Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Complexity in Epilepsy
Discussion Leader: Gemma Carvill (Northwestern University, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:25 pm
Liset Menendez de la Prida (Instituto Cajal, Spanish National Research Council (CSIC), Spain)
"Evaluating the Complex Dynamics of Hippocampal Microcircuits"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
Eve Marder (Brandeis University, United States)
"Cryptic Changes to Degenerate Neurons and Circuits Elicited by Repeated Perturbations of Temperature and High Potassium"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Oscillations, Rhythms and Network Dynamics
Discussion Leaders: Jack Parent (University of Michigan, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:20 am
Zoe Christenson Wick (Icahn School of Medicine at Mount Sinai, United States)
"Closed-Loop Control of Inhibitory Theta Phase Locking and Its Impact on Seizures and Cognition"
9:20 am - 9:25 am
Discussion
9:25 am - 9:50 am
Laura Ewell (University of California - Irvine, United States)
"Spatially Modulated Hippocampal Rhythmic Discharges Impair Working Memory in a Rodent Model of TLE"
9:50 am - 10:00 am
Discussion
10:00 am - 10:25 am
Vikaas Sohal (University of California, San Francisco, United States)
"Long-Range GABAergic Projections from Prefrontal Cortex Regulate Hippocampal Disinhibition and Synchrony"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
Jacob Hull (Stanford University, United States)
"Multi-Regional Oscillation and Spiking Synchronization Coordinates Absence Seizure Generation"
11:15 am - 11:20 am
Discussion
11:20 am - 11:45 am
Christophe Bernard (Inserm, France)
"Rhythms of the Epileptic Brain"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Jennifer Gelinas (Columbia University Irving Medical Center, United States)
"Modulating Pathological Hippocampal-Cortical Dynamics in Temporal Lobe Epilepsy"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Eve Marder (Brandeis University, United States) and Amy Brewster (Southern Methodist University, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Local and Long-Range Circuitry
Discussion Leader: Esther Krook-Magnuson (University of Minnesota, United States)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:20 pm
Martha Streng (University of Minnesota, United States)
"Mesoscale Ca2+ Imaging of Purkinje Cells Reveals Cerebellar Engagement During Chronic, Spontaneous Hippocampal Seizures in a Mouse Model of Temporal Lobe Epilepsy"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:50 pm
Yoav Adam (The Hebrew University of Jerusalem, Israel)
"All-Optical Interrogation of Hippocampal Circuits Using Voltage Imaging"
6:50 pm - 7:05 pm
Discussion
7:05 pm - 7:15 pm
Alexa Tierno (University of California, Irvine, United States)
"Large-Scale 3D Reconstruction of Inhibitory Circuits in an Injured Brain"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
Peyman Golshani (University of California, Los Angeles, United States)
"Unstable Hippocampal Population Codes Underlying Cognitive Deficits in Temporal Lobe Epilepsy"
7:45 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Synaptic and Network Homeostasis
Discussion Leader: Lori Isom (University of Michigan, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:20 am
Sadi Quinones (Tufts University Graduate School of Biomedical Sciences, United States)
"Single Cell RNAseq Analysis of Metabolic Disruption Following Traumatic Brain Injury Suggests a Shift From Identity-Driven to Activity-Driven Metabolic Profiles"
9:20 am - 9:25 am
Discussion
9:25 am - 9:50 am
Seth Grant (University of Edinburgh, United Kingdom)
"How Genetic Disorders Reprogram the Lifespan Synaptome Architecture"
9:50 am - 10:00 am
Discussion
10:00 am - 10:25 am
Aya Takeoka (VIB, Belgium)
"Neurotransmitter Phenotype Switching by Excitatory Spinal Interneurons Regulates Locomotor Recovery after Spinal Cord Injury"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
Quynh Anh Nguyen (Stanford University, United States)
"Microcircuit Alterations Underlie the Emergence of Pathological High Frequency Oscillations"
11:15 am - 11:20 am
Discussion
11:20 am - 11:45 am
Joseph Raimondo (University of Cape Town, South Africa)
"The Dynamics of Chloride Ion Driving Force in the Nervous System"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Konstantin Khodosevich (University of Copenhagen, Denmark)
"Identification of Candidate Neuronal Networks Coordinating Epileptic Activity Using Single Cell Omics"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Glial Signaling and Epileptogenesis
Discussion Leader: Amy Brewster (Southern Methodist University, United States)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:20 pm
Anthony Umpierre (Mayo Clinic, United States)
"Microglial P2Y6 Receptor Calcium Signaling Regulates Microglial Function in Epileptogenesis"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:50 pm
Nicholas Varvel (Emory University School of Medicine, United States)
"Peripheral Immune Cells as a Target in Epilepsy"
6:50 pm - 7:05 pm
Discussion
7:05 pm - 7:15 pm
Juliet Knowles (Stanford University School of Medicine, United States)
"Maladaptive Myelination Promotes Progression of Generalized Epilepsy"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
Maarten Kole (Netherlands Institute for Neuroscience, The Netherlands)
"Myelination, a Critical Player in Inhibitory Neural Circuit Function"
7:45 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Gene Targets and Therapies
Discussion Leader: Dimitri Kullmann (University College London, United Kingdom)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:20 am
Noell Cho (Tufts University, United States)
"Lemur Tyrosine Kinase 3 (LMTK3) Modulates KCC2 Transporter Activity in the Dentate Gyrus via PP1-Dependent Pathway"
9:20 am - 9:25 am
Discussion
9:25 am - 9:50 am
Amy Brooks-Kayal (UC Davis, United States)
"JAK/STAT Regulation of the Transcriptomic Response During Epileptogenesis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:25 am
Mauro Costa-Mattioli (Baylor College of Medicine, United States)
"Dissecting the Role of mTOR Complexes in Epilepsy"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
Marisol Sampedro Castañeda (The Francis Crick Institute, United Kingdom)
"Cav2.3 Phosphorylation in the Pathophysiology of CDKL5 Deficiency Disorder: a New Target for Treatment"
11:15 am - 11:20 am
Discussion
11:20 am - 11:45 am
Stefanie Dedeurwaerdere (UCB BioPharma, Belgium)
"Identifying Gene Networks to Guide Drug Discovery in Structural Epilepsies"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
David Henshall (RCSI University of Medicine & Health Sciences, Ireland)
"MicroRNA Targeting for Acquired and Genetic Epilepsies – Hits, Misses and Complexes"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Non-canonical defects in Inhibitory signaling
Discussion Leader: Ivan Soltesz (Stanford University, United States)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:20 pm
Samantha Hodges (University of Michigan, Department of Pharmacology, United States)
"Mechanisms Regulating Sodium Channel ß1 Subunit Signaling and Transcriptional Modulation in Developmental and Epileptic Encephalopathies"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:50 pm
Elsa Rossignol (CHU Sainte-Justine, Université de Montréal, Canada)
"Interneuron Migration Deficits in Epileptic Encephalopathies"
6:50 pm - 7:05 pm
Discussion
7:05 pm - 7:15 pm
Daniela Miely (Hertie Institute for Clinical Brain Research, University of Tuebingen, Germany)
"Insights Into the Role of Astrocytic EAAT1 in Regulating Glutamate/Chloride Homeostasis and the Development of Neurological Disorders"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
Harald Sontheimer (University of Virginia, United States)
"Perineuronal Nets: Unexpected Contributors to Epilepsy?"
7:45 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Developing Circuits
Discussion Leader: Heinz Beck (University of Bonn Medical Center, Germany)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:20 am
Hannah Happ (Northwestern University, United States)
"Long-read Sequencing and Profiling of RNA-Binding Proteins Reveals the Pathogenic Mechanism of Aberrant Splicing of an SCN1A Poison Exon in Individuals with Epilepsy"
9:20 am - 9:25 am
Discussion
9:25 am - 9:50 am
Arnold Kriegstein (UCSF, United States)
"Molecular Insights into Human Brain Development and the Origin of Cortical Interneurons"
9:50 am - 10:00 am
Discussion
10:00 am - 10:25 am
Annapurna Poduri (Boston Children's Hospital/Harvard Medical School, United States)
"Mosaic Mutations, Malformations, mTOR, and More: the Role of Post-Zygotic Mutation in Developmental Epilepsies"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
Sattar Khoshkhoo (Harvard Medical School, United States)
"Somatic Mutations Activating MAPK Signaling in Mesial Temporal Lobe Epilepsy"
11:15 am - 11:20 am
Discussion
11:20 am - 11:45 am
Stéphanie Baulac (Paris Brain Institute (ICM), France)
"Brain Mosaicism in mTOR-related Cortical Malformation: Toward Novel Therapeutics Targets"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Gaia Colasante (Ospedale San Raffaele, Italy)
"Temporal Manipulation of Scn1a Gene Expression in Dravet Syndrome"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Epigenetic and Metabolic Targets in Epileptic Brain
Discussion Leader: Jeannie Chin (Baylor College of Medicine, United States)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:20 pm
Soad Elziny (University of Maryland School of Medicine, United States)
"Effects of Slc35a2 Knockout on Golgi Structure and Cortical Lamination"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:50 pm
Farah Lubin (University of Alabama at Birmingham (UAB), United States)
"Role of DNA Hydroxymethylation in the Cellular and Molecular Response to Epilepsy"
6:50 pm - 7:05 pm
Discussion
7:05 pm - 7:15 pm
Chia-Hsuan Fu (Baylor College of Medicine, United States)
"Role of sFRP3 in Seizure-Induced Dysregulation of Neurogenesis"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
Katja Kobow (Universitätsklinikum Erlangen, Germany)
"Epigenetic Disease Classification in Focal Epilepsies"
7:45 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure