reserve University)
"Characterization of the Hapalindole Gene Cluster from Four Distinct Strains of Group V Cyanobacteria"
|
| 10:00 am - 10:05 am | Discussion |
| 10:05 am | Coffee Break |
| 10:35 am - 11:10 am | Carlos Jimenez (University of A Coruna)
"Siderophores and Iron Uptake in Fish Aquaculture Pathogen Bacteria: Isolation, Structures, Synthesis and Applications"
|
| 11:10 am - 11:25 am | Discussion |
| 11:25 am - 11:35 am | Poster Talk: Vinayak Agarwal (UC San Diego)
"Biosynthesis of Polybrominated Organic Compounds by Marine Bacteria" |
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 12:15 pm | Margo Haygood (Oregon Health & Science University)
"Bioactive Compounds from Bacterial Symbionts of Mollusks"
|
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Illuminating the Biological Role of Natural Products in the Marine
Environment
|
| 7:30 pm - 7:40 pm | Discussion Leader: Valerie Paul (Smithsonian Marine Station)
"Opening Remarks" |
| 7:40 pm - 8:20 pm | Georg Pohnert (University of Jena)
"Metabolomics Enabled Identification of Infochemicals from Marine Diatoms"
|
| 8:20 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:15 pm | Mark Hay (Georgia Institute of Technology)
"Chemical Ecology Affects the Structure, Function, and Future of Coral Reefs: Recovery or a Continuing Biotic Death Spiral?"
|
| 9:15 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Modern Advances in Mass Spectrometry to Characterize Natural Products |
| Discussion Leader: Tim Bugni (University of Wisconsin-Madison) |
| 9:00 am - 9:35 am | Pieter Dorrestein (UC San Diego)
"A 'GoogleMAP'-Type Molecular View of Microbial Communities"
|
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:00 am | Poster Talk: Catherine Roullier (University of Nantes)
"Targeting the Halogenated Metabolome of Marine-Derived Fungi Using LC-HRMS/MS Tools"
|
| 10:00 am - 10:05 am | Discussion |
| 10:05 am | Coffee Break |
| 10:35 am - 11:10 am | Ales Svatos (University of Jena)
"Mass Spectrometric Imaging of Signal Molecules, New Tool for Chemical Ecology"
|
| 11:10 am - 11:25 am | Discussion |
| 11:25 am - 11:35 am | Poster Talk: Tanja Grkovic (Eskitis Institute, Griffith University)
"Seeing the Invisible: Comprehensive NMR Fingerprint of the Drug-Like Natural Product Metabolome"
|
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 12:15 pm | Graham Cooks (Purdue University)
"Ambient Mass Spectrometry Based Isolation and Characterization of Natural Products"
|
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Inspirational Advances in Making and Characterizing Complex Marine
Natural Products
|
| 7:30 pm - 7:40 pm | Discussion Leader: Frank Schroeder (Cornell University)
"Opening Remarks" |
| 7:40 pm - 8:20 pm | Phil Baran (Scripps Research Institute)
"Studies in Natural Product Synthesis"
|
| 8:20 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:15 pm | Makoto Fujita (University of Tokyo)
"Crystal-Free Crystallography for the Nano-to-Micro Gram Scale Structure Analysis: Principle, Applications, and Scope & Limitations"
|
| 9:15 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Natural Product Library Screening and Target Identification |
| Discussion Leader: Chambers Hughes (UC San Diego) |
| 9:00 am - 9:30 am | Hendrik Luesch (University of Florida)
"Specific Targeting of Cancer Relevant Pathways for MNP Discovery"
|
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 9:55 am | Poster Talk: Daniela Trivella (Brazilian Biosciences National Laboratory)
"Marine Natural Products as Human Protein Tyrosine Phosphatase Inhibitors" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Dong Chan Oh (Seoul National University)
"Discovery of New Bioactive Peptides from Korean Marine Actinomycetes"
|
| 11:00 am - 11:15 am | Discussion |
| 11:15 am - 11:25 am | Poster Talk: Shinichi Nishimura (Kyoto University)
"Mode of Action of Heronamides, Polyene Macrolactams from a Marine-Derived Streptomyces sp."
|
| 11:25 am - 11:30 am | Discussion |
| 11:30 am - 12:10 pm | James Inglese (National Center for Advancing Translational Sciences, NIH)
"Design of Assays and Screening Strategies for the Interrogation of Natural Product Extracts"
|
| 12:10 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Innovations in Marine Natural Products Research |
| Discussion Leader: Julia Kubanek (Georgia Institute of Technology) |
| 7:30 pm - 8:00 pm | Brent Copp (University of Auckland)
"The Fun Never Stops: (Biomimetic) Synthesis and SAR Studies of Ascidian Natural Products"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 9:10 pm | Chris Ireland (University of Utah)
"From Sea Hunt to Dean of Pharmacy - What a Strange and Wonderful Trip it's Been"
|
| 9:10 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
