SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Introductory Comments by GRC Site Staff |
7:35 pm - 7:45 pm | Welcome by John Huguenard and Carolyn Houser, Chair and Vice-Chair |
7:45 pm - 9:30 pm | Epileptic ion channels and synaptic proteins |
7:45 pm - 7:50 pm | Discussion Leader: Istvan Mody (UCLA)
"Introduction" |
7:50 pm - 8:15 pm | Heinz Beck (University of Bonn)
"Excitable properties of small caliber hippocampal dendrites" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:50 pm | David Bredt (Eli Lily)
"Regulation of neuronal excitability by AMPA auxiliary subunits" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Hee-Sup Shin (Korea Inst. of Science and Tech.)
"R-type calcium channels in oscillatory burst discharges of nRT neurons and absence seizures" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Stem Cells and Epilepsy |
9:00 am - 9:05 am | Discussion Leader: Helen Scharfman (NYU)
"Introduction" |
9:05 am - 9:30 am | Jack Parent (Univ. Michigan)
"Reelin and seizure-induced neurogenesis and neuroblast migration" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Linda Overstreet-Wadiche (Universty of Alabama, Birmingham)
"Seizures and integration of adult-born neurons" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:40 am | Coffee Break |
10:40 am - 10:50 am | Lori Isom (University of Michigan)
"Na+ channel Beta 1B: a secreted cell adhesion molecule involved in human epilepsy" |
10:50 am - 10:55 am | Discussion |
10:55 am - 11:20 am | Jenny Hsieh (UTSW)
"Seizure-induced epigenetic modifications alter adult neurogenesis" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Steve Danzer (Cincinnati Children's Hospital Med Ctr)
"Contributions of adult-generated granule cells to aberrant hippocampal circuitry and epileptogenesis" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Elsa Rossignol (NYU)
"Defective cortical interneuronal signaling results in generalized seizures" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Group Photo / Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Inhibitory neurons: failure to deliver |
7:30 pm - 7:35 pm | Discussion Leader: Joseph LoTurco (University of Connecticut)
"Introduction" |
7:35 pm - 7:55 pm | Elizabeth Powell (University of Maryland)
"Functional consequences of altered forebrain interneuron ontogeny" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | John Rubenstein (UCSF)
"Molecular mechanisms regulating interneuron specification and migration" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Antoine Triller (INSERM, Paris)
"Activity-dependent GABA receptor trafficking" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Scott Baraban (UCSF)
"Seizures and altered inhibition in Dlx mutant mice" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Circuit Homeostasis, Analytical and Experimental approaches in Epilepsy |
9:00 am - 9:05 am | Discussion Leader: Ivan Soltesz (UC Irvine)
"Introduction" |
9:05 am - 9:30 am | Liset Menendez de la Prida (Instituto Cajal, Madrid)
"Hippocampal rhythms and epilepsy" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Carlos Aizenman (Brown University)
"Polyamine-mediated regulation of seizure threshold in a developmental model of epilepsy" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:40 am | Coffee Break |
10:40 am - 10:50 am | Helen Sabolek (Massachusetts General Hospital)
"GABAergic inhibition sculpts the spread of interictal activity" |
10:50 am - 10:55 am | Discussion |
10:55 am - 11:20 am | Michael Sutton (University of Michigan)
"Local homeostatic control of synapse function" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Gina Turrigiano (Brandeis University)
"Network synaptic scaling in neocortex" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Catherine Christian (Stanford University)
"Disruption of the GABAAR alpha3 subunit benzodiazepine binding site alters intra-thalamic inhibition and absence seizures" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Epigenetics, gene regulation and microRNAs in Epilepsy |
7:30 pm - 7:35 pm | Discussion Leader: Amy Brooks-Kayal (University of Colorado)
"Multiple levels and mechanisms of gene regulation in epilepsy: how do we sort it all out?" |
7:35 pm - 7:55 pm | Douglas Coulter (Children's Hospital of Pennsylvania)
"REST-regulation and epileptogenesis" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Eleanora Aronica (University of Amsterdam)
"Transcriptional and post-transcriptional regulation of gene expression during epileptogenesis" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Hongjun Song (Johns Hopkins University)
"Neuronal activity modifies the epigenetic DNA methylation landscape in the adult brain" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Raymond Dingledine (Emory University)
"Patterns of altered gene expression in experimental epilepsies" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Circuit development and function: basis for epileptic networks |
9:00 am - 9:05 am | Discussion Leader: Uwe Heineman (University of Berlin)
"Introduction" |
9:05 am - 9:30 am | Cagla Eroglu (Duke University)
"Astrocytic thrombospondin and synaptogenesis" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Hisashi Umemori (University of Michigan)
"Wiring the functional brain" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:40 am | Coffee Break |
10:40 am - 10:50 am | Rebecca Boumil (The Jackson Laboratory)
"A missense mutation in a highly conserved alternate exon of dynamin-1 causes epilepsy in fitful mice" |
10:50 am - 10:55 am | Discussion |
10:55 am - 11:20 am | Robert Wong (SUNY Downstate Medical Center)
"mGluR network plasticity and epilepsy" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:55 am | John Jefferys (University of Birmingham)
"High frequency activity in temporal lobe epilepsy" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | William Stacey (University of Michigan)
"Modulation of epileptiform activity with coupling and synaptic noise" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Microcircuit Dynamics: Emergence of synchrony |
7:30 pm - 7:35 pm | Discussion Leader: Kevin Staley (Mass. General Hospital)
"Introduction" |
7:35 pm - 7:55 pm | Michael Hausser (University College, London)
"Microcircuits and synchronization of cerebellar activity" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Rafa Yuste (Columbia University)
"Imaging and optically controlling epileptiform events" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Marlene Bartos (University of Aberdeen)
"Distance dependent inhibitory signalling - a new mechansims of cortical network synchronization" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Edward Boyden (MIT)
"New Optical Reagents and Strategies for Controlling Neural Circuit Dynamics" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Neuroinflammation and Epilepsy |
9:00 am - 9:05 am | Discussion Leader: Karen Wilcox (University of Utah)
"Inflammatory remarks" |
9:05 am - 9:30 am | Annamaria Vezzani (Mario Negri Institute for Pharmacological Research)
"Brain inflammation, seizures and epileptogenesi" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Daniela Kaufer (UC Berkeley)
"TGF-beta signaling in epileptogenesis following BBB compromise" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:40 am | Coffee Break |
10:40 am - 10:50 am | Jerome Clasadonte (Tufts University)
"Astrocyte-dependent regulation of synaptic NMDA receptors modulates seizure activity" |
10:50 am - 10:55 am | Discussion |
10:55 am - 11:20 am | Jean-Marc Fritschy (University of Zurich)
"Regulation of epileptogenesis and seizures by innate and adaptive immunity" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Rita Balice Gordon (University of Pennsylvania)
"Astrocytes secrete proteins that selectively modulate inhibitory axon length, branching and synapse formation" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Sally Duarte (University of Rochester)
"Elucidating the neuronal and network mechanisms of ictogenesis" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Epileptogenesis: occult and overt mechanisms |
7:30 pm - 7:35 pm | Discussion Leader Frances Jensen (Children's Hospital, HMS)
"Going 'outside the box' to search for novel antiepileptogenic targets" |
7:35 pm - 7:55 pm | Michael Wong (Washington University, St. Louis)
"The mammalian target of rapamycin (mTOR) pathway: a central mechanism of epileptogenesis in multiple types of epilepsy?" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Christophe Bernard (INSERM, Marseille)
"HCN alterations in the 'latent' period" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Ed Dudek (University of Utah)
"Challenges and strategies for studying acquired epileptogenesis" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Final Discussion & Summary |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |