| Sunday, June 20th |
| 7:30pm - 9:30pm |
Multidrug Resistance in Eukaryotes & Prokaryotes |
|
Jack Kaplan, Discussion Leader
- Welcoming Comments, etc.
Jack Kaplan
- "The Two Nucleotide Binding Sites of P-glycoprotein"
Ina Urbatsch (University of Rochester)
- "Genetic Studies Suggest That an Electrostatic Interaction is Essential for Multidrug Recognition by a Multidrug Transporter"
Eitan Bibi (Weizmann Institute)
- "Structural Basis of Multi-drug Recognition by BmrR"
Dick Brennan (Oregon Health Sciences University)
- General Discussion
|
| Monday, June 21st |
| 9:00am - 12:30pm |
Approaches to Membrane Protein Structure |
|
Stephen White, Discussion Leader
- "Electron Crystallography of 2D Crystals"
Werner Kühlbrandt (MPI, Frankfurt)
- "What to do While Awaiting Crystals of a Membrane Transport Protein and Thereafter"
H. Ronald Kaback (UCLA)
- "Studying Structure and Movement Through Site-Directed Labeling"
David Farrens (Oregon Health Sciences University)
- "Three-dimensional Structure of NhaA, a Bacterial Ion-coupled Transporter at 7 Å Resolution"
Karen Williams (MPI, Frankfurt)
Poster Session I
(4:30pm - 6:00pm)
|
| 7:30pm - 10:30pm |
Transmembrane Helix Stability and Movements |
|
Rhoda Blostein, Discussion Leader
- "Translocation of the Colicin 1a Channel-forming Domain Goes On and On..."
Karen Jakes (Albert Einstein College of Medicine)
- "Topological Reorientation During Aquaporin-1 Maturation in the Endoplassmic Reticulum"
Bill Skach (Oregon Health Sciences University)
- "Stabilization of the M5M6 Transmembrane Hairpin by K+ Ions in P2-type ATPases"
Jake Kaplan (Oregon Health Services University)
- "Energetics of Protein Folding into Membranes"
Stephen White (UCI)
- General Discussion
|
| Tuesday, June 22nd |
| 9:00am - 12:15pm |
Channel Structure and Function |
|
Don Hilgemann, Discussion Leader
- "The Moving Parts of Voltage-gated K+ Channels'
Gary Yellen(Harvard)
- "Novel Chemical Strategies for Studying the Relationship Between Ligand Binding and Channel Opening in Cyclic Nucleotide-gated Channels"
Jeff Karpen (University of Colorado)
- "Tethered blockers as structural probes of the Shaker potassium channel"
Rob Blaustein (Brandeis University)
- "Structure Involved in Activation of Calcium Channels"
Kurt Beam (Colorado State University)
- General Discussion
Poster Session I
(4:30pm - 6:00pm)
|
| 7:30pm - 10:15pm |
Structure Function Correlation in Transporters |
|
Carolyn Slayman, Discussion Leader
- "Co-transport through conformational changes"
Ernie Wright (UCLA)
- "Aquaporins, Blueprints for Cellular Plumbing Systems"
Peter Agre (Johns Hopkins University)
- "Structure, Function, and Folding of ABC Transporters
Phil Thomas (University of Texas Southwestern)
- "Determinants for Sodium- and Potassium-coupled Glutamate Transport Function in a Region of Unusual Topography"
Baruch Kanner (Hebrew University of Jerusalem)
- General Discussion
|
| Wednesday, June 23rd |
| 9:00am - 12:15pm |
Pumps |
|
Kazuya Taniguchi, Discussion Leader
- "Na, K-ATPase: Amino Acids Important for Cation Binding and Reactivity of Transmembrane Cysteines Probed with Hg2+"
Jose Arguello (Worcester Polytechnic)
- "Consequences of Mutations and Chimeric Replacements in the Na, K- and Gastric H, K-ATPases"
Rhoda Blostein (McGill University)
- "Specific Inhibitor Binding to Mutants of a P2-type ATPase"
Keith Munson (West LA Veterans Hospital)
- "Multidrug Resistance Systems in Lactococcus lactis"
Wil Konings (University of Groningen)
- General Discussion
Poster Session II
(4:30pm - 6:00pm)
|
| 7:30pm - 10:15pm |
Novel Methods for Transporter Protein Characterization |
|
Biff Forbush, Discussion Leader
- "Transporter Protein Kinetics Probed by Presteady State Methods"
Ernest Bamberg (MPI, Frankfurt)
- "Structure/function analysis of an ABC transporter using random epitope-tagged mutants"
Beth Traxler (University of Washington)
- "Differential Function of Alpha 1 and Alpha 2 Isoforms of the Na,K-ATPase as Determined by Gene Targeting"
Jerry B. Lingrel (University of Cincinnatti)
- "The Voltage Sensor Studied with Extrinsic Fluorescence and Histidine Mutagenesis"
Pancho Bezanilla (UCLA)
- General Discussion
|
| Thursday, June 24th |
| 9:00am - 12:15pm |
Regulation of Membrane Transporters |
|
Ernie Wright, Discussion Leader
- "Modulation of the Na-K-Cl Cotransporter (NKCC1) by an Unknown Kinase and by Bound Protein Phosphatase-1"
Biff Forbush (Yale University)
- "Regulation of Plant H+ and Ca2+-ATPases"
Michael Palmgren (Copenhagen University)
- "Regulation of Ion Transport by Phosphatidylinositides"
Don Hilgemann (UTSW, Dallas)
- "Osmosensing by H+-Osmoprotectant Symporter ProP of Escherichia coli"
Janet Wood, University of Guelph
- General Discussion
Poster Session II
(4:30pm - 6:00pm)
- Business Meeting (7:30pm - 8:00pm)
|
| 8:00pm - 10:00pm |
Membrane Protein Synthesis and Insertion |
|
Jake Kaplan, Discussion Leader
- "The translocon: A very large and dynamic pore in the ER membrane"
Art Johnson (Texas A & M)
- General Discussion
|
