Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Developing Marine Natural Product Therapies
Discussion Leader: Edmund Graziani (Apertor Pharmaceuticals Inc., United States)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:20 pm
Kris White (Icahn School of Medicine at Mount Sinai, United States)
"Host-targeted Antiviral Development, Treating the Current Pandemic and Preparing for the Next"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Amy Fraley (ETH Zurich, Switzerland)
"Thioesterase-Mediated O-Acetylation and Double Bond Formation in Peloruside Biosynthesis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Andreas Maderna (Sutro Biopharma, Inc., United States)
"Marine Natural Products and Antibody Drug Conjugates: A Journey from the Ocean’s Deep to the Clinic"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Climate Change, Marine Toxins and Environmental Solutions
Discussion Leader: Marcel Jaspars (University of Aberdeen, United Kingdom)
9:00 am - 9:30 am
Taifo Mahmud (Oregon State University, United States)
"Development of Marine-derived Sunscreens and Their Role in Ocean Conservation"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Constanze Kuhlisch (Weizmann Institute of Science, Israel)
"The Ecological Roles of Brominated Indole Alkaloids within Coccolithophore Blooms"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Yuko Cho (Tohoku University, Japan)
"Solving the Mystery of Saxitoxin Biosynthesis in Dinoflagellates: Turn-over, Subcellular Localization and Regulation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Eva Sonnenschein (Technical University of Denmark, Denmark)
"Life on Plastic: Deciphering the Functions of Marine Microbes in the Plastisphere"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Neha Garg (Georgia Institute of Technology, United States)
"Metabolomics Approaches to Probe Probiotic Potential of Cultured Coral-associated Bacteria"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Marine Vallet (Max Planck Institute for Chemical Ecology, Germany)
"Metabolomic Insights into Parasite Diseases of Phytoplankton"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Marcy Balunas (University of Connecticut, United States) and Alanna Condren (University of Michigan, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthetic Biology for Natural Product Production and Engineering
Discussion Leader: Jaclyn Winter (University of Utah, United States)
7:30 pm - 8:00 pm
Alessandra Eustaquio (University of Illinois Chicago, United States)
"Reverse Genetics and Synthetic Biology for Natural Product Discovery and Production"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Brandon Morinaka (National University of Singapore, Singapore)
"Posttranslational Cyclophane Formation in Bacteria"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Katharine Watts (California Polytechnic State University, United States)
"Pinpointing Building Blocks and Amino Acid Ligases in TLN-05220 Biosynthesis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Paul Scesa (University of utah, United States)
"Terpenoid Biosynthesis in Octocorals"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Immo Burkhardt (UCSD - Scripps Institution of Oceanography, United States)
"Biosynthetic Origin of Octocoral Terpenoids"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Super Resolution Imaging for Natural Product Mechanisms
Discussion Leader: Laura Sanchez (University of California at Santa Cruz, United States)
9:00 am - 9:30 am
Edward Boyden (Massachusetts Institute of Technology, Howard Hughes Medical Institute, United States)
"Biomining New Tools For Analyzing and Controlling Complex Biological Systems"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Lu Wei (California Institute of Technology, United States)
"Mapping Biological Processes Through Molecular Vibrations"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Ville Paavilainen (University of Helsinki, Finland)
"Molecular Basis for Substrate-selective Inhibition of Protein Secretion"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Alia Alia Matysik (Leipzig University, Germany and Leiden University, The Netherlands)
"High Resolution MAS NMR Methods for Metabolic Profiling of Intact Zebrafish Embryos Exposed to Harmful Algal Bloom Toxins"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
Manuel Liebeke (Max Planck Institute for Marine Microbiology, Germany)
"Taking a Microscale Look at Symbiotic Interactions: New Metabolites from the Host–Microbe Interface"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthetic Strategies for Natural Product Lead Development
Discussion Leader: Tadeusz Molinski (University of California, San Diego, United States)
7:30 pm - 8:00 pm
Leslie Aldrich (University of Illinois at Chicago, United States)
"Building Biological Performance Diversity and Chasing Challenging Targets for Probe and Drug Discovery"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Eduardo Caro-Diaz (University of Puerto Rico - Medical Sciences Campus, Puerto Rico)
"Walking the Non-biogenic Path: Cyanobacterial Pseudo-natural Products"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Yaoqiu Zhu (The University of Texas at El Paso, United States)
"Bioinspired 3D Printing of Complex Marine Natural Scaffold for Anticancer Lead Discovery"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Sarah Reisman (California Institute of Technology, United States)
"A Chemical Synthesis of Ritterazine B, A Marine Natural Product with Potent Anticancer Activity"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Computational Workflows for Natural Products Discovery
Discussion Leader: Roberto Berlinck (Universidade de São Paulo, Brazil)
9:00 am - 9:30 am
Laura-Isobel McCall (University of Oklahoma, United States)
"Spatial Mass Spectrometry and Data Analysis Approaches for Rational Drug Development"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Roger Linington (Simon Fraser University, Canada)
"NP-Suite: New Tools to Process, Integrate and Annotate Mass Spectrometry and Bioactivity Data for Natural Products"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Hosein Mohimani (Carnegie Mellon University, United States)
"Machine Learning Methods for Discovering Natural Products from Large Mass Spectral Datasets"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Allison Walker (Vanderbilt University, United States)
"Predicting Natural Product Activities with Machine Learning"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Donovon Adpressa (Loxo Oncology at Lilly, United States)
"Conformational Analysis of Flexible Natural Products Based on Sparse Experimental Restraints"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Mehdi Beniddir (Universite Paris-Saclay, France)
"Digging Through the Data: Pursuing the Ideal Natural Product Discovery Scenario"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Lead Discovery, Molecular Targets and Phenotypic Screening
Discussion Leader: Daniela Trivella (National Center for Research in Energy and Materials (CNPEM), Brazil)
7:30 pm - 8:00 pm
Eric Schmidt (University of Utah, United States)
"Ecology-driven Approaches to Biosynthesis and Drug Lead Discovery"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Marsha Pierce (Midwestern University, United States)
"Preclinical Evaluation of Marine Natural Products for Neuroscience Drug Development"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Ashootosh Tripathi (University of Michigan, United States)
"A Mass Spectrometry-based High-throughput Platform for Natural Product Electrophile Discovery and Biological Screening"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Trever Smith II (Tufts University, United States)
"Classifying Drugs Using Morphological Changes in Treated Tubercle Bacilli"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Natural Products in the Context of Microbiomes and Symbioses
Discussion Leader: Shigeki Matsunaga (The University of Tokyo, Japan)
9:00 am - 9:30 am
Margo Haygood (University of Utah, United States)
"The Role of Symbioses in Natural Product Discovery: Discoveries from Bacterial Symbionts of Shipworms"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Emilia Sogin (University of California at Merced, United States)
"Sugars Dominate the Seagrass Rhizosphere"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Robin Teufel (University of Basel, Switzerland)
"The Biosynthesis of Bacterial Tropone Natural Products Important for Marine Symbiotic Interactions Depends on a Novel Flavoprotein Dioxygenase Prototype"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Mohamed Donia (Princeton University, United States)
"Small Molecule-mediated Interactions in Symbiotic Systems"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Emily Mevers (Virginia Polytechnic Institute and State University, United States)
"Chemical Investigations into the Microbiota of Marine Egg Masses"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
Marcy Balunas (University of Connecticut, United States)
"Regulation of Specialized Metabolite Production in Complex Microbiome Systems"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Integrated Strategies for Marine Natural Products Discovery
Discussion Leader: Hendrik Luesch (University of Florida, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Julia Kubanek (Georgia Institute of Technology, United States)
"Integrating Metabolomics into Mechanism of Action Studies of Marine Natural Products"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 9:00 pm
Phillip Crews (UC Santa Cruz, United States)
"Challenges and Adventures During Sponge Natural Products Chemistry Discovery at UCSC: The Good, The Bad, and The Ugly"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
