Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Harnessing Complexity to Better Understand Epilepsies and Improve Their Treatments
Discussion Leaders: Christophe Bernard (UMR 1106, INSERM / Aix-Marseille University, France) and Amy Brooks-Kayal (University of Colorado / Children's Hospital Colorado, USA)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:25 pm
Maxime Guye (Aix Marseille University, France)
"Quantifying Brain Networks in Epilepsy: Is It Clinically Useful?"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
Ivan Soltesz (Stanford University, USA)
"Organization and Control of Hippocampal Circuits in Epilepsy"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Large Scale Networks
Discussion Leader: Akio Ikeda (Kyoto University Graduate School of Medicine, Japan)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Viktor Jirsa (INS, UMR1106 / Aix-Marseille University, France)
"Brain Network Dynamics, Fast and Slow"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
John Terry (University of Exeter, United Kingdom)
"Mathematics of Seizure Genesis and Propagation"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Brian Litt (University of Pennsylvania, USA)
"Network Models to Guide Epilepsy Surgery "
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Dimitri Kullmann (University College London, United Kingdom)
"Cortical Seizure Initiation and Propagation: Insights from Meso-Scale Imaging and Gene Therapy Strategies"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Xiaolong Jiang (Baylor College of Medicine, USA)
"Deciphering Cell Type-Specific Connectivity Abnormalities in Two Animal Models of Absence Epilepsy"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Richard Rosch (University College London, United Kingdom)
"Modelling Epileptogenic Networks from Stereotactic EEG Recordings "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Lori Isom (University of Michigan, USA) and Karen Wilcox (University of Utah, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Behavioral and Cognitive Dysfunction
Discussion Leader: Asla Pitkanen (University of Eastern Finland, Finland)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Kathryn Davis (University of Pennsylvania, USA)
"Interconnections Between Structural, Epileptic and Cognitive Networks"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Edward Boyden (Massachusetts Institute of Technology, USA)
"Tools for Mapping and Repairing Brain Circuits"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Julia Kahn (University of Pennsylvania, USA)
"Circuit-Based Therapies Rescue Cognitive Performance in a Temporal Lobe Epilepsy Mouse Model"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Alexis Lupien-Meilleur (Université de Montréal, Canada)
"Disinhibition of Frontal Cortical Circuits Underlies Inattention and Cognitive Rigidity Associated with Cacna1a Loss-of-Function Mutations"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Astrocytes and Metabolism
Discussion Leader: Tallie Z. Baram (University of California, Irvine, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Amy Brewster (Purdue University, USA)
"Neuropathological Roles for C1q-C3 and Trem2 Phagocytic Signaling in Epilepsy"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Manisha Patel (University of Colorado Anschutz Medical Campus, USA)
"Redox Regulation of Seizure-Induced Neuroinflammation"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Jenny Koenig (Tufts University School of Medicine, USA)
"Glycolytic Inhibition with 2-Deoxyglucose Preserves Inhibitory Cortical Network Function Following Traumatic Brain Injury"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Karen Wilcox (University of Utah, USA)
"mGlur5 Function in Reactive Astrocytes: A Role in High-Frequency Glutamate Uptake During Epileptogenesis"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Christian Steinhaeuser (University of Bonn, Germany)
"Rescue of Glial Gap Junction Coupling Prevents Epileptogenesis"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Emre Yaksi (Kavli Institute for Systems Neuroscience, Norway)
"Studying Neural Circuit Activity and Connectivity During Epilepsy in Zebrafish Brain "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Blood Brain Barrier and Inflammation
Discussion Leader: Aristea Galanopoulou (Albert Einstein College of Medicine, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Shelley Russek (Boston University, USA)
"Identification of a Non-Canonical Role for the JAK/STAT Pathway in the Regulation of Brain Inhibitory Systems"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Alon Friedman (Dalhousie University, Canada)
"Blood-Brain Barrier Dysfunction in Epilepsy: A Translational Approach"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Daniela Kaufer (University of California, Berkeley, USA)
"Vascular Dysfunction as a Common Driver of Neuropathology in the Aged and Injured Brain"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cellular Dysfunction
Discussion Leader: Helen Scharfman (Nathan Kline Institute, New York University, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Omar Ahmed (University of Michigan, USA)
"Uniquely Powerful and Precise High-Frequency Oscillations in a Unique Part of the Limbic System"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Heinz Beck (University of Bonn Medical Center, Germany)
"Altered Input Output Transformation of Hippocampal Neurons in Chronic Epilepsy"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Philippa Karoly (University of Melbourne, Australia)
"Seizure Transitions: A Model-Based Investigation"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Kevin Staley (Harvard Medical School, USA)
"Ictal Neuronal Death"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
Vincent Magloire (University College London, United Kingdom)
"The Dynamic Role of Pv+ Cells in Maintaining Cortical Seizures"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Matt Kelley (Tufts University, USA)
"Reducing KCC2 in the Adult Hippocampus Initiates Epilepsy"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Jean Christophe Poncer (INSERM, France)
"KCC2 Regulates Neuronal Excitability and Rhythmogenesis via Interaction with Task-3 Channels"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genetics/Epigenetics
Discussion Leader: Katja Kobow (Universitätsklinikum Erlangen, Germany)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Jeannie Chin (Baylor College of Medicine, USA)
"Epigenetic Control of Neuronal Function in Neurological Disorders with Recurrent Seizures"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Gemma Carvill (Northwestern University, USA)
"The Role of Chd2 in Chromatin Remodeling and Gene Expression in a Human Neuronal Model of the Genetic Epilepsies"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Ethan Goldberg (The Children's Hospital of Philadelphia, USA)
"De Novo Heterozygous Gain-of-Function Mutations in SCN3A Are a Novel Cause of Early Infantile Epileptic Encephalopathy"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Nadia Khan (University of Wisconsin-Madison, USA)
"Elucidating the Role of Enhancer of Zeste Homolog 2 (EZH2) in Epilepsy"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Stem Cells and iPSCs
Discussion Leader: Jack Parent (University of Michigan, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Kyung-Ok Cho (Catholic University of Korea, South Korea)
"Molecular Regulation of the Dentate Granule Cells for Treating Epilepsy-Associated Cognitive Decline"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Jenny Hsieh (The University of Texas at San Antonio, USA)
"A Critical Period for Aberrant Neurogenesis Rewires Hippocampus Circuitry"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Alex Shcheglovitov (University of Utah, USA)
"Modeling Human Cortical Network Development and Epilepsy with Single Rosette-Derived Cortical Organoids "
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Lori Isom (University of Michigan, USA)
"Discovering Mechanisms of Epileptic Encephalopathy with Sudep"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Steve Danzer (Cincinnati Children's Hospital Medical Center, USA)
"Mechanistic Contributions of Abnormal Hippocampal Granule Cells to Failure of the Dentate Gate"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Betül Uysal (Hertie Institute for Clinical Brain Research, Germany)
"Generation of Human Disease Model for KCNA2-Related Epileptic Encephalopathy Using iPSC-Derived Neurons"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Translational Models
Discussion Leader: Scott Baraban (University of California, San Francisco, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Aliesha Griffin (University of California, San Francisco, USA)
"Novel Zebrafish Epilepsy Models for Translational Drug Discovery"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Burkhard Hoeckendorf (Janelia Research Campus, Howard Hughes Medical Institute, USA)
"Whole-Brain Volumetric Calcium Imaging and Optogenetic Manipulation of Seizures in Zebrafish"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Robert Hunt (University of California, Irvine, USA)
"Chd2 Is Necessary for Neural Circuit Development and Long-Term Memory"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Yu Wang (University of Michigan, USA)
"Multi-Functional Studies of Genes and Pathways in Focal Cortical Dysplasia"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure