Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Cryptic Microbial Metabolites
Discussion Leader: Roger Linington (Simon Fraser University, Canada)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:20 pm
Paul Jensen (Scripps Institution of Oceanography / University of California, San Diego, USA)
"The Ecology and Evolution of Natural Products in Marine Actinobacteria"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
Katherine Ryan (University of British Columbia, Canada)
"Microbial Biosynthesis of Heterocyclic Natural Products"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Jaclyn Winter (University of Utah, USA)
"Unlocking the Chemical Potential of the Fungal Terpenome"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Marine Natural Products as Therapeutics and Molecular Probes
Discussion Leader: Carole Bewley (National Institutes of Health, USA)
9:00 am - 9:30 am
John MacMillan (University of California, Santa Cruz, USA)
"Chemistry-First Approach to Identify Novel Targets for Personalized Treatment in Lung Cancer"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Mande Holford (Hunter College, City University of New York / American Museum of Natural History, USA)
"The Evolution and Therapeutic Application of Venom from Predatory Marine Snails"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Peter Senter (Seattle Genetics, USA)
"Considerations for Development and Launch of a Successful Antibody-Drug Conjugate"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Fan Zhang (University of Wisconsin-Madison, USA)
"Turbinmicin, a New Antifungal with Potent In Vivo Efficacy Against Pan Resistant Candida auris and Aspergillus fumigatus "
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Franziska Hemmerling (ETH Zurich, Switzerland)
"A Chemically Rich Sponge Symbiont Identified by Single-Cell Genomics and Raman Microscopy"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Raphael Reher (University of California, San Diego, USA)
"A SMART Approach for Natural Product Discovery"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Julia Kubanek (Georgia Institute of Technology, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Tools in the Structure Elucidation Tool Box
Discussion Leader: Tadeusz Molinski (University of California, San Diego, USA)
7:30 pm - 8:00 pm
Alison Butler (University of California, Santa Barbara, USA)
"Siderophores in Stereo: Targeting Structural Diversity in the Discovery of New Siderophores"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Richmond Sarpong (University of California, Berkeley, USA)
"Preparation and Structural Elucidation of Sesquiterpenoid Marine Natural Products"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Josep Saurí (Merck & Co. Inc., USA)
"Advanced NMR Methods for Structure Elucidation of Complex Organic Molecules"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Robert Williamson (University of North Carolina Wilmington, USA)
"Redefining the Role of NMR in the Structure Elucidation of Marine Natural Products"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Secondary Metabolite Biosynthesis, Enzymology and Genomics
Discussion Leader: Nadine Ziemert (University of Tübingen, Germany)
9:00 am - 9:30 am
Elke Dittmann (University of Potsdam, Germany)
"Understanding the Bottlenecks in Cyanobacterial Natural Product Research"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Marnix Medema (Bioinformatics Group, Wageningen University & Research, The Netherlands)
"Computational Omics of Microbial Biosynthetic Diversity: From Natural Product Discovery to Microbiome Ecology"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Alison Narayan (University of Michigan, USA)
"Biocatalysis and Complex Molecule Synthesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Alison Murray (Desert Research Institute, USA)
"Ascidian Microbiome Metagenomics: In Search of the Palmerolide Biosynthetic Gene Cluster"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Michael Freeman (University of Minnesota, USA)
"Progress in α-N -Methylated RiPP Biosynthesis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
James La Clair (Xenobe Research Institute, USA)
"Synthase-Guided Single Cell Genomics"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Enhanced Screening and Discovery Platforms for Natural Products
Discussion Leader: Shmuel Carmeli (Tel Aviv University, Israel)
7:30 pm - 8:00 pm
Tanja Grkovic (Leidos Biomedical Research Inc, USA)
"National Program for Natural Product Discovery, Generation of a Prefractionated Library for High Throughput Screening"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Dong-Chan Oh (Seoul National University, South Korea)
"Genomic and Spectroscopic Signature-Based Discovery of Bioactive Natural Products"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Chase Clark (University of Illinois at Chicago, USA)
"IDBac: Bioinformatics Software for Microbial Drug Discovery Prioritization and Culturomics Characterization"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Serina Robinson (BioTechnology Institute, University of Minnesota, USA)
"Genome Mining-Guided Insights into Beta-Lactone Natural Product Biosynthesis"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Development and Application of New Enabling Technologies
Discussion Leader: Ronald Quinn (Griffith University, Australia)
9:00 am - 9:30 am
Makoto Fujita (University of Tokyo, Japan)
"Crystalline-Sponge Method for Natural Products Chemistry and Drug Discovery"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Laura Sanchez (University of Illinois at Chicago, USA)
"Visualizing Chemical Communication in Host-Microbe Interactions with Imaging Mass Spectrometry"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Hosea Nelson (University of California, Los Angeles, USA)
"New Methods Enabling the Synthesis and Characterization of Natural Products"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Andrei Kutateladze (University of Denver, USA)
"DU8+: Structure Validation/Revision Made Easy with Fast and Accurate Computations of Nuclear Spin Coupling Constants and Chemical Shifts"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Robert Britton (Simon Fraser University, Canada)
"Total Synthesis of THF-Containing Marine Macrolides"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Anthony Carroll (Griffith University, Australia)
"Development of NMR Tools to Discover Unique Natural Products in Complex Mixtures"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Mechanisms of Action and Molecular Targets
Discussion Leader: Barry O'Keefe (National Cancer Institute, NIH, USA)
7:30 pm - 8:00 pm
Miaomiao Liu (Griffith University, Australia)
"Pheno-Target Drug Discovery from Natural Products Using Native Mass Spectrometry"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Hendrik Luesch (University of Florida, USA)
"A Multidimensional Profiling Platform to Unlock the Mechanisms and Therapeutic Potential of MNPs"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Daniela Trivella (National Center for Research in Energy and Materials (CNPEM), Brazil)
"The NP3 Approach for Capture and Validation of Protein-Targeted Bioactive Natural Products: Recent Advances Using Marine Natural Products"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Wendy Strangman (University of North Carolina Wilmington, USA)
"Metabolomics and Mass Spectrometry-Based Bioassay Development for Compound Discovery from Harmful Algal Blooms"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Functional and Ecological Roles of Natural Products
Discussion Leader: Julia Kubanek (Georgia Institute of Technology, USA)
9:00 am - 9:30 am
Yehuda Benayahu (Tel Aviv University, Israel)
"Mesophotic Marine Ecosystems: Inspiring Understudied Resource"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
J. P. Gerdt (Indiana University, USA)
"Interspecies Chemical Sensing in an Evolutionary Model and Potential Biocontrol Agent"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Euna Yoo (National Cancer Institute, NIH, USA)
"Chemoproteomic Approach for Target Discovery of Natural Products"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Matthew Bertin (University of Rhode Island, USA)
"A Multi-Year Investigation into the Secondary Metabolite Composition of Trichodesmium Blooms"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Christina Kellogg (U.S. Geological Survey, USA)
"Deep-Sea Coral Microbiomes as a Source for Novel Natural Products"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Vinayak Agarwal (Georgia Institute of Technology, USA)
"Genetic and Biochemical Reconstruction of Ozone-Depleting Bromoform Production by Marine Macroalgae"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Future Directions in Marine Natural Products Discovery
Discussion Leader: Kerry McPhail (Oregon State University, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
Alexander M. Cruickshank Lecture: Bradley Moore (University of California, San Diego, USA)
"Expanding Marine Natural Product Genome Mining and Synthetic Biology Horizons"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Introduction by Discussion Leader
8:30 pm - 9:15 pm
Valerie Paul (Smithsonian Institution, USA)
"Sea Slugs, Slime and Coral Diseases: Chemical Ecology and Our Changing Ocean"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure