| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Principles of Membrane Protein Construction |
| Ernie Wright, Discussion Leader |
| Biff Forbush
Welcome |
| Don Engleman
Membrane Protein Insights From Computational Biology |
| Steven Smith
The Nature and Distribution of Helix Interactions in Membrane Proteins |
| 9:30 pm | Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am | Group Photo |
| 9:00 am - 12:30 pm | Aquaporins |
| Robert Stroud, Discussion Leader |
| Bing Jap
Structure and Functional Mechanism of Water Channels |
| Peter Agre
Aquaporin water channels--Atomic structures and clinical defects |
| Emad Tajkhorshid
Computational studies of aquaporin function and mechanism |
| Christophe Maurel
Aquaporins: molecular mechanisms of transmembrane water transport in plants |
| David Savage
The structure of AqpZ |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Ion Channels |
| Dick Horn, Discussion Leader |
| Declan Doyle
The crystal structure of the KirBac1.1 potassium channel in the closed state |
| Tzyh-Chang Hwang
Probing the CFTR channel pore with blockers |
| Francis Valiyaveetil
Lipids and the KcsA potassium channel |
| Raimond Dutzler
Structural basis for ion conduction and gating in ClC chloride channels |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ABC transporters |
| Peter Maloney, Discussion Leader |
| Kaspar Locher
Structural and mechanistic studies of the E. coli vitamin B12 importer BtuCD |
| Amy Davidson
Maltose transport in E. coli |
| Phil Thomas
Mechanochemistry of the ABC Transporter Reaction Cycle |
| Edward Yu
AcrB: Structural Basis for Multidrug Binding |
| Sriram Subramaniam
Three-dimensional structure of the
oxalate transporter at 6.5 Å resolution |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Major Facilitators |
| Sriram Subramaniam, Discussion Leader |
| Peter Maloney
Biology and biophysics of OxlT, a model membrane transporter |
| Ron Kaback
Structure and function of lac permease |
| Shimon Schuldinger
Coupling of H++ and Substrate Fluxes in a Multidrug Transporter |
| Da-Neng Wang
Structure and Mechanism of the Glycerol-3-phosphate Transporter from E. coli |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Regulation of transporters |
| John Orlowski, Discussion Leader |
| Sergio Grinstein
Regulation of the distribution and activity of the Na/H exhanger |
| Heini Murer
The renal type IIa Na-Pi-cotransporter: function, structure and regulation |
| Rhoda Blostein
Regulation of Na,K-ATPase |
| David Clapham
Converting a transporter to a channel: A spontaneous mutation in DMT1 confers a gain of function |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Water movement in transporters |
| Chris Miller & Fred Sigworth, Co-discussion leaders |
| Ernie Wright
Revisiting the role of cotransporters in water transport across membranes |
| Jean-Yves LaPointe
Specific roles of Na+ and glucose in generating early osmotic gradients driving water through SGLT1 |
| Mechanism of K-channel gating |
| Chris Miller & Fred Sigworth, Co-discussion leaders |
| Rod MacKinnon
Structure of a voltage-gated potassium channel |
| Dick Horn
Testing Structural Models of Gating: Hinges & Paddles |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | P-type ATPases |
| Rhoda Blostein, Discussion Leader |
| Barry Rosen
Mechanism of an arsenite-translocating ATPase |
| Jose Arguello
Thermophilic Heavy Metal Transport ATPases: Structural Determinants of Metal Selectivity |
| Svetlana Lutsenko
Molecular Mechanisms of Copper Transport in Human Cells |
| Pablo Artigas
Turning the Na/K pump into a dual-gated cation channel with palytoxin |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Late Breaking News |
| Ron Kaback, Discussion Leader |
| Michael Wiener
Substrate binding and transmembrane signaling in the outer membrane cobalamin transporter BtuB |
| Janos Lanyi
Transport mechanism from crystal structures of seven of the nine states in the bacteriorhodopsin photocycle |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
