SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
5:00 pm - 6:00 pm | Welcome Reception (Meet and relax before dinner!) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 7:50 pm | Welcome by Carolyn Houser (Chair), Jack Parent (Vice Chair) and Scott Baraban (Vice Chair) |
7:50 pm - 9:30 pm | Challenges for Epilepsy Research |
7:50 pm - 8:00 pm | Discussion Leader: David Prince (Stanford University) "Introduction" |
8:00 pm - 8:30 pm | Dan Lowenstein (U. of California, San Francisco)
"Translational research in epilepsy: The prognosis"
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8:30 pm - 8:45 pm | Discussion |
8:45 pm - 9:15 pm | Istvan Mody (U. of California, Los Angeles)
"The new landscape of research in the epilepsies"
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9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Epileptogenesis: Can we prevent it? |
9:00 am - 9:30 am | Discussion Leader: Douglas Coulter (Children's Hospital of Pennsylvania)
"Introduction" |
9:30 am - 9:55 am | Tallie Z. Baram (U. of California, Irvine)
"Constructing 'epileptic neurons': A role for epigenetic mechanisms"
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9:55 am - 10:05 am | Discussion |
10:05 am - 10:15 am | Nigel Jones (University of Melbourne)
"The enduring effects of early-life stress on limbic epileptogenesis are mediated by HPA axis hyper-reactivity"
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10:15 am - 10:20 am | Discussion |
10:20 am - 10:55 am | Group Photo / Coffee Break |
10:55 am - 11:20 am | Asla Pitkänen (U. of Eastern Finland)
"Anti-epileptogenesis after traumatic brain injury"
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11:20 am - 11:30 am | Discussion |
11:30 am - 11:55 am | James McNamara (Duke University)
"TrkB signaling and epileptogenesis: In search of a magic bullet"
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11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Jennifer Pearson (U. of Colorado)
"Scavenging of highly reactive gamma-ketoaldehydes attenuates learning and memory deficits in experimental temporal lobe epilepsy"
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12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Seizure Generation: Where do seizures begin and how do they spread? |
7:30 pm - 7:40 pm | Discussion Leader: Christophe Bernard (INSERM, Marseille)
"Introduction"
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7:40 pm - 8:05 pm | Brian Litt (U. of Pennsylvania)
"Network recruitment in seizure generation"
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8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Gilles Huberfeld (ICM, Paris)
"Transition to seizures in human epileptic tissues"
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8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Sydney Cash (Harvard Medical School)
"Neuron dynamics in human focal epilepsy"
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9:15 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Circuit Analysis in Epilepsy with Optogenetics: Lighting up a darkened brain |
9:00 am - 9:10 am | Discussion Leader: Helen Scharfman (New York University)
"Introduction"
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9:10 am - 9:35 am | Karl Deisseroth (Stanford University)
"Recent advances in optogenetics"
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9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Ivan Soltesz (U. of California, Irvine)
"Optogenetic modulation of entorhino-hippocampal circuits in epilepsy"
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10:10 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Coffee Break |
10:45 am - 10:55 am | Fabien Wagner (Brown University)
"Spatiotemporal dynamics of local field potentials and single-unit activity during spontaneous seizures and optically-induced oscillations in a rat model of absence epilepsy"
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10:55 am - 11:00 am | Discussion |
11:00 am - 11:25 am | John Huguenard (Stanford University)
"Mechanisms of seizure initiation deduced by optogenetic approaches"
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11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Jin Hyung Lee (U. of California, Los Angeles)
"Optogenetic functional magnetic resonance imaging and epilepsy"
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12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Sarah Feldt Muldoon (INSERM, Marseille)
"Synchrony and epilepsy: Uncovering functional network structure in the dentate gyrus"
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12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Network Dynamics in Epilepsy: Novel approaches for dissecting functional circuits |
7:30 pm - 7:40 pm | Discussion Leader: John Hablitz (U. of Alabama, Birmingham)
"Introduction"
|
7:40 pm - 8:05 pm | Edward Callaway (The Salk Institute, La Jolla)
"Rabies-based tools for elucidating neural circuit structure and function"
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8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Bal Khakh (U. of California, Los Angeles)
"Imaging calcium signals in entire astrocytes and determining their relationship to neuronal activity"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Andy Trevelyan (Newcastle University)
"The nature of cortical inhibitory restraint in mice and humans"
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9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | GABA System Reorganization in Epilepsy: How many changes can we find? |
9:00 am - 9:10 am | Discussion Leader: Monique Esclapez (INSERM, Marseille)
"Introduction" |
9:10 am - 9:35 am | Gord Fishell (New York University Neuroscience Institute)
"The role of the activity-regulated gene SatB1 in the maturation of cortical interneurons and its relationship to early cortical seizures" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Chris McBain (NIH)
"The role of pentraxins in controlling interneuron glutamate receptor expression, feedforward inhibition and oscillogenesis"
|
10:10 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Coffee Break |
10:45 am - 10:55 am | Robert Hunt (U. of California, San Francisco)
"Progress toward an interneuron-based cell therapy for epilepsy"
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10:55 am - 11:00 am | Discussion |
11:00 am - 11:25 am | Paul Buckmaster (Stanford University)
"Abundant but dysfunctional GABAergic synapses in epilepsy"
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11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Kevin Staley (Massachusetts General Hospital)
"Subcellular chloride distribution, GABA signaling and seizures"
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12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Leonie Pothmann (U. of Bonn Medical Center)
"Network basis of anticonvulsant drug action"
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12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Multiple Ways of Altering Excitability in Epilepsy: What can be targeted? |
7:30 pm - 7:40 pm | Discussion Leader: Manisha Patel (U. of Colorado)
"Introduction"
|
7:40 pm - 8:05 pm | Gary Yellen (Harvard Medical School)
"K(ATP) channels in metabolic control of neuronal excitability"
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8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Dimitri Kullmann (University College London)
"Potassium channel overexpression as a treatment for focal neocortical epilepsy"
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8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Dane Chetkovich (Northwestern U. School of Medicine, Chicago)
"Targeting the trafficking of HCN channels in epilepsy"
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9:15 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Developmental Epilepsies and Co-Morbidities: Are there common mechanisms? |
9:00 am - 9:10 am | Discussion Leader: John Swann (Baylor College of Medicine)
"Introduction" |
9:10 am - 9:35 am | Amy Brooks-Kayal (U. of Colorado and Children's Hospital Colorado)
"Developmental epilepsy syndromes and questions they raise"
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9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Peter Crino (U. of Pennsylvania)
"New etiologies for cortical dysplasias"
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10:10 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Coffee Break |
10:45 am - 10:55 am | Chris Dulla (Tufts University)
"Preventing cortical malformations and hyperexcitability with GABApentin"
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10:55 am - 11:00 am | Discussion |
11:00 am - 11:25 am | Massimo Mantegazza (IPMC, CNRS, Nice-Sophia Antipolis, France)
"Nav 1.1 sodium channel dysfunctions in Dravet syndrome and GEFS+"
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11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Farah Lubin (U. of Alabama, Birmingham)
"Epigenetic mechanisms in epilepsy and epilepsy-related memory dysfunction"
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12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | David Auerbach (U. of Michigan)
"A mouse model of Dravet syndrome reveals alterations in cardiac electrophysiology"
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12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Channel and Transporter Reorganization in the Epileptic Brain:
Do the genetics suggest treatment targets?
|
7:30 pm - 7:40 pm | Discussion Leader: Jaideep Kapur (U. of Virginia)
"Introduction"
|
7:40 pm - 8:05 pm | Samuel Berkovic (U. of Melbourne)
"Glucose transporter mutations in epilepsy"
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8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Robert Macdonald (Vanderbilt University)
"Altered GABAA receptor biogenesis and function in genetic epilepsies" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Jeffrey Noebels (Baylor College of Medicine)
"Ending happily on a negative note: Voltage-gated chloride channels and epilepsy"
|
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |