SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
5:00 pm - 6:00 pm | Welcome Reception (Meet and Relax Before Dinner) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Introductory Comments by GRC Site Staff |
| Welcome by: Jack Parent (Co-Chair), Scott Baraban (Co-Chair), Heinz Beck (Vice-Chair) and Steven Danzer (Vice Chair) |
7:40 pm - 9:30 pm | Keynote Session |
| Discussion Leaders: Jack Parent (Co-Chair) and Scott Baraban (Co-Chair) |
7:50 pm - 8:50 pm | David Prince (Stanford)
"Fifty Years of Epilepsy Research: How Does the Past Inform the Future"
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8:50 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Ion Channel Defects in Intractable Epilepsies |
9:00 am - 9:10 am | Discussion Leader: Miriam Meisler (University of Michigan)
"Introduction" |
9:10 am - 9:35 am | Jennifer Kearney (Northwestern University)
"Ion Channel Defects and Genetic Modifiers"
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9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | William Catterall (University of Washington)
"Selectively Impaired Excitability of Interneurons in a Mouse Model of Dravet Syndrome"
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10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 10:50 am | Brian Grone (University of California, San Francisco)
"Creating and Decoding Zebrafish Models of Genetic Epilepsies"
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10:50 am - 10:55 am | Discussion |
10:55 am - 11:20 am | Edward Cooper (Baylor School of Medicine)
"The KCNQ2-Associated Epilepsy Spectrum: Bedside, Bench, and Back"
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11:20 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Alfonso Represa (Inmed, Inserm, Marseille)
"Neuropathological Basis of Epilepsy in Cortical Development Disorders: Insights from a Rat Model of Doublecortex"
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11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Jacy Wagnon (University of Michigan)
"Mouse Model of a Human SCN8A Epilepsy Mutation"
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12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Bring in the Genes: Identification and Characterization of Epilepsy Mutations |
7:30 pm - 7:40 pm | Discussion Leader: Annapurna Poduri (Boston Children's Hospital, Harvard) "Introduction" |
7:40 pm - 8:05 pm | Heather Mefford (University of Washington)
"Targeted Approaches to Gene Discovery in Epilepsy and Related Disorders"
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8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Diane O'Dowd (University of California, Irvine)
"Modeling SCN1A-Related Seizure Disorders with Drosophila Knock-in Mutants"
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8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | David Goldstein (Duke University)
"Genetic Causes of the Epilepsies: Rare Mutations and Common Pathways?"
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9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Rebecca Boumil (The Jackson Laboratory)
"Pleiotropy in a Dynamin 1 Mouse Model of Epileptic Encephalopathy"
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9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Development and Maldevelopment of the Central Nervous System |
9:00 am - 9:10 am | Discussion Leader: Peter Crino (Temple University) "Introduction" |
9:10 am - 9:35 am | Joseph LoTurco (University of Connecticut)
"Modeling Neuronal Developmental Disruptions by CRISPR-Mediated Genome Editing"
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9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Xinyu Zhao (University of Wisconsin)
"Neural Stem Cells as Model for Studying Autism-Spectrum Disorders"
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10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 10:50 am | Gary Brennan (University of California, Irvine)
"The Transcription Factor NRSF Contributes to Epileptogenesis by Selective Repression of a Subset of Target Genes"
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10:50 am - 10:55 am | Discussion |
10:55 am - 11:20 am | Angelique Bordey (Yale University)
"Epilepsy in Focal Cortical Dysplasia"
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11:20 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Arnold Kriegstein (UCSF)
"New Insights in Development of the Human Cerebral Cortex"
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11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Megan Wyeth (NIH)
"Neto1 Interactions with Kainate Receptors in Somatostatin Interneurons"
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12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Neuronal Microcircuits in Normal and Epileptic Brain |
7:30 pm - 7:40 pm | Discussion Leader: Mark Beenhaker (University of Virginia) "Introduction" |
7:40 pm - 8:05 pm | J. Troy Littleton (MIT)
"Glial Regulation of Neuronal Excitability" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Roger Traub (IBM, Columbia University)
"Gap Junctions, High Frequency Oscillations, and Epilepsy?" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Rosa Cossart (Inserm, Marseille)
"How Inhibition Shapes Interictal Dynamics in Awake Epileptic Mice" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Omar Ahmed (Harvard University)
"Inhibitory Neuronal Control of Human Epilepsy and the Role of Potassium Channels"
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9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Stem Cells to the Rescue |
9:00 am - 9:10 am | Discussion Leader: Jennifer Hsieh (UT Southwestern) "Introduction" |
9:10 am - 9:35 am | Hongjun Song (Johns Hopkins University)
"Studying 15q11.2 Risk Factor by Patient-Derived iPSC and Mouse Models"
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9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Linda Overstreet-Wadiche (University of Alabama at Birmingham)
"Assessing the Function of Adult-Born Hippocampal Neurons"
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10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 10:50 am | Candi LaSarge (Cincinnati Children's Hospital)
"Evidence of Recurrent Network Activation in a PTEN Knockout Model of TLE"
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10:50 am - 10:55 am | Discussion |
10:55 am - 11:20 am | Lori Isom (University of Michigan)
"Role of Sodium Channel SCN1A in Dravet Syndrome and SUDEP"
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11:20 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Vania Broccoli (San Raffaele Scientific Institute, Milan)
"Generation of Functional Forebrain iGABA Interneurons by Direct Genetic Conversion of Skin Fibroblasts"
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11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Sudhir Sivakumaran (Tufts University)
"Erosion of Inhibition and the Development of Pharmacoresistant Status Epilepticus"
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12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Co-Morbidities of Network Dysfunction in Epilepsies and Related Disorders |
7:30 pm - 7:40 pm | Discussion Leader: Amy Brooks-Kayal (University of Colorado, Denver) "Introduction"
|
7:40 pm - 8:00 pm | Timothy Miller (Washington University School of Medicine)
"Antisense Reduction of Tau as a Therapy for Seizures" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Frances Jensen (University of Pennsylvania)
"Altered Synaptic Plasticity Following Seizures Contributes to Cognitive Impairment and Epileptogenesis"
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8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Christophe Bernard (Inserm, Marseille)
"Double Hit Scenario Leading to Reversible Depression and Cognitive Deficits in Epilepsy"
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8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:15 pm | Anne Anderson (Baylor School of Medicine) |
9:15 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Novel Therapeutic Strategies: From Gene Therapy to Drug Interventions |
9:00 am - 9:10 am | Discussion Leader: Avtar Roopra (University of Wisconsin, Madison) "Introduction" |
9:10 am - 9:35 am | Anne Schaefer (Mount Sinai School of Medicine)
"MicroRNA-128, a Novel Regulator of Neuronal Excitability and Motor Behavior in Mice"
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9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Nicholas Poolos (University of Washington)
"c-Jun N-Terminal Kinase (JNK) as an Anti-Epileptic Target"
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10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 10:50 am | Caren Armstrong (University of California, Irvine)
"Optogenetics, Epilepsy, and the 'Dentate Gate'"
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10:50 am - 10:55 am | Discussion |
10:55 am - 11:20 am | Manisha Patel (University of Colorado, Denver)
"Targeting Seizure-Induced Oxidative Stress and Mitochondrial Dysfunction"
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11:20 am - 11:30 am | Discussion |
11:30 am - 11:55 am | David Henshall (Royal College of Surgeons, Ireland)
"MicroRNA Regulation of Neuroinflammation and Epileptogenesis by Targeting Ion Channels"
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11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Laura Ewell (UCSD)
"Pathological High Frequency Oscillations Disrupt Hippocampal Spatial Coding"
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12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Balancing Inhibition and Excitation: Implications for Epileptogenesis |
7:30 pm - 7:40 pm | Discussion Leader: Jaideep Kapur (University of Virginia) "Introduction" |
7:40 pm - 8:05 pm | Carolyn Houser (University of California, Los Angeles)
"Reorganized GABA Circuits in Epilepsy"
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8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Vijayalakshmi Santhakumar (Rutgers University)
"Seizure-Induced Plasticity of Interneuronal Inhibition: Implications for Epileptogenesis"
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8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | John White (University of Utah)
"GCaMPs in New Places -- Shining a Light on Reactive Glia"
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9:15 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |