| Saturday |
| 1:30 pm - 4:30 pm | Arrival and Check-in |
| 3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:15 pm - 4:00 pm | Keynote Session: Translational Research in Epilepsy |
| Discussion Leader: Ivan Soltesz (Stanford University, USA) |
| 3:15 pm - 3:50 pm | Daniel Lowenstein (University of California, San Francisco, USA)
"The Coin of the Realm" |
| 3:50 pm - 4:00 pm | Discussion |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Neural Circuits and Networks in the Epilepsies |
| Discussion Leader: John Huguenard (Stanford University, USA) |
| 5:30 pm - 5:45 pm | Stefanie Makinson (Gladstone Institutes, University of California, San Francisco, USA)
"Optogenetic Targeting of the Thalamus for Bidirectional Control of Seizures in Dravet Syndrome" |
| 5:45 pm - 5:55 pm | Discussion |
| 5:55 pm - 6:10 pm | Jacob Hull (University of Michigan, USA)
"Pyramidal Neuron Subpopulation Specific Increase in Excitability with Reduced Function and Expression of Voltage Gated Sodium Channels in the Scn1b Null Mouse Model of Dravet Syndrome" |
| 6:10 pm - 6:20 pm | Discussion |
| 6:20 pm - 6:35 pm | Bethany Hosford (Cincinnati Children's Hospital Medical Center, USA)
"Ablation of Adult-Generated, Ectopic Dentate Granule Cells Can Decrease Seizure Severity" |
| 6:35 pm - 6:45 pm | Discussion |
| 6:45 pm - 7:00 pm | Xi Du (University of Michigan, USA)
"Retrograde Trans-Synaptic Tracing Reveals Novel as Well as Altered Presynaptic Inputs onto Adult-Born Dentate Granule Cells in Experimental Temporal Lobe Epilepsy" |
| 7:00 pm - 7:10 pm | Discussion |
| 7:10 pm - 7:25 pm | Anthony Umpierre (University of Utah, USA)
"Alterations in Astrocyte Calcium Activity and Signaling Pathways During Epileptogenesis" |
| 7:25 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Regulation and Control of Excitability |
| Discussion Leader: Lori Isom (University of Michigan, USA) |
| 9:00 am - 9:15 am | Hannah Alfonsa (University of Oxford, United Kingdom)
"Cl-Out: A Novel Cooperative Optogenetic Tool for Extruding Chloride from Neurons" |
| 9:15 am - 9:25 am | Discussion |
| 9:25 am - 9:40 am | Matthew Kelley (Tufts University, USA)
"Deficits in Neuronal Chloride Transport Tune Seizure Susceptibility and Severity" |
| 9:40 am - 9:50 am | Discussion |
| 9:50 am - 10:05 am | Giordano Lippi (University of California, San Diego, USA)
"MicroRNA-101 Constrains the Development of Neural Networks to Balance Excitation" |
| 10:05 am - 10:15 am | Discussion |
| 10:15 am - 10:30 am | Lauren Lau (Tufts University, USA)
"Targeting a2d-1 Prevents Pathological Synaptogenesis, Cell Death and Epileptogenic Circuit Reorganization Following Neonatal Cortical Insult" |
| 10:30 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | Angel Lopez (Baylor College of Medicine, USA)
"Ankyrin-G Isoform Imbalance and Interneuronopathy Link Epilepsy and Bipolar Disorder" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Mentorship Component: Careers and Funding in Epilepsy Research |
| Discussion Leaders: Omar Ahmed (University of Michigan, USA) and Laura Ewell (University of California, San Diego, USA) |
| 1:30 pm - 2:30 pm | Panel Discussion |
| "Careers and Funding in Epilepsy Research" |
|
- Daniel Lowenstein (University of California, San Francisco, USA)
- Julie Milder (Citizens United for Research in Epilepsy (CURE), USA)
- Vicky Whittemore (National Institute of Neurological Disorders and Stroke, NIH, USA)
- Manisha Patel (University of Colorado Anschutz Medical Campus, USA)
- Amy Brooks-Kayal (Children's Hospital Colorado, USA)
|
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
