Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Innovative Approaches to Natural Product Discovery
Discussion Leader: Henrique Machado (Scripps Institution of Oceanography / University of California, San Diego, USA)
3:45 pm - 4:15 pm
John MacMillan (University of California, Santa Cruz, USA)
"Function Driven Natural Products Discovery"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Exploring the Chemistry of the Ocean: Biosynthesis and Classical Discovery Approaches
Discussion Leaders: Nils Hauck (University of Tuebingen, Germany) and Trevor Purdy (University of California, San Diego, USA)
7:30 pm - 7:50 pm
Meredith Skiba (University of Michigan, USA)
"Structural and Biochemical Characterization of t-Butyl Formation in Apratoxin A Biosynthesis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Katherine Bauman (Scripps Institution of Oceanography, USA)
"Connecting Genes to Chemistry - Promoter Refactoring to Awaken Natural Product Biosynthesis in Marine Streptomyces Bacteria"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Emily Mevers (Harvard Medical School, USA)
"Extracellular Electron Transfer Mediated by a Bacterially-Derived Small Molecule"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Christian Schlawis (Technische Universitaet Braunschweig, Germany)
"Highly Sensitive Solid Phase GC/IR Methods in Natural Product Identification"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Talia Pettigrew (University of Cambridge, United Kingdom)
"Designed Aplyronine Warheads for Next-Generation Antibody-Drug Conjugates"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Emerging Techniques and Bold Ideas: Innovative Approaches to Accelerate Discovery
Discussion Leaders: Jonathan Singh (Victoria University of Wellington, New Zealand) and Fred Haeckl (Simon Fraser University, Canada)
9:00 am - 9:20 am
Bethany Okada (Princeton University, USA)
"Natural Product Discovery in Burkholderia thailandensis Through Cryptic Gene Cluster Activation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Ian Miller (University of Wisconsin-Madison, USA)
"Autometa: Automated Extraction of Microbial Genomes from Shotgun Metagenomes"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Carolyn Fisher (Sandia National Laboratories, USA)
"Investigating the Chemical and Biological Landscape of Microalgae Cultures to Mitigate Pond Crashes"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Chen Zhang (University of California, San Diego, USA)
"Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Discovery - An NMR Spectral Noise Study"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Anam Shaikh (University of Texas Southwestern Medical Center, USA)
"Functional Signature Ontology (FUSION) Mapping for Rapid Mechanism of Action Discovery"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Beyond Bioactivity: Understanding the Ecological Roles of Marine Natural Products
Discussion Leaders: Skylar Carlson (Smithsonian Marine Station at Fort Pierce, USA) and Samantha Gromek (University of Connecticut, USA)
1:30 pm - 1:45 pm
Christopher Leber (Scripps Institution of Oceanography, USA)
"Toxins of Choice: How a Weaving Shrimp Drives Patterns in the Chemical Composition of a Cyanobacterium"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Katherine Zink (University of Illinois at Chicago, USA)
"Translating Communication Chemicals that Regulate a Well-Studied Inter-Kingdom Symbiosis"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Joseph Gerdt (Harvard Medical School, USA)
"Bacterial Signals Regulate Multicellularity and Mating in Animals' Closest Relative"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes